{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T15:48:57Z","timestamp":1791906537848,"version":"4.3.4"},"reference-count":14,"publisher":"American Society of Tropical Medicine and Hygiene","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,13]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n                  <jats:p>\n                    A case of an immunocompetent male patient in his 50s, an oil field worker from the northeastern part of India who presented with fever, weight loss over 4 months, and multiple umbilicated papulonodular lesions on his face and nodular lesions over the hard palate, is reported. The initial suspicion was talaromycosis, which is endemic in that part of the country. Periodic acid-Schiff and Grocott-Gomori\u2019s methenamine silver staining of the skin biopsy specimen from the forehead revealed numerous yeast-like bodies morphologically resembling Histoplasma within the histiocytes. A culture of the skin biopsy grew\n                    <jats:italic>Histoplasma capsulatum<\/jats:italic>\n                    . The patient received liposomal amphotericin B (3 mg\/kg\/day) but later was shifted to oral itraconazole because of acute kidney injury. The patient exhibited improvement, with flattening of skin lesions and no development of new lesions during treatment. This case highlights histoplasmosis mimicking talaromycosis and the importance of tissue diagnosis for accurate identification.\n                  <\/jats:p>","DOI":"10.4269\/ajtmh.26-0160","type":"journal-article","created":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T15:20:44Z","timestamp":1791904844000},"source":"Crossref","is-referenced-by-count":0,"title":["Disseminated Histoplasmosis Presenting as Mucocutaneous Lesions in an Immunocompetent Patient"],"prefix":"10.4269","author":[{"given":"Prudhvi Krishna","family":"Nukala","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases, Institute of Post Graduate Medical Education and Research, Kolkata, India;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayan","family":"Basu","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Institute of Post Graduate Medical Education and Research, Kolkata, India;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yogiraj","family":"Ray","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Institute of Post Graduate Medical Education and Research, Kolkata, India;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kokila","family":"Banerjee","sequence":"additional","affiliation":[{"name":"Tribedi and Roy Diagnostic Laboratory, Kolkata, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"b1","series-title":"Einstein (Sao Paulo)","first-page":"eRC5488","article-title":"Primary cutaneous histoplasmosis difficult to treat in immunocompetent patient: Case report and literature review","volume":"19","author":"Batista","year":"2021"},{"issue":"7","key":"b2","series-title":"Med Mycol","first-page":"774","article-title":"Disseminated histoplasmosis in an apparently immunocompetent individual from north India: A case report and review","volume":"51","author":"Kathuria","year":"2013"},{"issue":"6","key":"b3","series-title":"Dermatology","first-page":"934","article-title":"Cutaneous histoplasmosis in HIV seronegative patients: A clinicopathological analysis","volume":"237","author":"Ahuja","year":"2021"},{"issue":"4","key":"b4","series-title":"J Infect","first-page":"268","article-title":"Disseminated Penicillium marneffei infection among HIV-infected patients in Manipur State, India","volume":"45","author":"Ranjana","year":"2002"},{"issue":"4","key":"b5","series-title":"Indian J Dermatol Venereol Leprol","first-page":"465","article-title":"Primary cutaneous histoplasmosis in an immunocompetent patient presenting with severe pruritus","volume":"84","author":"Patra","year":"2018"},{"issue":"6","key":"b6","series-title":"Indian J Dermatol","first-page":"552","article-title":"Disseminated histoplasmosis with oral and cutaneous manifestations in an immunocompetent patient","volume":"65","author":"Sen","year":"2020"},{"issue":"1","key":"b7","series-title":"Infection","first-page":"169","article-title":"Analysis of clinical characteristics and prognosis of talaromycosis (with or without human immunodeficiency virus) from a non-endemic area: A retrospective study","volume":"50","author":"Shen","year":"2022"},{"key":"b8","series-title":"JAAD Case Rep","first-page":"97","article-title":"Generalized cutaneous talaromycosis (Penicilliosis) in an immunocompetent individual","volume":"50","author":"Aryanian","year":"2024"},{"issue":"6","key":"b9","series-title":"Am J Trop Med Hyg","first-page":"1749","article-title":"Case report: Histoplasmosis in Himachal Pradesh (India): An emerging endemic focus","volume":"97","author":"Mahajan","year":"2017"},{"issue":"6","key":"b10","series-title":"Am J Trop Med Hyg","first-page":"982","article-title":"Histoplasma capsulatum: More widespread than previously thought","volume":"90","author":"Antinori","year":"2014"},{"issue":"5","key":"b11","series-title":"J Pathol Transl Med","first-page":"482","article-title":"Acid-fastness of histoplasma in surgical pathology practice","volume":"51","author":"Rajeshwari","year":"2017"},{"issue":"6","key":"b12","series-title":"J Fungi","first-page":"647","article-title":"An overview of diagnostic and management strategies for talaromycosis, an underrated disease","volume":"9","author":"Zaongo","year":"2023"},{"issue":"6","key":"b13","series-title":"J Clin Microbiol","first-page":"1612","article-title":"Laboratory diagnostics for histoplasmosis","volume":"55","author":"Azar","year":"2017"},{"issue":"7","key":"b14","series-title":"Clin Infect Dis","first-page":"807","article-title":"Clinical practice guidelines for the management of patients with histoplasmosis: 2007 update by the Infectious Diseases Society of America","volume":"45","author":"Wheat","year":"2007"}],"container-title":["The American Journal of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/aop\/article-10.4269-ajtmh.26-0160\/article-10.4269-ajtmh.26-0160.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/aop\/article-10.4269-ajtmh.26-0160\/article-10.4269-ajtmh.26-0160.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T15:20:44Z","timestamp":1791904844000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/aop\/article-10.4269-ajtmh.26-0160\/article-10.4269-ajtmh.26-0160.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,13]]},"references-count":14,"URL":"https:\/\/doi.org\/10.4269\/ajtmh.26-0160","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"value":"0002-9637","type":"print"},{"value":"1476-1645","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,13]]}}}