{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T15:39:46Z","timestamp":1792510786931,"version":"4.5.0"},"reference-count":86,"publisher":"American Society of Tropical Medicine and Hygiene","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,20]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n                  <jats:p>\n                    Snakebite envenoming is a serious and often neglected tropical disease associated with high mortality and disability rates. Local tissue injury is one of the main causes of long-term functional impairment after snakebite. Clinically, it may present as local hemorrhage, edema, myonecrosis, and tissue fibrosis. Accumulating evidence indicates that several venom components, including snake venom metalloproteinases, snake venom phospholipase A\n                    <jats:sub>2<\/jats:sub>\n                    s, three-finger toxins, and L-amino acid oxidases, are involved in local tissue injury. These toxins can induce direct cellular and microvascular damage. They can also trigger inflammatory responses, immune dysregulation, and oxidative stress. Compared with systemic toxicity, local tissue damage often has more persistent effects on patients. Antivenom is currently the main treatment of snakebite envenoming. It can neutralize venom toxins and reduce mortality. However, its effect on established local tissue injury remains limited. In recent years, several adjunctive therapies have shown potential. These include small-molecule enzyme inhibitors, photobiomodulation therapy, and stem cell-based therapies. However, most studies still lack sufficient clinical evidence. This review summarizes the major venom components involved in snakebite-induced local tissue injury, the underlying pathophysiological mechanisms, and potential therapeutic strategies. The aim of this review is to provide new perspectives for future mechanistic studies and clinical intervention.\n                  <\/jats:p>","DOI":"10.4269\/ajtmh.26-0353","type":"journal-article","created":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T14:50:38Z","timestamp":1792507838000},"source":"Crossref","is-referenced-by-count":0,"title":["Local Tissue Damage Induced by Snakebite Envenoming: Mechanisms and Therapeutic Advances"],"prefix":"10.4269","author":[{"given":"Jianbiao","family":"Luo","sequence":"first","affiliation":[{"name":"School of Traditional Chinese Medicine, Jiangxi University of Chinese Medicine, Nanchang, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenxin","family":"Xiong","sequence":"additional","affiliation":[{"name":"School of Traditional Chinese Medicine, Jiangxi University of Chinese Medicine, Nanchang, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiajie","family":"Gu","sequence":"additional","affiliation":[{"name":"School of Traditional Chinese Medicine, Jiangxi University of Chinese Medicine, Nanchang, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongsheng","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Traditional Chinese Surgery, The Affiliated Hospital of Jiangxi University of Chinese Medicine, Nanchang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianglong","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Traditional Chinese Surgery, The Affiliated Hospital of Jiangxi University of Chinese Medicine, Nanchang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanchun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Traditional Chinese Surgery, The Affiliated Hospital of Jiangxi University of Chinese Medicine, Nanchang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Degang","family":"Dong","sequence":"additional","affiliation":[{"name":"School of Traditional Chinese Medicine, Jiangxi University of Chinese Medicine, Nanchang, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"issue":"1","key":"b1","series-title":"N Engl J Med","first-page":"68","article-title":"Snake envenomation","volume":"386","author":"Seifert","year":"2022"},{"issue":"4","key":"b2","series-title":"PLoS Negl Trop Dis","first-page":"e0012080","article-title":"Snakebite envenoming: A systematic review and meta-analysis of global morbidity and mortality","volume":"18","author":"Afroz","year":"2024"},{"issue":"11","key":"b3","series-title":"Toxins (Basel)","first-page":"626","article-title":"Snakebite clinics and pathogenesis: From preclinical to resource mapping studies","volume":"15","author":"Pucca","year":"2023"},{"key":"b4","series-title":"Scars Burn Heal","first-page":"20595131221095348","article-title":"Is the future scarless?\u2014Fibroblasts as targets for scarless wound healing: A narrative review","volume":"8","author":"Parry","year":"2022"},{"issue":"5","key":"b5","series-title":"Toxins (Basel)","first-page":"313","article-title":"Prospecting local treatments used in conjunction with antivenom administration following envenomation caused by animals: A systematic review","volume":"15","author":"Carvalho","year":"2023"},{"key":"b6","series-title":"Front Pharmacol","first-page":"768015","article-title":"Investigating toxin diversity and abundance in snake venom proteomes","volume":"12","author":"Tasoulis","year":"2022"},{"issue":"1","key":"b7","series-title":"Arch Toxicol","first-page":"133","article-title":"A current perspective on snake venom composition and constituent protein families","volume":"97","author":"Tasoulis","year":"2023"},{"key":"b8","series-title":"Toxicon","first-page":"107317","article-title":"Proteomic characteristics of six snake venoms from the Viperidae and Elapidae families in China and their relation to local tissue necrosis","volume":"235","author":"Qin","year":"2023"},{"key":"b9","series-title":"Toxicon","first-page":"107532","article-title":"Proteome analysis of Daboia russelii venom, a medically important snake from the Indian sub-continent","volume":"237","author":"Yasmin","year":"2024"},{"issue":"12","key":"b10","series-title":"Toxins (Basel)","first-page":"791","article-title":"Size matters: An evaluation of the molecular basis of ontogenetic modifications in the composition of Bothrops jararacussu snake venom","volume":"12","author":"Freitas-de-Sousa","year":"2020"},{"key":"b11","series-title":"Toxicon","first-page":"106992","article-title":"Action of BjussuMP-II, a snake venom metalloproteinase isolated from Bothrops jararacussu venom, on human neutrophils","volume":"222","author":"K","year":"2023"},{"issue":"10","key":"b12","series-title":"Toxins (Basel)","first-page":"438","article-title":"The toxin diversity, cytotoxicity, and enzymatic activity of cape cobra (Naja nivea) venom","volume":"16","author":"L\u00fcddecke","year":"2024"},{"key":"b13","series-title":"Toxicon","first-page":"46","article-title":"Changes in basement membrane components in an experimental model of skeletal muscle degeneration and regeneration induced by snake venom and myotoxic phospholipase A2","volume":"192","author":"Escalante","year":"2021"},{"issue":"4","key":"b14","series-title":"Toxins (Basel)","first-page":"294","article-title":"Application of an extracellular matrix-mimicking fluorescent polymer for the detection of proteolytic venom toxins","volume":"15","author":"Wachtel","year":"2023"},{"issue":"2","key":"b15","series-title":"Biochem Soc Trans","first-page":"719","article-title":"Cytotoxicity of snake venom enzymatic toxins: Phospholipase A2 and l-amino acid oxidase","volume":"48","author":"Hiu","year":"2020"},{"issue":"6","key":"b16","series-title":"Mol Biol Evol","first-page":"msad125","article-title":"Comparative venom multiomics reveal the molecular mechanisms driving adaptation to diverse predator-prey ecosystems in closely related sea snakes","volume":"40","author":"Zheng","year":"2023"},{"issue":"11","key":"b17","series-title":"Toxins (Basel)","first-page":"802","article-title":"Inflammation and oxidative stress in snakebite envenomation: A brief descriptive review and clinical implications","volume":"14","author":"Resiere","year":"2022"},{"issue":"2","key":"b18","series-title":"Biomolecules","first-page":"154","article-title":"The versatility of serine proteases from Brazilian Bothrops venom: Their roles in snakebites and drug discovery","volume":"15","author":"Romanazzi","year":"2025"},{"issue":"2","key":"b19","series-title":"Toxins (Basel)","first-page":"68","article-title":"Amplification of snake venom toxicity by endogenous signaling pathways","volume":"12","author":"Bickler","year":"2020"},{"issue":"11","key":"b20","series-title":"Toxins (Basel)","first-page":"723","article-title":"A review of the proteomic profiling of African Viperidae and Elapidae snake venoms and their antivenom neutralisation","volume":"14","author":"Offor","year":"2022"},{"issue":"1","key":"b21","series-title":"J Med Case Rep","first-page":"65","article-title":"Diagnostic and therapeutic challenges into snakebite-induced thrombotic microangiopathy: A case report and review of the literature","volume":"20","author":"Panda","year":"2026"},{"issue":"5","key":"b22","series-title":"Trans R Soc Trop Med Hyg","first-page":"538","article-title":"Local swelling in snakebite envenomation: Are we missing something for want of a name?","volume":"119","author":"Kadhiravan","year":"2025"},{"key":"b23","series-title":"Toxicon","first-page":"107288","article-title":"Affected inflammation-related signaling pathways in snake envenomation: A recent insight","volume":"234","author":"Luo","year":"2023"},{"issue":"8","key":"b24","series-title":"Ann Med Surg (Lond)","first-page":"4832","article-title":"Compartment syndrome of arm secondary to snake bite on hand: A case report","volume":"86","author":"Dahal","year":"2024"},{"issue":"5","key":"b25","series-title":"Asian J Surg","first-page":"2512","article-title":"A case report of snakebite-causing skin and soft tissue necrosis over the right forearm","volume":"47","author":"Ge","year":"2024"},{"issue":"2","key":"b26","series-title":"Toxins (Basel)","first-page":"122","article-title":"Local cytotoxic effects in cobra envenoming: A pilot study","volume":"14","author":"Lin","year":"2022"},{"issue":"1","key":"b27","series-title":"Commun 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toxicity","volume":"26","author":"Dong","year":"2020"},{"issue":"1","key":"b48","series-title":"Cell Death Dis","first-page":"48","article-title":"Functional analyses and integrated mechanisms of cellular destruction by L-amino acid oxidase","volume":"17","author":"Prak","year":"2025"},{"key":"b49","series-title":"Biomed Pharmacother","first-page":"119017","article-title":"Pharmacological inhibition of myosin reduces the cytotoxic effect of a Lys49 PLA2-like myotoxin on human and rat cardiac muscle","volume":"195","author":"Agyapong","year":"2026"},{"issue":"6","key":"b50","series-title":"PLoS Negl Trop Dis","first-page":"e0010523","article-title":"Bothrops lanceolatus snake venom impairs mitochondrial respiration and induces DNA release in human heart preparation","volume":"16","author":"Cano-Sanchez","year":"2022"},{"issue":"2","key":"b51","series-title":"MedComm (2020)","first-page":"e70600","article-title":"Oxidative stress: Molecular mechanisms, diseases, and therapeutic 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Amazon","volume":"17","author":"Fern\u00e1ndez","year":"2025"},{"key":"b56","series-title":"Mediators Inflamm","first-page":"8285084","article-title":"CCL-2 and CXCL-8: Potential prognostic biomarkers of acute kidney injury after a Bothrops atrox snakebite","volume":"2022","author":"Neves","year":"2022"},{"issue":"1","key":"b57","series-title":"S Afr J Surg","first-page":"14","article-title":"Point-of-care ultrasound assessment of a swollen limb following snakebite envenomation\u2014An adjunct to avoid fasciotomy","volume":"61","author":"Smit","year":"2023"},{"issue":"6","key":"b58","series-title":"Toxins (Basel)","first-page":"276","article-title":"Investigating snake-venom-induced dermonecrosis and inflammation using an ex vivo human skin model","volume":"16","author":"Alsolaiss","year":"2024"},{"issue":"6","key":"b59","series-title":"Toxins (Basel)","first-page":"398","article-title":"Snake antivenoms\u2014Toward better understanding of the administration route","volume":"15","author":"Gamulin","year":"2023"},{"key":"b60","series-title":"Med Sci Monit","first-page":"4495","article-title":"Small incisions combined with negative-pressure wound therapy for treatment of Protobothrops mucrosquamatus bite envenomation: A new treatment strategy","volume":"25","author":"Zeng","year":"2019"},{"key":"b61","series-title":"J Clin Orthop Trauma","first-page":"101668","article-title":"Change in granulation tissue coverage and bacteriological load using low cost negative pressure wound therapy in acute musculoskeletal wounds","volume":"23","author":"Pathak","year":"2021"},{"issue":"7","key":"b62","series-title":"Biochim Biophys Acta Gen Subj","first-page":"129913","article-title":"The synthetic varespladib molecule is a multi-functional inhibitor for PLA2 and PLA2-like ophidic toxins","volume":"1865","author":"Salvador","year":"2021"},{"issue":"6","key":"b63","series-title":"Biomedicines","first-page":"165","article-title":"Varespladib inhibits the 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atrox.","volume":"12","author":"Layfield","year":"2020"},{"issue":"542","key":"b67","series-title":"Sci Transl Med","first-page":"eaay8314","article-title":"Preclinical validation of a repurposed metal chelator as an early-intervention therapeutic for hemotoxic snakebite","volume":"12","author":"Albulescu","year":"2020"},{"issue":"10","key":"b68","series-title":"J Neuropathol Exp Neurol","first-page":"816","article-title":"Inhibiting matrix metalloproteinases protects evoked electromyography amplitudes and muscle tension in the orbicularis oris muscle in a rat model of facial nerve injury","volume":"81","author":"Wu","year":"2022"},{"key":"b69","series-title":"Front Immunol","first-page":"612846","article-title":"A clot twist: Extreme variation in coagulotoxicity mechanisms in Mexican neotropical rattlesnake venoms","volume":"12","author":"Seneci","year":"2021"},{"issue":"7","key":"b70","series-title":"Toxins (Basel)","first-page":"451","article-title":"The search for natural and 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minimize exercise-induced oxidative stress? 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