{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T15:24:33Z","timestamp":1791559473074,"version":"4.3.4"},"reference-count":24,"publisher":"American Society of Tropical Medicine and Hygiene","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,17]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n                  <jats:p>\n                    Although artemether\u2013lumefantrine is a first-line treatment for uncomplicated\n                    <jats:italic>Plasmodium falciparum<\/jats:italic>\n                    (\n                    <jats:italic>P. falciparum<\/jats:italic>\n                    ) malaria, delayed hemolysis may occur after therapy. A previously healthy 39-year-old Japanese man developed\n                    <jats:italic>P. falciparum<\/jats:italic>\n                    malaria after traveling to Togo and was treated with artemether\u2013lumefantrine in the Philippines. Because fever and fatigue persisted after treatment, he presented to the study hospital and was diagnosed with delayed hemolysis induced by artemether\u2013lumefantrine. Supportive therapy, including blood transfusion, led to symptomatic improvement, and he was discharged. However, he was subsequently readmitted because of recrudescence of\n                    <jats:italic>P. falciparum<\/jats:italic>\n                    malaria accompanied by hemolytic anemia. Treatment with atovaquone\u2013proguanil resulted in clinical improvement. Because delayed hemolysis and recrudescence may develop after treatment of\n                    <jats:italic>P. falciparum<\/jats:italic>\n                    malaria with artemether\u2013lumefantrine, careful follow-up for at least 4 weeks after treatment with artemether\u2013lumefantrine should be considered.\n                  <\/jats:p>","DOI":"10.4269\/ajtmh.26-0364","type":"journal-article","created":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T16:23:13Z","timestamp":1789662193000},"source":"Crossref","is-referenced-by-count":1,"title":["Recurrent Plasmodium falciparum Malaria after Delayed Hemolysis Induced by Artemether\u2013Lumefantrine"],"prefix":"10.4269","author":[{"given":"Kosuke","family":"Asano","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan;"},{"name":"Department of General Medicine, The Jikei University School of Medicine West Medical Center, Tokyo, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tokio","family":"Hoshina","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan;"},{"name":"Center for Medical Entomology, The Jikei University School of Medicine, Tokyo, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomomi","family":"Miyamoto","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taichi","family":"Odagawa","sequence":"additional","affiliation":[{"name":"Department of Tropical Medicine, The Jikei University School of Medicine, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erisha","family":"Saiki","sequence":"additional","affiliation":[{"name":"Center for Medical Entomology, The Jikei University School of Medicine, Tokyo, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuya","family":"Horino","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirotaka","family":"Kanuka","sequence":"additional","affiliation":[{"name":"Center for Medical Entomology, The Jikei University School of Medicine, Tokyo, Japan;"},{"name":"Department of Tropical Medicine, The Jikei University School of Medicine, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaki","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department 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