{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T21:32:42Z","timestamp":1775079162755,"version":"3.50.1"},"reference-count":38,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"4","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,4,1]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n                  <jats:p>\n                    Mother-to-child transmission of\n                    <jats:italic>Trypanosoma cruzi<\/jats:italic>\n                    , the parasitic cause of Chagas disease, occurs in 5\u201310% of affected pregnancies. Congenital infection is usually asymptomatic, so if maternal infection is not suspected, the affected newborn may go undetected. As detection and antiparasitic treatment in early life result in much higher cure rates than treatment later in life, it is important to explore opportunities for catch-up testing of children born to women found to have\n                    <jats:italic>T. cruzi<\/jats:italic>\n                    infection. We piloted a multidisciplinary adult\u2013pediatric disease referral pathway and developed a clinic to screen children of women diagnosed with Chagas disease. We evaluated the impact, acceptability, and patient experience of the pathway, including exploration of barriers to accessing prior testing. Of the 28 referred children, 23 (82%) attended the clinic, 22 (79%) were tested, and 1 child was diagnosed with congenital infection. The service was deemed effective and beneficial by both healthcare professionals and parents.\n                  <\/jats:p>","DOI":"10.4269\/ajtmh.25-0656","type":"journal-article","created":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T18:41:25Z","timestamp":1772131285000},"page":"716-719","source":"Crossref","is-referenced-by-count":0,"title":["Catch-Up Screening to Improve Detection of Congenital Chagas Disease in a Nonendemic Setting"],"prefix":"10.4269","volume":"114","author":[{"given":"Anna","family":"Bot\u00e9-Casamitjana","sequence":"first","affiliation":[{"name":"Hospital for Tropical Diseases, University College London Hospitals NHS Trust, London, United Kingdom;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanna","family":"Martin","sequence":"additional","affiliation":[{"name":"Children and Young People\u2019s Division, University College London Hospitals NHS Foundation Trust, London, United Kingdom;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jackie","family":"Touray","sequence":"additional","affiliation":[{"name":"Children and Young People\u2019s Division, University College London Hospitals NHS Foundation Trust, London, United Kingdom;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalie","family":"Elkheir","sequence":"additional","affiliation":[{"name":"Hospital for Tropical Diseases, University College London Hospitals NHS Trust, London, United Kingdom;"},{"name":"Clinical Research Department, London School of Hygiene and Tropical Medicine, London, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura Eve","family":"Nabarro","sequence":"additional","affiliation":[{"name":"Hospital for Tropical Diseases, University College London Hospitals NHS Trust, London, United Kingdom;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Eisen","sequence":"additional","affiliation":[{"name":"Hospital for Tropical Diseases, University College London Hospitals NHS Trust, London, United Kingdom;"},{"name":"Children and Young People\u2019s Division, University College London Hospitals NHS Foundation Trust, London, United Kingdom;"},{"name":"Clinical Research Department, London School of Hygiene and Tropical Medicine, London, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David A. J","family":"Moore","sequence":"additional","affiliation":[{"name":"Hospital for Tropical Diseases, University College London Hospitals NHS Trust, London, United Kingdom;"},{"name":"Clinical Research Department, London School of Hygiene and Tropical Medicine, London, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2795","reference":[{"key":"b1","series-title":"Lancet","first-page":"1388","article-title":"Chagas disease","volume":"375","author":"Rassi","year":"2010"},{"key":"b2","series-title":"PLoS Negl Trop Dis","first-page":"e0007694","article-title":"Congenital Chagas disease: Updated recommendations for prevention, diagnosis, treatment, and follow-up of newborns and siblings, girls, women of childbearing age, and pregnant women","volume":"13","author":"Carlier","year":"2019"},{"key":"b3","series-title":"Acta Trop","first-page":"22","article-title":"Chagas disease in Spain, the United States and other non-endemic countries","volume":"115","author":"Gascon","year":"2010"},{"key":"b4","series-title":"Res Rep Trop Med","first-page":"25","article-title":"Diagnosis and clinical management of Chagas disease: An increasing challenge in non-endemic areas","volume":"13","author":"Su\u00e1rez","year":"2022"},{"key":"b5","series-title":"American Trypanosomiasis Chagas Disease","first-page":"517","author":"Carlier","year":"2017"},{"key":"b6","series-title":"Euro Surveill","first-page":"1900011","article-title":"Epidemiology of congenital Chagas disease 6 years after implementation of a public health surveillance system, Catalonia, 2010 to 2015","volume":"24","author":"Basile","year":"2019"},{"key":"b7","series-title":"Eurosurveillance","first-page":"19972","article-title":"The current screening programme for congenital transmission of Chagas disease in Catalonia, Spain","volume":"16","author":"Basile","year":"2011"},{"key":"b8","series-title":"Lancet Glob Health","first-page":"e439","article-title":"Cost-effectiveness of Chagas disease screening in Latin American migrants at primary health-care centres in Europe: A Markov model analysis","volume":"5","author":"Requena-M\u00e9ndez","year":"2017"},{"key":"b9","series-title":"Open Forum Infect Dis","first-page":"S431","article-title":"773. Screening for Chagas disease in East Boston, Massachusetts from 2017\u20132020 reveals 0.9% prevalence","volume":"7","author":"Manne-Goehler","year":"2020"},{"key":"b10","article-title":"Chagas disease: Migrant Health Guide. Advice and Guidance on the Health Needs of Migrant Patients for Healthcare Practitioners.","year":"2014"},{"key":"b11","series-title":"Travel Med Infect Dis","first-page":"101760","article-title":"Chagas disease in the United Kingdom: A review of cases at the Hospital for Tropical Diseases London 1995\u20132018. The current state of detection of Chagas disease in the UK","volume":"36","author":"Gonz\u00e1lez Sanz","year":"2020"},{"key":"b12","series-title":"Emerg Infect Dis","first-page":"1313","article-title":"Updated estimates and mapping for prevalence of Chagas disease among adults, United States","volume":"28","author":"Irish","year":"2022"},{"key":"b13","article-title":"No Longer Invisible: The Latin American community in London.","author":"McIlwaine","year":"2011"},{"key":"b14","series-title":"J Infect Dis","first-page":"1601","article-title":"Recommendations for screening and diagnosis of Chagas disease in the United States","volume":"225","author":"Forsyth","year":"2022"},{"key":"b15","series-title":"Rev Inst Med Trop Sao Paulo","first-page":"227","article-title":"Fluorescent antibody test for the serodiagnosis of American trypanosomiasis. Technical modification employing preserved culture forms of Trypanosoma cruzi in a slide test","volume":"8","author":"Camargo","year":"1966"},{"key":"b16","series-title":"PLoS Negl Trop Dis","first-page":"e0009954","article-title":"Roadblocks in Chagas disease care in endemic and nonendemic countries: Argentina, Colombia, Spain, and the United States. The NET-Heart project","volume":"15","author":"Miranda-Arboleda","year":"2021"},{"key":"b17","series-title":"PLoS Negl Trop Dis","first-page":"e0007447","article-title":"Proposed multidimensional framework for understanding Chagas disease healthcare barriers in the United States","volume":"13","author":"Forsyth","year":"2019"},{"key":"b18","series-title":"BMC Public Health","first-page":"332","article-title":"Diagnostic pathways of Chagas disease in Spain: A qualitative study","volume":"23","author":"Iglesias-Rus","year":"2023"},{"key":"b19","series-title":"BMJ Public Health","first-page":"e002940","article-title":"Community-based serological screening for Chagas disease in London: A cross-sectional, observational pilot study","volume":"3","author":"Elkheir","year":"2025"},{"key":"b1","series-title":"Lancet","first-page":"1388","article-title":"Chagas disease","volume":"375","author":"Rassi","year":"2010"},{"key":"b2","series-title":"PLoS Negl Trop Dis","first-page":"e0007694","article-title":"Congenital Chagas disease: Updated recommendations for prevention, diagnosis, treatment, and follow-up of newborns and siblings, girls, women of childbearing age, and pregnant women","volume":"13","author":"Carlier","year":"2019"},{"key":"b3","series-title":"Acta Trop","first-page":"22","article-title":"Chagas disease in Spain, the United States and other non-endemic countries","volume":"115","author":"Gascon","year":"2010"},{"key":"b4","series-title":"Res Rep Trop Med","first-page":"25","article-title":"Diagnosis and clinical management of Chagas disease: An increasing challenge in non-endemic areas","volume":"13","author":"Su\u00e1rez","year":"2022"},{"key":"b5","series-title":"American Trypanosomiasis Chagas Disease","first-page":"517","author":"Carlier","year":"2017"},{"key":"b6","series-title":"Euro Surveill","first-page":"1900011","article-title":"Epidemiology of congenital Chagas disease 6 years after implementation of a public health surveillance system, Catalonia, 2010 to 2015","volume":"24","author":"Basile","year":"2019"},{"key":"b7","series-title":"Eurosurveillance","first-page":"19972","article-title":"The current screening programme for congenital transmission of Chagas disease in Catalonia, Spain","volume":"16","author":"Basile","year":"2011"},{"key":"b8","series-title":"Lancet Glob Health","first-page":"e439","article-title":"Cost-effectiveness of Chagas disease screening in Latin American migrants at primary health-care centres in Europe: A Markov model analysis","volume":"5","author":"Requena-M\u00e9ndez","year":"2017"},{"key":"b9","series-title":"Open Forum Infect Dis","first-page":"S431","article-title":"773. Screening for Chagas disease in East Boston, Massachusetts from 2017\u20132020 reveals 0.9% prevalence","volume":"7","author":"Manne-Goehler","year":"2020"},{"key":"b10","article-title":"Chagas disease: Migrant Health Guide. Advice and Guidance on the Health Needs of Migrant Patients for Healthcare Practitioners.","year":"2014"},{"key":"b11","series-title":"Travel Med Infect Dis","first-page":"101760","article-title":"Chagas disease in the United Kingdom: A review of cases at the Hospital for Tropical Diseases London 1995\u20132018. The current state of detection of Chagas disease in the UK","volume":"36","author":"Gonz\u00e1lez Sanz","year":"2020"},{"key":"b12","series-title":"Emerg Infect Dis","first-page":"1313","article-title":"Updated estimates and mapping for prevalence of Chagas disease among adults, United States","volume":"28","author":"Irish","year":"2022"},{"key":"b13","article-title":"No Longer Invisible: The Latin American community in London.","author":"McIlwaine","year":"2011"},{"key":"b14","series-title":"J Infect Dis","first-page":"1601","article-title":"Recommendations for screening and diagnosis of Chagas disease in the United States","volume":"225","author":"Forsyth","year":"2022"},{"key":"b15","series-title":"Rev Inst Med Trop Sao Paulo","first-page":"227","article-title":"Fluorescent antibody test for the serodiagnosis of American trypanosomiasis. Technical modification employing preserved culture forms of Trypanosoma cruzi in a slide test","volume":"8","author":"Camargo","year":"1966"},{"key":"b16","series-title":"PLoS Negl Trop Dis","first-page":"e0009954","article-title":"Roadblocks in Chagas disease care in endemic and nonendemic countries: Argentina, Colombia, Spain, and the United States. The NET-Heart project","volume":"15","author":"Miranda-Arboleda","year":"2021"},{"key":"b17","series-title":"PLoS Negl Trop Dis","first-page":"e0007447","article-title":"Proposed multidimensional framework for understanding Chagas disease healthcare barriers in the United States","volume":"13","author":"Forsyth","year":"2019"},{"key":"b18","series-title":"BMC Public Health","first-page":"332","article-title":"Diagnostic pathways of Chagas disease in Spain: A qualitative study","volume":"23","author":"Iglesias-Rus","year":"2023"},{"key":"b19","series-title":"BMJ Public Health","first-page":"e002940","article-title":"Community-based serological screening for Chagas disease in London: A cross-sectional, observational pilot study","volume":"3","author":"Elkheir","year":"2025"}],"container-title":["The American Journal of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/114\/4\/article-p716.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/114\/4\/article-p716.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/114\/4\/article-p716.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T19:21:40Z","timestamp":1775071300000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/114\/4\/article-p716.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,1]]},"references-count":38,"journal-issue":{"issue":"4"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.25-0656","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"value":"0002-9637","type":"print"},{"value":"1476-1645","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,1]]}}}