{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T12:48:37Z","timestamp":1773924517590,"version":"3.50.1"},"reference-count":18,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,6,3]]},"abstract":"<jats:p>Artemisinin-resistant <jats:italic>Plasmodium falciparum<\/jats:italic> malaria has been documented in southeast Asia and may already be spreading in that region. Molecular markers are important tools for monitoring the spread of antimalarial drug resistance. Recently, single-nucleotide polymorphisms (SNPs) in the PF3D7_1343700 kelch propeller (K13-propeller) domain were shown to be associated with artemisinin resistance <jats:italic>in vivo<\/jats:italic> and <jats:italic>in vitro<\/jats:italic>. The prevalence and role of K13-propeller mutations are poorly known in sub-Saharan Africa. K13-propeller mutations were genotyped by direct sequencing of nested polymerase chain reaction (PCR) amplicons from dried blood spots of pre-treatment falciparum malaria infections collected before and after the use of artemisinin-based combination therapy (ACT) as first-line therapy in Mali. Although K13-propeller mutations previously associated with delayed parasite clearance in Cambodia were not identified, 26 K13-propeller mutations were identified in both recent samples and pre-ACT infections. Parasite clearance time was comparable between infections with non-synonymous K13-propeller mutations and infections with the reference allele. These findings suggest that K13-propeller mutations are present in artemisinin-sensitive parasites and that they preceded the wide use of ACTs in Mali.<\/jats:p>","DOI":"10.4269\/ajtmh.14-0605","type":"journal-article","created":{"date-parts":[[2015,4,28]],"date-time":"2015-04-28T02:21:46Z","timestamp":1430187706000},"page":"1202-1206","source":"Crossref","is-referenced-by-count":82,"title":["Polymorphisms in the K13-Propeller Gene in Artemisinin-Susceptible Plasmodium falciparum Parasites from Bougoula-Hameau and Bandiagara, Mali"],"prefix":"10.4269","volume":"92","author":[{"given":"Amed","family":"Ouattara","sequence":"first","affiliation":[]},{"given":"Aminatou","family":"Kone","sequence":"additional","affiliation":[]},{"given":"Matthew","family":"Adams","sequence":"additional","affiliation":[]},{"given":"Bakary","family":"Fofana","sequence":"additional","affiliation":[]},{"given":"Amelia Walling","family":"Maiga","sequence":"additional","affiliation":[]},{"given":"Shay","family":"Hampton","sequence":"additional","affiliation":[]},{"given":"Drissa","family":"Coulibaly","sequence":"additional","affiliation":[]},{"given":"Mahamadou A.","family":"Thera","sequence":"additional","affiliation":[]},{"given":"Nouhoum","family":"Diallo","sequence":"additional","affiliation":[]},{"given":"Antoine","family":"Dara","sequence":"additional","affiliation":[]},{"given":"Issaka","family":"Sagara","sequence":"additional","affiliation":[]},{"given":"Jose Pedro","family":"Gil","sequence":"additional","affiliation":[]},{"given":"Anders","family":"Bjorkman","sequence":"additional","affiliation":[]},{"given":"Shannon","family":"Takala-Harrison","sequence":"additional","affiliation":[]},{"given":"Ogobara K.","family":"Doumbo","sequence":"additional","affiliation":[]},{"given":"Christopher V.","family":"Plowe","sequence":"additional","affiliation":[]},{"given":"Abdoulaye A.","family":"Djimde","sequence":"additional","affiliation":[]}],"member":"2795","reference":[{"key":"R1","series-title":"Am J Trop Med Hyg","first-page":"455","article-title":"Efficacy, safety, and selection of molecular markers of drug resistance by two ACTs in Mali","volume":"78","author":"Djimde","year":"2008"},{"key":"R2","series-title":"J Clin Invest","first-page":"2496","article-title":"The impact of malaria parasitism: from corpuscles to communities","volume":"119","author":"Wellems","year":"2009"},{"key":"R3","series-title":"Jpn J Infect Dis","first-page":"465","article-title":"Evolution of Plasmodium falciparum drug resistance: implications for the development and containment of artemisinin resistance","volume":"65","author":"Mita","year":"2012"},{"key":"R4","series-title":"Nature","first-page":"50","article-title":"A molecular marker of artemisinin-resistant Plasmodium falciparum 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proteostasis regulation during redox imbalance","volume":"2","author":"Niforou","year":"2014"},{"key":"R18","series-title":"Int J Parasitol","first-page":"163","article-title":"Oxidative stress in malaria parasite-infected erythrocytes: host-parasite interactions","volume":"34","author":"Becker","year":"2004"}],"container-title":["The American Society of Tropical Medicine and 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