{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T17:19:43Z","timestamp":1771262383540,"version":"3.50.1"},"reference-count":28,"publisher":"Galenos Yayinevi","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["dir"],"DOI":"10.4274\/dir.2025.243132","type":"journal-article","created":{"date-parts":[[2025,3,18]],"date-time":"2025-03-18T11:57:53Z","timestamp":1742299073000},"source":"Crossref","is-referenced-by-count":2,"title":["Dual-energy computed tomography-based volumetric thyroid iodine quantification: correlation with thyroid hormonal status, pathologic diagnosis, and phantom validation"],"prefix":"10.4274","author":[{"given":"Younghen","family":"Lee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2811","published-online":{"date-parts":[[2025,3,18]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"1. Chung HR. Iodine and thyroid function. Ann Pediatr Endocrinol Metab. 2014;19(1):8-12. [Crossref]","DOI":"10.6065\/apem.2014.19.1.8"},{"key":"ref1","doi-asserted-by":"publisher","unstructured":"2. Iida Y, Konishi J, Harioka T, Misaki T, Endo K, Torizuka K. Thyroid CT number and its relationship to iodine concentration. Radiology. 1983;147(3):793-795. [Crossref]","DOI":"10.1148\/radiology.147.3.6844615"},{"key":"ref2","doi-asserted-by":"publisher","unstructured":"3. Imanishi Y, Ehara N, Shinagawa T, et al. Correlation of CT values, iodine concentration, and histological changes in the thyroid. J Comput Assist Tomogr. 2000;24(2):322-326. [Crossref]","DOI":"10.1097\/00004728-200003000-00026"},{"key":"ref3","doi-asserted-by":"publisher","unstructured":"4. Pandey V, Reis M, Zhou Y. Correlation between computed tomography density and functional status of the thyroid gland. J Comput Assist Tomogr. 2016;40(2):316-319. [Crossref]","DOI":"10.1097\/RCT.0000000000000360"},{"key":"ref4","doi-asserted-by":"publisher","unstructured":"5. Silverman PM, Newman GE, Korobkin M, Workman JB, Moore AV, Coleman RE. Computed tomography in the evaluation of thyroid disease. AJR Am J Roentgenol. 1984;142(5):897-902. [Crossref]","DOI":"10.2214\/ajr.142.5.897"},{"key":"ref5","doi-asserted-by":"publisher","unstructured":"6. Han YM, Kim YC, Park EK, Choe JG. Diagnostic value of CT density in patients with diffusely increased FDG uptake in the thyroid gland on PET\/CT images. AJR Am J Roentgenol. 2010;195(1):223-228. [Crossref]","DOI":"10.2214\/AJR.09.3319"},{"key":"ref6","doi-asserted-by":"publisher","unstructured":"7. McCollough CH, Leng S, Yu L, Fletcher JG. Dual- and multi-energy CT: principles, technical approaches, and clinical applications. Radiology. 2015;276(3):637-653. [Crossref]","DOI":"10.1148\/radiol.2015142631"},{"key":"ref7","doi-asserted-by":"publisher","unstructured":"8. Forghani R, De Man B, Gupta R. Dual-energy computed tomography: physical principles, approaches to scanning, usage, and implementation: part 1. Neuroimaging Clin N Am. 2017;27(3):371-384. [Crossref]","DOI":"10.1016\/j.nic.2017.03.002"},{"key":"ref8","doi-asserted-by":"publisher","unstructured":"9. Takeda T, Yu Q, Yashiro T, et al. Iodine imaging in thyroid by fluorescent X-ray CT with 0.05 Mm spatial resolution. Nucl Instrum Meth A. 2001;467:1318-1321. [Crossref]","DOI":"10.1016\/S0168-9002(01)00654-4"},{"key":"ref9","doi-asserted-by":"publisher","unstructured":"10. Milakovic M, Berg G, Eggertsen R, et al. Determination of intrathyroidal iodine by X-ray fluorescence analysis in 60- to 65-year olds living in an iodine-sufficient area. J Intern Med. 2006;260(1):69-75. [Crossref]","DOI":"10.1111\/j.1365-2796.2006.01660.x"},{"key":"ref10","doi-asserted-by":"publisher","unstructured":"11. Duan X, Arbique G, Guild J, Xi Y, Anderson J. Technical note: quantitative accuracy evaluation for spectral images from a detector-based spectral CT scanner using an iodine phantom. Med Phys. 2018;45(5):2048-2053. [Crossref]","DOI":"10.1002\/mp.12834"},{"key":"ref11","doi-asserted-by":"publisher","unstructured":"12. Hua CH, Shapira N, Merchant TE, Klahr P, Yagil Y. Accuracy of electron density, effective atomic number, and iodine concentration determination with a dual-layer dual-energy computed tomography system. Med Phys. 2018;45(6):2486-2497. [Crossref]","DOI":"10.1002\/mp.12903"},{"key":"ref12","doi-asserted-by":"publisher","unstructured":"13. So A, Nicolaou S. Spectral computed tomography: fundamental principles and recent developments. Korean J Radiol. 2021;22(1):86-96. [Crossref]","DOI":"10.3348\/kjr.2020.0144"},{"key":"ref13","doi-asserted-by":"publisher","unstructured":"14. Binh DD, Nakajima T, Otake H, Higuchi T, Tsushima Y. Iodine concentration calculated by dual-energy computed tomography (DECT) as a functional parameter to evaluate thyroid metabolism in patients with hyperthyroidism. BMC Med Imaging. 2017;17(1):43. [Crossref]","DOI":"10.1186\/s12880-017-0216-6"},{"key":"ref14","doi-asserted-by":"publisher","unstructured":"15. Shao W, Liu J, Liu D. Evaluation of energy spectrum CT for the measurement of thyroid iodine content. BMC Med Imaging. 2016;16(1):47. [Crossref]","DOI":"10.1186\/s12880-016-0151-y"},{"key":"ref15","doi-asserted-by":"publisher","unstructured":"16. Li ZT, Zhai R, Liu HM, Wang M, Pan DM. Iodine concentration and content measured by dual-source computed tomography are correlated to thyroid hormone levels in euthyroid patients: a cross-sectional study in China. BMC Med Imaging. 2020;20(1):10. [Crossref]","DOI":"10.1186\/s12880-020-0411-8"},{"key":"ref16","doi-asserted-by":"publisher","unstructured":"17. Ha EJ, Chung SR, Na DG, et al. 2021 Korean Thyroid imaging reporting and data system and imaging-based management of thyroid nodules: Korean Society of Thyroid Radiology Consensus Statement and Recommendations. Korean J Radiol. 2021;22(12):2094-2123. [Crossref]","DOI":"10.3348\/kjr.2021.0713"},{"key":"ref17","doi-asserted-by":"publisher","unstructured":"18. Soh SB, Aw TC. Laboratory testing in thyroid conditions - pitfalls and clinical utility. Ann Lab Med. 2019;39(1):3-14. [Crossref]","DOI":"10.3343\/alm.2019.39.1.3"},{"key":"ref18","unstructured":"19. Nikiforov YE, Biddinger PW, Thompson LDR. Diagnostic Pathology and Molecular Genetics of the Thyroid : A Comprehensive Guide for practicing phyroid pathology. 3rd ed., Wolters Kluwer Health; 2018. [Crossref]"},{"key":"ref19","unstructured":"20. User guide for Gammex tissue characterization phantom model 467. [Crossref]"},{"key":"ref20","unstructured":"21. Ahad F, Ganie SA. Iodine, iodine metabolism and Iodine deficiency disorders revisited. Indian J Endocrinol Metab. 2010;14(1):13-17. [Crossref]"},{"key":"ref21","doi-asserted-by":"publisher","unstructured":"22. Lennartz S, Parakh A, Cao J, et al. Inter-scan and inter-scanner variation of quantitative dual-energy CT: evaluation with three different scanner types. Eur Radiol. 2021;31(7):4438-4451. [Crossref]","DOI":"10.1007\/s00330-020-07611-0"},{"key":"ref22","doi-asserted-by":"publisher","unstructured":"23. Zopfs D, Graffe J, Reimer RP, et al. Quantitative distribution of iodinated contrast media in body computed tomography: data from a large reference cohort. Eur Radiol. 2021;31(4):2340-2348. [Crossref]","DOI":"10.1007\/s00330-020-07298-3"},{"key":"ref23","unstructured":"24. Bauer DC, McPhee SJ. Thyroid Disease. In: Hammer GD, McPhee SJ, editors. Pathophysiology of Disease: An Introduction to Clinical Medicine, 7e. New York, NY: McGraw-Hill Education; 2013. [Crossref]"},{"key":"ref24","doi-asserted-by":"publisher","unstructured":"25. Guan H, de Morais NS, Stuart J, et al. Discordance of serological and sonographic markers for Hashimoto's thyroiditis with gold standard histopathology. Eur J Endocrinol. 2019;181(5):539-544. [Crossref]","DOI":"10.1530\/EJE-19-0424"},{"key":"ref25","doi-asserted-by":"publisher","unstructured":"26. Ahn HS, Kim DW, Lee YJ, Baek HJ, Ryu JH. Diagnostic accuracy of real-time sonography in differentiating diffuse thyroid disease from normal thyroid parenchyma: a multicenter study. AJR Am J Roentgenol. 2018;211(3):649-654. [Crossref]","DOI":"10.2214\/AJR.17.19164"},{"key":"ref26","doi-asserted-by":"publisher","unstructured":"27. Spencer CA. Laboratory thyroid tests: a historical perspective. Thyroid. 2023;33(4):407-419. [Crossref]","DOI":"10.1089\/thy.2022.0397"},{"key":"ref27","doi-asserted-by":"publisher","unstructured":"28. Kanatani R, Shirasaka T, Kojima T, Kato T, Kawakubo M. Influence of beam hardening in dual-energy CT imaging: phantom study for iodine mapping, virtual monoenergetic imaging, and virtual non-contrast imaging. Eur Radiol Exp. 2021;5(1):18. [Crossref]","DOI":"10.1186\/s41747-021-00217-1"}],"container-title":["Diagnostic and Interventional Radiology"],"original-title":[],"deposited":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T07:08:20Z","timestamp":1750144100000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dirjournal.org\/articles\/dual-energy-computed-tomography-based-volumetric-thyroid-iodine-quantification-correlation-with-thyroid-hormonal-status-pathologic-diagnosis-and-phantom-validation\/doi\/dir.2025.243132"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,18]]},"references-count":28,"URL":"https:\/\/doi.org\/10.4274\/dir.2025.243132","relation":{},"ISSN":["1305-3825","1305-3612"],"issn-type":[{"value":"1305-3825","type":"print"},{"value":"1305-3612","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,18]]}}}