{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T17:21:55Z","timestamp":1788283315515,"version":"build-2803163510"},"reference-count":46,"publisher":"American Society of Tropical Medicine and Hygiene","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,1]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n                  <jats:p>\n                    Invasive aspergillosis typically occurs in immunocompromised hosts but has been increasingly recognized following viral illnesses, including dengue and coronavirus disease 2019. Herein, a fatal case of disseminated aspergillosis following severe dengue is described, and the association is systematically reviewed. A previously healthy 25-year-old woman presented with fever and multiorgan dysfunction. Dengue IgM results were positive, and other tropical infections were excluded. Despite intensive care, the patient developed progressive respiratory failure, refractory shock, and acute kidney injury and died. An autopsy revealed diffuse alveolar damage and extensive invasive aspergillosis involving the bronchi, pulmonary vasculature, and myocardium. In the present systematic review, 21 additional cases of invasive aspergillosis following dengue (total\n                    <jats:italic>n<\/jats:italic>\n                    = 22; median age 36 years, 59% male) were identified, predominantly in Asia. Fifteen cases (68%) had pulmonary involvement. Most patients had severe dengue with multiorgan dysfunction. The overall mortality was 63.6%; 23% of cases were diagnosed postmortem. Invasive aspergillosis complicating severe dengue broadens the spectrum of viral-associated aspergillosis.\n                  <\/jats:p>","DOI":"10.4269\/ajtmh.26-0140","type":"journal-article","created":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T17:09:51Z","timestamp":1788282591000},"source":"Crossref","is-referenced-by-count":0,"title":["Invasive Aspergillosis Following Dengue: An Autopsy Case and Review of the Literature"],"prefix":"10.4269","author":[{"given":"Avichal","family":"Rajpal","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Immanuvel","family":"Jebaraj","sequence":"additional","affiliation":[{"name":"Department of Histopathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inderpaul Singh","family":"Sehgal","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kritarth","family":"Rathi","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sangamitra","family":"Rajasekaran","sequence":"additional","affiliation":[{"name":"Department of Histopathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uma","family":"Nahar","sequence":"additional","affiliation":[{"name":"Department of Histopathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuruswamy Thurai","family":"Prasad","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shivaprakash M.","family":"Rudramurthy","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, Postgraduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ritesh","family":"Agarwal","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valliappan","family":"Muthu","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"issue":"7","key":"b1","series-title":"Pediatr Blood Cancer","first-page":"1249","article-title":"Dengue fever in patients with pediatric malignancy on chemotherapy: A concern in tropical countries","volume":"57","author":"Bahl","year":"2011"},{"issue":"1","key":"b2","series-title":"BMC Pharmacol Toxicol","first-page":"8","article-title":"A case report of intravenous posaconazole in hepatic and renal impairment patient with invasive Aspergillus terreus infection: Safety and role of therapeutic drug monitoring","volume":"18","author":"Dilokpattanamongkol","year":"2017"},{"key":"b3","series-title":"Enferm Infecc Microbiol","first-page":"125","article-title":"Invasive pulmonary aspergillosis in non neutropenic patient","volume":"33","author":"Juliana","year":"2013"},{"issue":"4","key":"b4","series-title":"Pediatr Crit Care Med","first-page":"389","article-title":"Invasive nosocomial aspergillosis associated with heart failure and complete heart block following recovery from dengue shock syndrome","volume":"8","author":"Kohli","year":"2007"},{"issue":"5","key":"b5","series-title":"Southeast Asian J Trop Med Public Health","first-page":"1106","article-title":"Infection-associated hemophagocytic syndrome among patients with dengue shock syndrome and invasive aspergillosis: A case series and review of the literature","volume":"42","author":"Larbcharoensub","year":"2011"},{"issue":"12","key":"b6","series-title":"J Infect Public Health","first-page":"1893","article-title":"Aspergillus coinfection in critically Ill patients with severe dengue","volume":"16","author":"Lin","year":"2023"},{"key":"b7","series-title":"Indian J Crit Care Med","first-page":"323","article-title":"Invasive pulmonary aspergillosis in an immunocompetent patient with severe dengue fever","volume":"18","author":"Nasa","year":"2014"},{"key":"b8","series-title":"JCDR","first-page":"OR01","article-title":"Dengue co-infections-An emerging entity during the outbreak","volume":"12","author":"Panda","year":"2018"},{"issue":"1","key":"b9","series-title":"J Clin Sci Res","first-page":"35","article-title":"Invasive pulmonary Aspergillus infection in an immunocompetent host following severe dengue","volume":"8","author":"Reddy","year":"2019"},{"issue":"4","key":"b10","series-title":"Curr Med Mycol","first-page":"32","article-title":"Aspergillus fumigatus cerebral abscess following hemodialysis: A case report","volume":"8","author":"Sagar","year":"2022"},{"key":"b11","series-title":"Indian J Otolaryngol Head Neck Surg","first-page":"3321","article-title":"Invasive fungal infections in dengue recovered patients: A new phenomenon in the Covid-19 era","volume":"74","author":"Singhal","year":"2022"},{"key":"b12","series-title":"Indian J Pub Health Res 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