{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T03:18:45Z","timestamp":1762917525167,"version":"build-2065373602"},"reference-count":39,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,4,2]]},"abstract":"<jats:p>Data of <jats:italic>Staphylococcus aureus<\/jats:italic> carriage in Indonesian hospitals are scarce. Therefore, the epidemiology of <jats:italic>S. aureus<\/jats:italic> among surgery patients in three academic hospitals in Indonesia was studied. In total, 366 of 1,502 (24.4%) patients carried <jats:italic>S. aureus<\/jats:italic>. The methicillin-resistant <jats:italic>S. aureus<\/jats:italic> (MRSA) carriage rate was 4.3%, whereas 1.5% of the patients carried Panton-Valentine leukocidin (PVL)-positive methicillin-sensitive <jats:italic>S. aureus<\/jats:italic> (MSSA). Semarang and Malang city (odds ratio [OR] 9.4 and OR 9.0), being male (OR 2.4), hospitalization for more than 5 days (OR 11.708), and antibiotic therapy during hospitalization (OR 2.6) were independent determinants for MRSA carriage, whereas prior hospitalization (OR 2.5) was the only one risk factor for PVL-positive MSSA carriage. Typing of MRSA strains by Raman spectroscopy showed three large clusters assigned type 21, 24, and 38, all corresponding to ST239-MRSA-SCC<jats:italic>mec<\/jats:italic> type III. In conclusion, MRSA and PVL-positive MSSA are present among patients in surgical wards in Indonesian academic hospitals.<\/jats:p>","DOI":"10.4269\/ajtmh.13-0734","type":"journal-article","created":{"date-parts":[[2014,2,25]],"date-time":"2014-02-25T02:58:54Z","timestamp":1393297134000},"page":"728-734","source":"Crossref","is-referenced-by-count":14,"title":["Epidemiology of Staphylococcus aureus Harboring the mecA or Panton-Valentine Leukocidin Genes in Hospitals in Java and Bali, Indonesia"],"prefix":"10.4269","volume":"90","author":[{"given":"Dewi","family":"Santosaningsih","sequence":"first","affiliation":[]},{"given":"Sanarto","family":"Santoso","sequence":"additional","affiliation":[]},{"given":"Nyoman S.","family":"Budayanti","sequence":"additional","affiliation":[]},{"given":"Kuntaman","family":"Kuntaman","sequence":"additional","affiliation":[]},{"given":"Endang S.","family":"Lestari","sequence":"additional","affiliation":[]},{"given":"Helmia","family":"Farida","sequence":"additional","affiliation":[]},{"given":"Rebriarina","family":"Hapsari","sequence":"additional","affiliation":[]},{"given":"Purnomo","family":"Hadi","sequence":"additional","affiliation":[]},{"given":"Winarto","family":"Winarto","sequence":"additional","affiliation":[]},{"given":"Catarina","family":"Milheiri\u00e7o","sequence":"additional","affiliation":[]},{"given":"Kees","family":"Maquelin","sequence":"additional","affiliation":[]},{"given":"Diana","family":"Willemse-Erix","sequence":"additional","affiliation":[]},{"given":"Alex","family":"van Belkum","sequence":"additional","affiliation":[]},{"given":"Juli\u00ebtte A.","family":"Severin","sequence":"additional","affiliation":[]},{"given":"Henri A.","family":"Verbrugh","sequence":"additional","affiliation":[]}],"member":"2795","reference":[{"key":"R1","series-title":"Clin Microbiol Rev","first-page":"505","article-title":"Nasal carriage of Staphylococcus aureus: epidemiology, underlying mechanisms, and associated risks","volume":"10","author":"Kluytmans","year":"1997"},{"key":"R2","series-title":"Rev Invest Clin","first-page":"98","article-title":"Methicillin-resistant Staphylococcus aureus at a general hospital: epidemiological overview between 2000 and 2007","volume":"61","author":"Alvarez","year":"2009"},{"key":"R3","series-title":"Diagn Microbiol Infect Dis","first-page":"296","article-title":"A novel molecular pattern for methicillin-resistant Staphylococcus aureus in Milwaukee, WI clinical isolates","volume":"63","author":"Burlage","year":"2009"},{"key":"R4","series-title":"J Microbiol Immunol Infect","first-page":"458","article-title":"Nasal carriage of Staphylococcus aureus among healthy adults","volume":"39","author":"Choi","year":"2006"},{"key":"R5","series-title":"Lancet","first-page":"874","article-title":"Emergence and resurgence of methicillin-resistant Staphylococcus aureus as a public health threat","volume":"368","author":"Grundmann","year":"2006"},{"key":"R6","series-title":"CMAJ","first-page":"627","article-title":"Hospital infection control strategies for vancomycin-resistant enterococcus, methicillin-resistant Staphylococcus aureus and Clostridium difficile","volume":"180","author":"Johnston","year":"2009"},{"key":"R7","series-title":"J Korean Med Sci","first-page":"604","article-title":"Molecular epidemiologic analysis of methicillin-resistant Staphylococcus aureus isolates from bacteremia and nasal colonization at 10 intensive care units: multicenter prospective study in Korea","volume":"26","author":"Kwon","year":"2011"},{"key":"R8","series-title":"Microb Drug Resist","first-page":"160","article-title":"An international multicenter study of antimicrobial resistance and typing of hospital Staphylococcus aureus isolates from 21 laboratories in 19 countries or states","volume":"10","author":"Zinn","year":"2004"},{"key":"R9","series-title":"Am J Infect Control","first-page":"93","article-title":"Methicillin-resistant Staphylococcus aureus transmission: the possible importance of unrecognized health care worker carriage","volume":"36","author":"Ben-David","year":"2008"},{"key":"R10","series-title":"CID","first-page":"776","article-title":"Methicillin-resistant Staphylococcus aureus (MRSA) nares colonization at hospital admission and its effect on subsequent MRSA infection","volume":"39","author":"Davis","year":"2004"},{"key":"R11","series-title":"Infect Control Hosp Epidemiol","first-page":"415","article-title":"Nosocomial transmission of methicillin-resistant Staphylococcus aureus: a blinded study to establish baseline acquisition rates","volume":"24","author":"Fishbain","year":"2003"},{"key":"R12","series-title":"Arch Intern Med","first-page":"1372","article-title":"Carriage of methicillin-resistant Staphylococcus aureus in home care settings: prevalence, duration, and transmission to household members","volume":"169","author":"Lucet","year":"2009"},{"key":"R13","series-title":"Infect Control Hosp Epidemiol","first-page":"600","article-title":"Risk factors for methicillin-resistant Staphylococcus aureus (MRSA) acquisition in roommate contacts of patients colonized or infected with MRSA in an acute-care hospital","volume":"29","author":"Moore","year":"2008"},{"key":"R14","series-title":"J Hosp Infect","first-page":"50","article-title":"Environmental contamination makes an important contribution to hospital infection","volume":"65","author":"Boyce","year":"2007"},{"key":"R15","series-title":"Infect Control Hosp Epidemiol","first-page":"127","article-title":"A study of the relationship between environmental contamination with methicillin-resistant Staphylococcus aureus (MRSA) and patients' acquisition of MRSA","volume":"27","author":"Hardy","year":"2006"},{"key":"R16","series-title":"J Hosp Infect","first-page":"187","article-title":"Environmental reservoirs of methicillin-resistant Staphylococcus aureus in isolation rooms: correlation with patient isolates and implications for hospital hygiene","volume":"62","author":"Sexton","year":"2006"},{"key":"R17","series-title":"Jpn J Infect Dis","first-page":"367","article-title":"Association between isolation sites of methicillin-resistant Staphylococcus aureus (MRSA) in patients with MRSA-positive body sites and MRSA contamination in their surrounding environmental surfaces","volume":"60","author":"Shigeharu","year":"2007"},{"key":"R18","series-title":"J Gerontol A Biol Sci Med Sci","first-page":"1152","article-title":"Risk factors for methicillin-resistant Staphylococcus aureus colonization in a geriatric rehabilitation hospital","volume":"62","author":"Aizen","year":"2007"},{"key":"R19","series-title":"Eur J Clin Microbiol Infect Dis","first-page":"45","article-title":"Antimicrobial resistance among commensal isolates of Escherichia coli and Staphylococcus aureus in the Indonesian population inside and outside hospitals","volume":"27","author":"Lestari","year":"2008"},{"key":"R20","series-title":"J Clin Microbiol","first-page":"1989","article-title":"Unusually high prevalence of Panton-Valentine leukocidin genes among methicillin-sensitive Staphylococcus aureus strains carried in the Indonesian population","volume":"46","author":"Severin","year":"2008"},{"key":"R21","series-title":"CID","first-page":"1128","article-title":"Involvement of Panton-Valentine leukocidin-producing Staphylococcus aureus in primary skin infections and pneumonia","volume":"29","author":"Lina","year":"1999"},{"key":"R22","series-title":"J Clin Invest","first-page":"1732","article-title":"Natural population dynamics and expansion of pathogenic clones of Staphylococcus aureus","volume":"114","author":"Melles","year":"2004"},{"key":"R23","series-title":"J Clin Microbiol","first-page":"2240","article-title":"Identification of methicillin-resistant strains of staphylococci by polymerase chain reaction","volume":"29","author":"Murakami","year":"1991"},{"key":"R24","series-title":"Antimicrob Agents Chemother","first-page":"3374","article-title":"Update to the multiplex PCR strategy for assignment of mec element types in Staphylococcus aureus","volume":"51","author":"Milheirico","year":"2007"},{"key":"R25","series-title":"J Clin Microbiol","first-page":"1434","article-title":"Good performance of SpectraCellRA system for typing of methicillin-resistant Staphylococcus aureus (MRSA)","volume":"51","author":"Te Witt","year":"2013"},{"key":"R26","series-title":"J Clin Microbiol","first-page":"652","article-title":"Optical fingerprinting in bacterial epidemiology: Raman spectroscopy as a real-time typing method","volume":"47","author":"Willemse-Erix","year":"2009"},{"key":"R27","series-title":"J Clin Microbiol","first-page":"1370","article-title":"Rapid typing of extended-spectrum beta-lactamase- and carbapenemase- producing Escherichia coli and Klebsiella pneumoniae isolates by use of spectraCell RA","volume":"50","author":"Willemse-Erix","year":"2012"},{"key":"R28","series-title":"J Clin Microbiol","first-page":"1008","article-title":"Multilocus sequence typing for characterization of methicillin-resistant and methicillin-susceptible clones of Staphylococcus aureus","volume":"38","author":"Enright","year":"2000"},{"key":"R29","series-title":"Trop Med Int Health","first-page":"1235","article-title":"Determinants of carriage of resistant Staphylococcus aureus among S. aureus carriers in the Indonesian population inside and outside hospitals","volume":"15","author":"Lestari","year":"2010"},{"key":"R30","series-title":"PLOS Computational Biology","first-page":"1","article-title":"Quantifying type-specific reproduction numbers for nosocomial pathogens: evidence for heightened transmission of an Asian sequence Type 239 MRSA clone","volume":"8","author":"Cooper","year":"2012"},{"key":"R31","series-title":"Antimicrob Agents Chemother","first-page":"5413","article-title":"Nasal carriage of methicillin-resistant and methicillin sensitive strains of Staphylococcus sciuri in the Indonesian population: epidemiology and risk factors","volume":"54","author":"Severin","year":"2010"},{"key":"R32","series-title":"Eur J Clin Microbiol Infect Dis","first-page":"977","article-title":"MRSA carriage in a tertiary governmental hospital in Thailand: emphasis on prevalence and molecular epidemiology","volume":"29","author":"Jariyasethpong","year":"2010"},{"key":"R33","series-title":"Indian J Med Microbiol","first-page":"62","article-title":"Screening for methicillin-resistant Staphylococcus aureus carriers among patients and health care workers of a tertiary care hospital in south India","volume":"27","author":"Mathanraj","year":"2009"},{"key":"R34","series-title":"Future Microbiol","first-page":"999","article-title":"Staphylococcus aureus nasal carriage and its contributing factors","volume":"4","author":"Sivaraman","year":"2009"},{"key":"R35","series-title":"Antimicrob Agents Chemother","first-page":"4264","article-title":"Antibiotic usage and risk of colonization and infection with antibiotic-resistant bacteria a hospital population-based study","volume":"53","author":"Tacconelli","year":"2009"},{"key":"R36","series-title":"Clin Microbiol Infect","first-page":"92","article-title":"Molecular typing of methicillin-susceptible Staphylococcus aureus isolates collected in the Yogyakarta area in Indonesia, 2006","volume":"16","author":"Deurenberg","year":"2010"},{"key":"R37","series-title":"Int J Infect Dis","first-page":"e131","article-title":"Prevalence of Panton-Valentine leukocidin genes among carriage and invasive Staphylococcus aureus isolates in Malaysia","volume":"13","author":"Neela","year":"2009"},{"key":"R38","series-title":"Lab Invest","first-page":"3","article-title":"Community-acquired methicillin-resistant Staphylococcus aureus: the role of Panton-Valentine leukocidin","volume":"87","author":"Boyle-Vavra","year":"2007"},{"key":"R39","series-title":"PLOS Comput Biol","first-page":"1","article-title":"Cost and effects of different admission screening strategies to control the spread of methicillin-resistant Staphylococcus aureus","volume":"9","author":"Gurieva","year":"2013"}],"container-title":["The American Society of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/90\/4\/article-p728.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/90\/4\/article-p728.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/90\/4\/article-p728.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T21:28:26Z","timestamp":1723066106000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/90\/4\/article-p728.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,4,2]]},"references-count":39,"journal-issue":{"issue":"4"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.13-0734","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"type":"print","value":"0002-9637"},{"type":"electronic","value":"1476-1645"}],"subject":[],"published":{"date-parts":[[2014,4,2]]}}}