{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T15:48:57Z","timestamp":1791906537835,"version":"4.3.4"},"reference-count":28,"publisher":"American Society of Tropical Medicine and Hygiene","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,13]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n                  <jats:p>\n                    Opisthorchiasis caused by\n                    <jats:italic>Opisthorchis viverrini<\/jats:italic>\n                    is a significant public health problem in northeast Thailand, a region where the prevalence of type 2 diabetes mellitus (T2DM) substantially exceeds the national average. Although recent evidence suggests that hyperglycemia may occur after praziquantel (PZQ) treatment, the underlying mechanisms remain poorly understood. We conducted a prospective 12-month follow-up study of 110\n                    <jats:italic>O. viverrini<\/jats:italic>\n                    -infected patients receiving PZQ treatment, assessing fasting plasma glucose (FPG), oral glucose tolerance test (OGTT), and fasting serum insulin (FSI) at baseline and 12 months posttreatment. Praziquantel treatment was associated with significant increases in FPG (87.4 \u00b1 1.0 versus 92.4 \u00b1 1.7 mg\/dL;\n                    <jats:italic>P<\/jats:italic>\n                    = 0.010), FSI (9.6 \u00b1 0.7 versus 13.4 \u00b1 1.1\n                    <jats:italic>\u00b5<\/jats:italic>\n                    U\/mL;\n                    <jats:italic>P<\/jats:italic>\n                    = 0.003), and homeostatic model assessment of insulin resistance (HOMA-IR; 2.2 \u00b1 0.2 versus 3.0 \u00b1 0.3;\n                    <jats:italic>P<\/jats:italic>\n                    = 0.001) at 12 months, whereas OGTT values did not differ significantly (\n                    <jats:italic>P<\/jats:italic>\n                    = 0.790). General linear model analysis identified age 50 years old and older and baseline obesity as significant factors associated with elevated FPG, whereas female sex, alcohol consumption, and baseline obesity correlated with higher OGTT values. Interestingly, HOMA-IR was significantly associated with underweight status at both baseline and follow-up. These findings suggest that\n                    <jats:italic>O. viverrini<\/jats:italic>\n                    eradication by PZQ increases insulin resistance in opisthorchiasis patients, potentially elevating T2DM risk. This effect likely reflects the loss of helminth-induced immunomodulation after parasite clearance, which is potentially compounded by improved appetite and increased food consumption after treatment, suggesting that metabolic surveillance should be integrated into liver fluke control programs.\n                  <\/jats:p>","DOI":"10.4269\/ajtmh.26-0222","type":"journal-article","created":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T15:20:45Z","timestamp":1791904845000},"source":"Crossref","is-referenced-by-count":0,"title":["Increased Insulin Resistance after Praziquantel Treatment in Human Opisthorchiasis"],"prefix":"10.4269","author":[{"given":"Hendra","family":"Kurniawan","sequence":"first","affiliation":[{"name":"Department of Tropical Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand;"},{"name":"Tropical Disease Research Center, Khon Kaen University, Khon Kaen, Thailand;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pornphutthachat","family":"Sota","sequence":"additional","affiliation":[{"name":"Tropical Disease Research Center, Khon Kaen University, Khon Kaen, Thailand;"},{"name":"School of Animal Technology and Innovation, Institute of Agricultural Technology, Suranaree University of Technology, Nakhon Ratchasima, Thailand;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eimorn","family":"Mairiang","sequence":"additional","affiliation":[{"name":"Department of Radiology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veerasak","family":"Punyapornwithaya","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine, Chiang Mai University, Chiang Mai, Thailand;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suranut","family":"Charoensri","sequence":"additional","affiliation":[{"name":"Department of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sutas","family":"Suttiprapa","sequence":"additional","affiliation":[{"name":"Department of Tropical Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand;"},{"name":"Tropical Disease Research Center, Khon Kaen University, Khon Kaen, Thailand;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sangduan","family":"Wannachart","sequence":"additional","affiliation":[{"name":"Tropical Disease Research Center, Khon Kaen University, Khon Kaen, Thailand;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pattapong","family":"Kessomboon","sequence":"additional","affiliation":[{"name":"Department of Community Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Banchob","family":"Sripa","sequence":"additional","affiliation":[{"name":"Department of Tropical Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand;"},{"name":"Tropical Disease Research Center, Khon Kaen University, Khon Kaen, Thailand;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"issue":"10267","key":"b1","series-title":"Lancet","first-page":"2019","article-title":"The Lancet Commission on diabetes: Using data to transform diabetes care and patient lives","volume":"396","author":"Chan","year":"2020"},{"key":"b2","series-title":"Diabetes Res Clin Pract","first-page":"109119","article-title":"IDF Diabetes Atlas: Global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045","volume":"183","author":"Sun","year":"2022"},{"key":"b3","article-title":"IDF Diabetes Atlas 10th Edition 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An exploration of their influence on macrophage and \u03b2-cell crosstalk","volume":"14","author":"Camaya","year":"2023"},{"issue":"6","key":"b26","series-title":"Am J Trop Med Hyg","first-page":"1265","article-title":"More evidence on the effects of deworming: What lessons can we learn?","volume":"96","author":"Croke","year":"2017"},{"key":"b27","series-title":"J Glob Health","first-page":"04002","article-title":"A comprehensive assessment of deworming coverage among pregnant women in low- and middle-income countries, 2000\u201330","volume":"14","author":"Sassa","year":"2024"},{"key":"b28","series-title":"F1000Res","first-page":"905","article-title":"Dietary patterns and their association with the components of metabolic syndrome: A cross-sectional study of adults from northeast Thailand","volume":"7","author":"Chupanit","year":"2018"}],"container-title":["The American Journal of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/aop\/article-10.4269-ajtmh.26-0222\/article-10.4269-ajtmh.26-0222.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/aop\/article-10.4269-ajtmh.26-0222\/article-10.4269-ajtmh.26-0222.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T15:20:45Z","timestamp":1791904845000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/aop\/article-10.4269-ajtmh.26-0222\/article-10.4269-ajtmh.26-0222.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,13]]},"references-count":28,"URL":"https:\/\/doi.org\/10.4269\/ajtmh.26-0222","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"value":"0002-9637","type":"print"},{"value":"1476-1645","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,13]]}}}