{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T13:47:11Z","timestamp":1785937631596,"version":"3.56.0"},"reference-count":6,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,5]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n                  <jats:p>\n                    Cutaneous tuberculosis is an uncommon manifestation of\n                    <jats:italic>Mycobacterium tuberculosis<\/jats:italic>\n                    infection and may present diverse and atypical clinical features, often resulting in diagnostic delay. The case of a 72-year-old woman who presented with a gradually progressive nodular swelling on the left side of her nose, associated with epiphora, is reported in the present study. A clinical examination revealed a firm rhino-facial nodular lesion with ipsilateral nasolacrimal duct obstruction. Initial investigations were inconclusive, and the Mantoux test result was negative. Repeat histopathology revealed epithelioid granulomas with multinucleated giant cells consistent with granulomatous dermatitis. A cutaneous tuberculosis-specific assay result was positive, in conjunction with clinicopathological findings, which supported the diagnosis of an atypical nodular type of lupus vulgaris. The patient showed marked clinical improvement after the initiation of standard antitubercular therapy. This case highlights the diagnostic challenges posed by atypical facial lupus vulgaris and underscores the importance of clinicopathological correlation, with adjunctive use of immunological assays when conventional investigations are inconclusive, particularly in tuberculosis-endemic regions.\n                  <\/jats:p>","DOI":"10.4269\/ajtmh.26-0177","type":"journal-article","created":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T15:34:18Z","timestamp":1781019258000},"page":"242-244","source":"Crossref","is-referenced-by-count":0,"title":["Cutaneous Tuberculosis Presenting as Rhino-Facial Nodular Swelling"],"prefix":"10.4269","volume":"115","author":[{"given":"Deepti","family":"Singh","sequence":"first","affiliation":[{"name":"Department of Dermatology and STD, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arun","family":"Somasundaram","sequence":"additional","affiliation":[{"name":"Department of Dermatology and STD, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karthik","family":"Lakshmi Narayanan","sequence":"additional","affiliation":[{"name":"Department of Dermatology and STD, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheetanshu","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Dermatology and STD, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malathi","family":"Munisamy","sequence":"additional","affiliation":[{"name":"Department of Dermatology and STD, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gurumurthy","family":"Balasubramanian","sequence":"additional","affiliation":[{"name":"Department of Radiodiagnosis, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjay","family":"Sriram","sequence":"additional","affiliation":[{"name":"Department of Pathology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"b1","series-title":"Jugan Geongang Gwa Jilbyeong","first-page":"55","article-title":"Review of the global burden of tuberculosis in 2023: Insights from the WHO Global Tuberculosis Report 2024","volume":"18","author":"Lee","year":"2025"},{"issue":"9","key":"b2","series-title":"Oxf Med Case Reports","first-page":"omaf154","article-title":"Lupus vulgaris with a pseudo tumoral presentation, case report","volume":"2025","author":"El Ali","year":"2025"},{"issue":"4","key":"b3","series-title":"Indian J Dermatol Venereol Leprol","first-page":"562","article-title":"Lupus vulgaris masquerading as tumorous growth","volume":"87","author":"Sirka","year":"2021"},{"issue":"6","key":"b4","series-title":"Microorganisms","first-page":"1151","article-title":"The presence of esat-6 and cfp10 and other gene orthologs of the RD 1 region in non-tuberculous mycobacteria, mycolicibacteria, mycobacteroides and mycolicibacter as possible impediments for the diagnosis of (animal) tuberculosis","volume":"12","author":"Gcebe","year":"2024"},{"issue":"4","key":"b5","series-title":"Lancet Respir Med","first-page":"259","article-title":"Safety and efficacy of the C-Tb skin test to diagnose Mycobacterium tuberculosis infection, compared with an interferon \u03b3 release assay and the tuberculin skin test: A phase 3, double-blind, randomised, controlled trial","volume":"5","author":"Ruhwald","year":"2017"},{"issue":"4","key":"b6","series-title":"Clin Infect Dis","first-page":"668","article-title":"Sensitivity, specificity, and safety of a novel ESAT6-CFP10 skin test for tuberculosis infection in China: 2 randomized, self-controlled, parallel-group phase 2b trials","volume":"74","author":"Xu","year":"2022"}],"container-title":["The American Journal of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/115\/2\/article-p242.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/115\/2\/article-p242.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/115\/2\/article-p242.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T13:10:41Z","timestamp":1785935441000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/115\/2\/article-p242.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,5]]},"references-count":6,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.26-0177","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"value":"0002-9637","type":"print"},{"value":"1476-1645","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,5]]}}}