{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T14:58:12Z","timestamp":1791385092361,"version":"4.3.3"},"reference-count":25,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,7]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n                  <jats:p>\n                    Evolving genomic diversity of\n                    <jats:italic>Mycobacterium tuberculosis<\/jats:italic>\n                    complex pathogens is poorly known in French Polynesia, a remote archipelago in the southern Pacific Ocean. A total of 321 mycobacteria sampled from 321 patients presenting pulmonary tuberculosis between 1998 and 2010 at the microbiology laboratory of the French Polynesia Hospital Centre in Tahiti were whole genome sequenced (WGS), disclosing three major\n                    <jats:italic>M. tuberculosis sensu stricto<\/jats:italic>\n                    sublineages: L4.4.1.1 S-type, L4.1.1.3 X-Type, and L4.1.2.1 Haarlem. Furthermore, 20 isolates were identified as nontuberculous mycobacteria, including\n                    <jats:italic>Mycobacterium fortuitum<\/jats:italic>\n                    , which accounted for 65% of the identified nontuberculous mycobacteria, as well as\n                    <jats:italic>Mycobacterium paragordonae<\/jats:italic>\n                    and\n                    <jats:italic>Mycobacterium gordonae<\/jats:italic>\n                    identified with\n                    <jats:italic>M. tuberculosis<\/jats:italic>\n                    in two samples. Two further isolates were potentially representative of novel species in the\n                    <jats:italic>Mycobacterium<\/jats:italic>\n                    and\n                    <jats:italic>Actinomadura<\/jats:italic>\n                    genera. In total, 43 isolates exhibited in silico predicted antibiotic resistance to first- and second-line antibiotics. Combined with previously published data, the data reported here indicate a 12-year trend of decreasing diversity among the\n                    <jats:italic>M. tuberculosis<\/jats:italic>\n                    population circulating in Tahiti and the seemingly unsuccessful implantation of a recently imported of East African-Indian sublineage (L1.2.1.2.1). These findings contrast with the long-term persistence and predominance of the X-type family with L4.1.1.3; the S-type family with L4.4.1.1 and L4.4.2; the Haarlem family with L4.1.2 and L4.1.2.1, and the LAM family with L4.3.3, L4.3.2, and L4.3.4.2. These observations suggest that in remote territories such as the French Polynesia archipelago\n                    <jats:italic>M. tuberculosis<\/jats:italic>\n                    may rapidly adapt to local ecosystems.\n                  <\/jats:p>","DOI":"10.4269\/ajtmh.25-0681","type":"journal-article","created":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T16:08:43Z","timestamp":1785427723000},"page":"745-750","source":"Crossref","is-referenced-by-count":0,"title":["Genomic Diversity of Mycobacterium tuberculosis Complex in Tahiti, French Polynesia"],"prefix":"10.4269","volume":"115","author":[{"given":"Jos\u00e9phine K.","family":"Badiane","sequence":"first","affiliation":[{"name":"MEPHI, Aix-Marseille University, Marseille, France;"},{"name":"IHU M\u00e9diterran\u00e9e Infection, Marseille, France;"},{"name":"Institut de Recherche en Sant\u00e9, de Surveillance \u00c9pid\u00e9miologique et de Formations (IRESSEF), Dakar, S\u00e9n\u00e9gal;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Levy","sequence":"additional","affiliation":[{"name":"Centre Hospitalier de Polyn\u00e9sie Fran\u00e7aise, Papeete, French Polynesia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mamadou","family":"Beye","sequence":"additional","affiliation":[{"name":"Assistance Publique-H\u00f4pitaux de Marseille, Marseille, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Robinne","sequence":"additional","affiliation":[{"name":"Assistance Publique-H\u00f4pitaux de Marseille, Marseille, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mamadou","family":"Ndao","sequence":"additional","affiliation":[{"name":"Institut de Recherche en Sant\u00e9, de Surveillance \u00c9pid\u00e9miologique et de Formations (IRESSEF), Dakar, S\u00e9n\u00e9gal;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastien","family":"Cortaredona","sequence":"additional","affiliation":[{"name":"IHU M\u00e9diterran\u00e9e Infection, Marseille, France;"},{"name":"Aix-Marseille Universit\u00e9, IRD, SSA, MINES, Marseille, France;"},{"name":"Aix Marseille Universit\u00e9, SSA, RITMES, Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghiles","family":"Grine","sequence":"additional","affiliation":[{"name":"MEPHI, Aix-Marseille University, Marseille, France;"},{"name":"IHU M\u00e9diterran\u00e9e Infection, Marseille, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Drancourt","sequence":"additional","affiliation":[{"name":"MEPHI, Aix-Marseille University, Marseille, France;"},{"name":"IHU M\u00e9diterran\u00e9e Infection, Marseille, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"issue":"1","key":"b1","series-title":"Publ Soc Fr Hist Outre-Mers","first-page":"121","article-title":"Tahiti et ses \u00eeles: 1880\u20131914. 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