{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T13:20:44Z","timestamp":1788355244073,"version":"build-2803163510"},"reference-count":41,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,2]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n                  <jats:p>\n                    Vitamin D affects immune function and possibly, dengue severity, but evidence is inconsistent. Observational studies comparing vitamin D levels between severe and nonsevere dengue were systematically searched. A random-effects meta-analysis was conducted. Heterogeneity was quantified using\n                    <jats:italic>I<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    . Subgroup and sensitivity analyses were performed. Six studies with 1,130 participants were included. The pooled odds ratio (OR) for severe dengue with vitamin D deficiency was 1.77 (95% CI: 0.75\u20134.16,\n                    <jats:italic>P<\/jats:italic>\n                    = 0.194) with substantial heterogeneity (\n                    <jats:italic>I<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    = 61.6%). A subgroup analysis showed a significant association in children (OR: 51.20, 95% CI: 3.12\u2013842.95). Excluding an outlier yielded a significant fixed-effect OR of 1.67 (95% CI: 1.04\u20132.67,\n                    <jats:italic>P<\/jats:italic>\n                    = 0.034) with reduced heterogeneity (\n                    <jats:italic>I<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    = 46.1%). Vitamin D deficiency might be linked to higher odds of severe dengue, especially in children, but confirmation requires larger sample sizes. Establishing causality and assessing vitamin D supplementation in high-risk groups require prospective studies.\n                  <\/jats:p>","DOI":"10.4269\/ajtmh.26-0139","type":"journal-article","created":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T16:23:28Z","timestamp":1783009408000},"page":"424-429","source":"Crossref","is-referenced-by-count":0,"title":["Vitamin D Deficiency and Severe Dengue Fever: A Systematic Review and Meta-Analysis"],"prefix":"10.4269","volume":"115","author":[{"given":"Chuchun","family":"Zhuang","sequence":"first","affiliation":[{"name":"School of Basic Medicine and Public Health, Jinan University, Guangzhou, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinxiaodi","family":"Yan","sequence":"additional","affiliation":[{"name":"School of Basic Medicine and Public Health, Jinan University, Guangzhou, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufeng","family":"Liang","sequence":"additional","affiliation":[{"name":"Southern China Center for Disease Control and Prevention, Guangzhou, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihua","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Public Health, Guangzhou Medical University, Guangzhou, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lian","family":"Cai","sequence":"additional","affiliation":[{"name":"School of Public Health, Guangzhou Medical University, Guangzhou, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukun","family":"Lin","sequence":"additional","affiliation":[{"name":"School of Public Health, Guangzhou Medical University, Guangzhou, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaowen","family":"Feng","sequence":"additional","affiliation":[{"name":"School of Public Health, Southern Medical University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huacheng","family":"Yan","sequence":"additional","affiliation":[{"name":"Southern China Center for Disease Control and Prevention, Guangzhou, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"issue":"4","key":"b1","series-title":"Clin Microbiol Rev","first-page":"e00244-24","article-title":"Dengue and severe dengue","volume":"38","author":"Kalimuddin","year":"2025"},{"issue":"5","key":"b2","series-title":"Semin Immunopathol","first-page":"563","article-title":"Immune-mediated cytokine storm and its role in severe dengue","volume":"39","author":"Srikiatkhachorn","year":"2017"},{"issue":"10","key":"b3","series-title":"Pathogens","first-page":"1179","article-title":"The role of growth factors in the pathogenesis of dengue: A scoping review","volume":"11","author":"Fiestas 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