{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T12:09:11Z","timestamp":1789560551047,"version":"build-2803163510"},"reference-count":66,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,2,4]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n                  <jats:p>Human papillomavirus (HPV) vaccination has been shown to reduce the HPV-related cervical cancer burden. The aim for the present study was to investigate the factors associated with the uptake of HPV vaccination among adolescent girls aged 13\u201318 years seeking health services at a health center in Uganda. This cross-sectional study was conducted at Naguru Teenage Information and Health Center, an adolescent clinic of Kiswa Health Center III in Kampala, Uganda. Information was obtained from 134 adolescent girls aged 13\u201318 years who were seeking services at the center. Bivariate and multivariable analyses were conducted to identify factors associated with HPV vaccine uptake. The uptake of a single dose of the HPV vaccine was 18.7% (25\/134). Factors associated with HPV vaccine uptake included being from an ethnic group such as the Acholi\/Lango (adjusted prevalence ratio [aPR] = 0.3; 95% CI: 0.09\u20130.6), being from an ethnic group such as Basoga (aPR = 0.2; 95% CI: 0.08\u20130.8), parents\u2019 level of knowledge (aPR = 0.3; 95% CI: 0.1\u20130.8), perception of HPV vaccine benefits (aPR = 0.3; 95% CI: 0.1\u20130.9), knowledge of the location of the nearest HPV vaccination site (aPR = 0.3; 95% CI: 0.1\u20130.8), distance to the healthcare facility (aPR = 0.5; 95% CI: 0.2\u20130.7), and healthcare worker recommendations (aPR = 0.3; 95% CI: 0.1\u20130.7). The uptake of the HPV vaccine was low. There is a need to conduct awareness campaigns for parents, adolescents, and the community about the benefits of the HPV vaccine. This will increase HPV vaccine uptake and reduce the burden of cervical cancer in the community.<\/jats:p>","DOI":"10.4269\/ajtmh.25-0503","type":"journal-article","created":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T18:57:21Z","timestamp":1764874641000},"page":"355-359","source":"Crossref","is-referenced-by-count":1,"title":["Factors Associated with Human Papillomavirus Vaccination Uptake Among Adolescent Girls in Uganda"],"prefix":"10.4269","volume":"114","author":[{"given":"Stanley","family":"Ggingo","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Makerere University College of Health Sciences, Kampala, Uganda;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Obore","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Mulago Specialized Women and Neonatal Hospital, Kampala, Uganda;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miton","family":"Musaba","sequence":"additional","affiliation":[{"name":"Faculty of Health Science, Department of Obstetrics and Gynaecology, Busitema University, Mbale, Uganda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julius","family":"Wandabwa","sequence":"additional","affiliation":[{"name":"Faculty of Health Science, Department of Obstetrics and Gynaecology, Busitema University, Mbale, Uganda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Kiondo","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Makerere University College of Health Sciences, Kampala, Uganda;"},{"name":"Department of Obstetrics and Gynaecology, Mulago Specialized Women and Neonatal Hospital, Kampala, Uganda;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"b1","series-title":"Clin Microbiol Rev","first-page":"1","article-title":"Human papillomavirus and cervical cancer","volume":"16","author":"Burd","year":"2003"},{"key":"b2","article-title":"Human Papillomaviru and Cervical Cancer.","year":"2020"},{"key":"b3","series-title":"BMC Public Health","first-page":"142","article-title":"Integrated cervical cancer screening in Mayuge District Uganda (ASPIRE Mayuge): A pragmatic sequential cluster randomized trial protocol","volume":"20","author":"Nakisige","year":"2020"},{"key":"b4","series-title":"BMC Womens Health","first-page":"145","article-title":"Factors associated with HPV vaccination uptake in Uganda: A multi-level analysis","volume":"20","author":"Isabirye","year":"2020"},{"key":"b5","series-title":"Vaccine","first-page":"3918","article-title":"Declines in HPV vaccine type prevalence in women screened for cervical cancer in the United States: Evidence of direct and herd effects of vaccination","volume":"37","author":"Markowitz","year":"2019"},{"key":"b6","series-title":"BMC Public Health","first-page":"171","article-title":"Health system factors influencing uptake of Human Papilloma Virus (HPV) vaccine among adolescent girls 9\u201315 years in Mbale District, Uganda","volume":"20","author":"Nabirye","year":"2020"},{"key":"b7","article-title":"Global Strategy to Accelerate the Elimination of Cervical Cancer as a Public Health Problem.","year":"2020"},{"key":"b8","series-title":"Lancet Glob Health","first-page":"e453","article-title":"Global estimates of human papillomavirus vaccination coverage by region and income level: A pooled analysis","volume":"4","author":"Bruni","year":"2016"},{"key":"b9","series-title":"Health Policy Plan","first-page":"701","article-title":"Health systems constraints and facilitators of human papillomavirus immunization programmes in sub-Saharan Africa: A systematic review","volume":"35","author":"Amponsah-Dacosta","year":"2020"},{"key":"b10","article-title":"Global Vaccine Uptake and Projected Cervical Cancer Disease Reductions.","author":"Bruni","year":"2016"},{"key":"b11","series-title":"PLoS One","first-page":"e0253735","article-title":"Why don\u2019t adolescent girls in a rural Uganda district initiate or complete routine 2-dose HPV vaccine series: Perspectives of adolescent girls, their caregivers, healthcare workers, community health workers and teachers","volume":"16","author":"Rujumba","year":"2021"},{"key":"b12","series-title":"Pan Afr Med J","first-page":"184","article-title":"Level and factors associated with uptake of Human papillomavirus infection vaccine among female adolescents in Lira District, Uganda","volume":"31","author":"Esther","year":"2018"},{"key":"b13","series-title":"Student\u2019s J Health Res Africa","first-page":"20","article-title":"Factors affecting uptake of human papilloma virus (HPV) vaccination among in-school adolescent girls in Wakiso District, Central Uganda","volume":"1","author":"Nanyunja","year":"2020"},{"key":"b14","article-title":"Uptake of Human Papilloma Vaccination in Uganda, Barriers and Opportunities: A Policy Brief.","author":"Kamulegeya","year":"2020"},{"key":"b15","series-title":"BMC Womens Health","first-page":"362","article-title":"Factors associated with uptake of human papilloma virus vaccine among school girls aged 9\u201314 years in Lira City northern Uganda: A cross-sectional study","volume":"23","author":"Nakayita","year":"2023"},{"key":"b16","series-title":"Afr Health Sci","first-page":"45","article-title":"Awareness and uptake of human papilloma virus vaccines among female secondary school students in Benin City, Nigeria","volume":"20","author":"Ezeanochie","year":"2020"},{"key":"b17","series-title":"J Family Med Prim Care","first-page":"3627","article-title":"Knowledge, attitude and uptake of human papillomavirus vaccination among female undergraduates in Lagos State, Nigeria","volume":"8","author":"Oluwole","year":"2019"},{"key":"b18","series-title":"Front Oncol","first-page":"1380663","article-title":"A guide to global access to HPV vaccination to all women in low- and middle-income countries; a minireview of innovation and equity","volume":"14","author":"Ewongwo","year":"2024"},{"key":"b19","series-title":"BMC Public Health","first-page":"1848","article-title":"Determinants of HPV-vaccination uptake and subgroups with a lower uptake in the Netherlands","volume":"21","author":"de Munter","year":"2021"},{"key":"b20","series-title":"Vaccine","first-page":"4038","article-title":"No association between HPV vaccination and infertility in U.S. females 18\u201333 years old","volume":"38","author":"Schmuhl","year":"2020"},{"key":"b21","series-title":"PLoS One","first-page":"e0309597","article-title":"Religious beliefs and practices toward HPV vaccine acceptance in Islamic countries: A scoping review","volume":"19","author":"Kisa","year":"2024"},{"key":"b22","series-title":"BMC Womens Health","first-page":"109","article-title":"Individual-level and community-level determinants of cervical cancer screening among Kenyanwomen: A multilevel analysis of a Nationwide survey","volume":"17","author":"Tiruneh","year":"2017"},{"key":"b23","first-page":"220","article-title":"A longitudinal study on determinants of HPV vaccination uptake in parents\/guardians from different ethnic backgrounds in Amsterdam, the Netherlands","volume":"17","author":"Alberts","year":"2017"},{"key":"b24","series-title":"BMC Public Health","first-page":"1836","article-title":"Improvement of parent\u2019s awareness, knowledge, perception, and acceptability of human papillomavirus vaccination after a structured-educational intervention","volume":"20","author":"Sitaresmi","year":"2020"},{"key":"b25","series-title":"PLoS One","first-page":"e0193054","article-title":"Parents\u2019 knowledge, beliefs, and 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setting","volume":"18","author":"Mabeya","year":"2018"},{"key":"b29","series-title":"Eur J Midwifery","first-page":"2","article-title":"Knowledge, attitudes and perceptions of Nigerian parents towards human papilloma virus (HPV) vaccines","volume":"4","author":"Ohareri","year":"2020"},{"key":"b30","series-title":"Adolesc Health Med Ther","first-page":"87","article-title":"Factors associated with the human papillomavirus vaccine coverage in Gulu District, Uganda","volume":"14","author":"Odongo Ojok","year":"2023"},{"key":"b31","series-title":"Vaccine","first-page":"1187","article-title":"Provider communication and HPV vaccination: The impact of recommendation quality","volume":"34","author":"Gilkey","year":"2016"},{"key":"b32","series-title":"JAMA Pediatr","first-page":"76","article-title":"Barriers to human papillomavirus vaccination among US adolescents: A systematic review of the literature","volume":"168","author":"Holman","year":"2014"},{"key":"b33","series-title":"Vaccines (Basel)","first-page":"1515","article-title":"Healthcare provider recommendations and observed changes in HPV vaccination acceptance during the COVID-19 pandemic","volume":"10","author":"Osaghae","year":"2022"},{"key":"b1","series-title":"Clin Microbiol Rev","first-page":"1","article-title":"Human papillomavirus and cervical cancer","volume":"16","author":"Burd","year":"2003"},{"key":"b2","article-title":"Human Papillomaviru and Cervical Cancer.","year":"2020"},{"key":"b3","series-title":"BMC Public Health","first-page":"142","article-title":"Integrated cervical cancer screening in Mayuge District Uganda (ASPIRE Mayuge): A pragmatic sequential cluster randomized trial protocol","volume":"20","author":"Nakisige","year":"2020"},{"key":"b4","series-title":"BMC Womens Health","first-page":"145","article-title":"Factors associated with HPV vaccination uptake in Uganda: A multi-level analysis","volume":"20","author":"Isabirye","year":"2020"},{"key":"b5","series-title":"Vaccine","first-page":"3918","article-title":"Declines in HPV vaccine type prevalence in women screened for cervical cancer in the United States: Evidence of direct and herd effects of vaccination","volume":"37","author":"Markowitz","year":"2019"},{"key":"b6","series-title":"BMC Public Health","first-page":"171","article-title":"Health system factors influencing uptake of Human Papilloma Virus (HPV) vaccine among adolescent girls 9\u201315 years in Mbale District, Uganda","volume":"20","author":"Nabirye","year":"2020"},{"key":"b7","article-title":"Global Strategy to Accelerate the Elimination of Cervical Cancer as a Public Health Problem.","year":"2020"},{"key":"b8","series-title":"Lancet Glob Health","first-page":"e453","article-title":"Global estimates of human papillomavirus vaccination coverage by region and income level: A pooled 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adolescents in Lira District, Uganda","volume":"31","author":"Esther","year":"2018"},{"key":"b13","series-title":"Student\u2019s J Health Res Africa","first-page":"20","article-title":"Factors affecting uptake of human papilloma virus (HPV) vaccination among in-school adolescent girls in Wakiso District, Central Uganda","volume":"1","author":"Nanyunja","year":"2020"},{"key":"b14","article-title":"Uptake of Human Papilloma Vaccination in Uganda, Barriers and Opportunities: A Policy Brief.","author":"Kamulegeya","year":"2020"},{"key":"b15","series-title":"BMC Womens Health","first-page":"362","article-title":"Factors associated with uptake of human papilloma virus vaccine among school girls aged 9\u201314 years in Lira City northern Uganda: A cross-sectional study","volume":"23","author":"Nakayita","year":"2023"},{"key":"b16","series-title":"Afr Health Sci","first-page":"45","article-title":"Awareness and uptake of human papilloma virus vaccines among female secondary school students in 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