{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T16:17:43Z","timestamp":1778084263424,"version":"3.51.4"},"reference-count":46,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"5","license":[{"start":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T00:00:00Z","timestamp":1778025600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5,6]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n                  <jats:p>\n                    Cutaneous leishmaniasis is an endemic parasitic infection in Colombia that typically presents as ulcerated skin lesions, although atypical variants can mimic diverse dermatosis leading to misdiagnosis and delayed treatment. We report the case of a 32-year-old woman with a 15-year history of progressive granulomatous and exophytic tumor-like plaques involving her lower face and neck. She was initially misdiagnosed with lymphocutaneous sporotrichosis and treated unsuccessfully with itraconazole for 1 year. The chronic facial involvement during her formative years resulted in major aesthetic and psychosocial consequences. Histopathology and direct smear ultimately confirmed\n                    <jats:italic>Leishmania<\/jats:italic>\n                    spp. infection. She received intramuscular meglumine antimoniate with marked clinical improvement. This case illustrates the diagnostic challenges of atypical chronic cutaneous leishmaniasis and emphasizes the need for thorough evaluation in endemic regions. Early recognition and appropriate management are essential to avoid therapeutic delays and long-term psychosocial impact.\n                  <\/jats:p>","DOI":"10.4269\/ajtmh.25-0575","type":"journal-article","created":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T15:32:52Z","timestamp":1773934372000},"page":"865-869","source":"Crossref","is-referenced-by-count":0,"title":["Fifteen-Year Evolution of Chronic Cutaneous Leishmaniasis Mimicking Other Dermatoses"],"prefix":"10.4269","volume":"114","author":[{"given":"Luisa","family":"Hurtado-Rossi","sequence":"first","affiliation":[{"name":"Centro Internacional de Entrenamiento e Investigaciones M\u00e9dicas (CIDEIM), Cali, Colombia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa","family":"Gutierrez-Gomez","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Dermatology Section, Universidad del Valle, Cali, Colombia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alvaro J.","family":"Martinez-Valencia","sequence":"additional","affiliation":[{"name":"Centro Internacional de Entrenamiento e Investigaciones M\u00e9dicas (CIDEIM), Cali, Colombia;"},{"name":"Universidad Icesi, Cali, Colombia;"},{"name":"Fundaci\u00f3n Valle del Lili, Cali, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonny A.","family":"Garc\u00eda-Luna","sequence":"additional","affiliation":[{"name":"Centro Internacional de Entrenamiento e Investigaciones M\u00e9dicas (CIDEIM), Cali, Colombia;"},{"name":"Universidad Icesi, Cali, Colombia;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2795","reference":[{"key":"b1","article-title":"Leishmaniasis.","year":"2023"},{"key":"b2","series-title":"Trans R Soc Trop Med Hyg","first-page":"560","article-title":"Spatial epidemiology of cutaneous leishmaniasis in Colombia: Socioeconomic and demographic factors associated with a growing epidemic","volume":"113","author":"Hern\u00e1ndez","year":"2019"},{"key":"b3","series-title":"Clin Dermatol","first-page":"140","article-title":"Cutaneous leishmaniasis: A great imitator","volume":"38","author":"Gurel","year":"2020"},{"key":"b4","series-title":"Am J Clin Dermatol","first-page":"823","article-title":"Cutaneous leishmaniasis: A 2022 updated narrative review into diagnosis and management developments","volume":"23","author":"de Vries","year":"2022"},{"key":"b5","article-title":"Cutaneous and Mucosal Leishmaniasis.","year":"2007"},{"key":"b6","series-title":"Clin Dermatol","first-page":"203","article-title":"Cutaneous leishmaniasis","volume":"25","author":"Bailey","year":"2007"},{"key":"b7","series-title":"Lancet","first-page":"951","article-title":"Leishmaniasis","volume":"392","author":"Burza","year":"2018"},{"key":"b8","series-title":"Rev Asoc Colomb Dermatol Cir Dermatol","first-page":"138","article-title":"Leishmaniasis cut\u00e1nea cr\u00f3nica en el nuevo mundo: Serie de casos de otra gran simuladora","volume":"30","author":"Gallo","year":"2022"},{"key":"b9","series-title":"Actas Dermosifiliogr (Engl Ed.)","first-page":"601","article-title":"Cutaneous and mucocutaneous leishmaniasis","volume":"112","author":"Abad\u00edas-Granado","year":"2021"},{"key":"b10","series-title":"Indian Dermatol Online J","first-page":"507","article-title":"Giant chronic cutaneous leishmaniasis: Case report of an unusual presentation","volume":"8","author":"Patel","year":"2017"},{"key":"b11","series-title":"Pathogens","first-page":"890","article-title":"The extraordinary case of a woman with a 30-year-long diffuse leishmaniasis cured with one single ampoule of intranasal pentavalent antimoniate","volume":"12","author":"Gon\u00e7alves","year":"2023"},{"key":"b12","series-title":"BMC Infect Dis","first-page":"597","article-title":"A case of imported Leishmania infantum cutaneous leishmaniasis: An unusual presentation occurring 19 years after travel","volume":"14","author":"Crowe","year":"2014"},{"key":"b13","series-title":"Infect Immun","first-page":"2872","article-title":"Chronicity of dermal leishmaniasis caused by Leishmania panamensis is associated with parasite-mediated induction of chemokine gene expression","volume":"82","author":"Navas","year":"2014"},{"key":"b14","article-title":"Atlas Interactivo de Leishmaniasis en Las Am\u00e9ricas: Aspectos Cl\u00ednicos y Diagn\u00f3sticos Diferenciales.","year":"2020"},{"key":"b15","series-title":"Acta Med Iran","first-page":"274","article-title":"Cutaneous leishmaniasis with unusual clinical and histological presentation: Report of four cases","volume":"51","author":"Moravvej","year":"2013"},{"key":"b16","series-title":"Rom J Morphol Embryol","first-page":"51","article-title":"Messy granuloma: An additional pattern of granulomatous reaction","volume":"57","author":"Fernandez-Flores","year":"2016"},{"key":"b17","series-title":"Am J Trop Med Hyg","first-page":"645","article-title":"Characterization of the histopathologic features in patients in the early and late phases of cutaneous leishmaniasis","volume":"96","author":"Saldanha","year":"2017"},{"key":"b18","series-title":"Arch Dermatol","first-page":"198","article-title":"Chronic lupoid leishmaniasis: Evaluation by polymerase chain reaction","volume":"132","author":"Momeni","year":"1996"},{"key":"b19","series-title":"J Am Acad Dermatol","first-page":"911","article-title":"Cutaneous and mucocutaneous leishmaniasis: Differential diagnosis, diagnosis, histopathology, and management","volume":"73","author":"Handler","year":"2015"},{"key":"b20","series-title":"Indian J Dermatol Venereol Leprol","first-page":"294","article-title":"Histopathological spectrum in cutaneous leishmaniasis: A study in Oman","volume":"67","author":"Venkataram","year":"2001"},{"key":"b21","series-title":"Am J Trop Med Hyg","first-page":"489","article-title":"Social and economic burden of human leishmaniasis","volume":"94","author":"Okwor","year":"2016"},{"key":"b22","series-title":"J Antimicrob Chemother","first-page":"3599","article-title":"Global access to antifungal therapy and its variable cost","volume":"71","author":"Kneale","year":"2016"},{"key":"b23","series-title":"Drugs","first-page":"833","article-title":"Adverse effects associated with long-term administration of azole antifungal agents","volume":"79","author":"Ben\u00edtez","year":"2019"},{"key":"b1","article-title":"Leishmaniasis.","year":"2023"},{"key":"b2","series-title":"Trans R Soc Trop Med Hyg","first-page":"560","article-title":"Spatial epidemiology of cutaneous leishmaniasis in Colombia: Socioeconomic and demographic factors associated with a growing epidemic","volume":"113","author":"Hern\u00e1ndez","year":"2019"},{"key":"b3","series-title":"Clin Dermatol","first-page":"140","article-title":"Cutaneous leishmaniasis: A great 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