{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T13:20:48Z","timestamp":1788355248464,"version":"build-2803163510"},"reference-count":8,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,2]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n                  <jats:p>\n                    Sporotrichosis caused by\n                    <jats:italic>Sporothrix brasiliensis<\/jats:italic>\n                    is endemic in Brazil and may present with atypical clinical features. We report a case of verrucous sporotrichosis of the eyelid mimicking cutaneous leishmaniasis in a 28-year-old woman without cat exposure or trauma. Initial diagnostic studies were inconclusive, and prolonged treatment with oral itraconazole failed. Subsequent fungal culture and polymerase chain reaction established the diagnosis. Medication review revealed concomitant pantoprazole use, likely impairing itraconazole absorption through pH-dependent bioavailability. Lesion resolution occurred after a 3-month course of oral terbinafine. This case highlights two critical considerations: sporotrichosis should remain in the differential diagnosis of chronic verrucous lesions in endemic regions, and careful evaluation of drug\u2013drug interactions is essential to prevent antifungal treatment failure.\n                  <\/jats:p>","DOI":"10.4269\/ajtmh.26-0202","type":"journal-article","created":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T15:24:19Z","timestamp":1784215459000},"page":"578-580","source":"Crossref","is-referenced-by-count":0,"title":["Eyelid Verrucous Sporotrichosis Caused by Sporothrix Brasiliensis Mimicking Cutaneous Leishmaniasis and Complicated by Drug\u2013Drug Interaction"],"prefix":"10.4269","volume":"115","author":[{"given":"Felipe Tavares","family":"Rodrigues","sequence":"first","affiliation":[{"name":"Dermatology Department, State University of Rio de Janeiro (UERJ), Brazil;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda Ribeiro","family":"dos Santos","sequence":"additional","affiliation":[{"name":"Clinical and Toxicological Analyses Department, School of Pharmaceutical Sciences, S\u00e3o Paulo University (USP), Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandro Rog\u00e9rio","family":"de Almeida","sequence":"additional","affiliation":[{"name":"Clinical and Toxicological Analyses Department, School of Pharmaceutical Sciences, S\u00e3o Paulo University (USP), Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata Chaves","family":"Albuquerque","sequence":"additional","affiliation":[{"name":"Clinical and Toxicological Analyses Department, School of Pharmaceutical Sciences, S\u00e3o Paulo University (USP), Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Regina Casz","family":"Schechtman","sequence":"additional","affiliation":[{"name":"Dermatology Department, State University of Rio de Janeiro (UERJ), Brazil;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sueli","family":"Carneiro","sequence":"additional","affiliation":[{"name":"Dermatology Department, State University of Rio de Janeiro (UERJ), Brazil;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"issue":"4","key":"b1","series-title":"Clin Microbiol Rev","first-page":"633","article-title":"Sporothrix schenckii and sporotrichosis","volume":"24","author":"Barros","year":"2011"},{"issue":"8","key":"b2","series-title":"J Fungi","first-page":"776","article-title":"Current progress on epidemiology, diagnosis, and treatment of sporotrichosis and their future trends","volume":"8","author":"Rodrigues","year":"2022"},{"issue":"4","key":"b3","series-title":"Antimicrob Agents Chemother","first-page":"778","article-title":"Food interaction and steady-state pharmacokinetics of itraconazole capsules in healthy volunteers","volume":"37","author":"Barone","year":"1993"},{"issue":"6","key":"b4","series-title":"Clin Pharmacol Ther","first-page":"565","article-title":"Drug interactions with lipid-lowering drugs: Mechanisms and clinical relevance","volume":"80","author":"Neuvonen","year":"2006"},{"issue":"1","key":"b5","series-title":"An Bras Dermatol","first-page":"89","article-title":"Exuberant case of verrucous cutaneous leishmaniasis","volume":"97","author":"Novaes","year":"2022"},{"issue":"7","key":"b6","series-title":"J Dtsch Dermatol Ges","first-page":"793","article-title":"Recognising cutaneous tuberculosis","volume":"23","author":"Gramminger","year":"2025"},{"issue":"3","key":"b7","series-title":"Indian Dermatol Online J","first-page":"303","article-title":"Lymphocutaneous sporotrichosis of face with verrucous lesions: A case report","volume":"10","author":"Verma","year":"2019"},{"issue":"4","key":"b8","series-title":"Indian Dermatol Online J","first-page":"371","article-title":"Chromoblastomycosis: Report of two cases on face from urban industrial area","volume":"4","author":"Panicker","year":"2013"}],"container-title":["The American Journal of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/115\/3\/article-p578.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/115\/3\/article-p578.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/115\/3\/article-p578.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T12:54:25Z","timestamp":1788353665000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/115\/3\/article-p578.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,2]]},"references-count":8,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.26-0202","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"value":"0002-9637","type":"print"},{"value":"1476-1645","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,2]]}}}