{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T08:02:29Z","timestamp":1789632149154,"version":"build-2803163510"},"reference-count":16,"publisher":"Galenos Yayinevi","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["dir"],"DOI":"10.4274\/dir.2026.263687","type":"journal-article","created":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T08:47:16Z","timestamp":1770194836000},"source":"Crossref","is-referenced-by-count":0,"title":["Microvascular dysfunction in patients with transthyretin cardiac amyloidosis evaluated by 13N-ammonia positron emission tomography\u2013computed tomography: is it an early marker of the disease?"],"prefix":"10.4274","author":[{"given":"Arist\u00f3teles","family":"Neto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caio","family":"Cafezeiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Bueno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristhian Espinoza","family":"Romero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vitor Emer","family":"Rosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viviane","family":"Hotta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camila de Godoi","family":"Carneiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Rochitte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vagner","family":"Madrini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose","family":"Soares","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Chalela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcos","family":"Lima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Buchpiguel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward","family":"Miller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Fernandes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2811","published-online":{"date-parts":[[2026,2,4]]},"reference":[{"issue":"22","key":"ref0","doi-asserted-by":"publisher","first-page":"2872","DOI":"10.1016\/j.jacc.2019.04.003","article-title":"Transthyretin amyloid cardiomyopathy: JACC State-of-the-Art Review","volume":"73","author":"Ruberg","year":"2019","unstructured":"1. Ruberg FL, Grogan M, Hanna M, Kelly JW, Maurer MS. Transthyretin amyloid cardiomyopathy: JACC State-of-the-Art Review. J Am Coll Cardiol. 2019;73(22):2872-2891.","journal-title":"J Am Coll Cardiol"},{"issue":"4","key":"ref1","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1177\/000331970105200407","article-title":"Cardiac amyloidosis presenting as microvascular angi-na--a case report","volume":"52","author":"Ogawa","year":"2001","unstructured":"2. Ogawa H, Mizuno Y, Ohkawara S, et al. Cardiac amyloidosis presenting as microvascular angi-na--a case report. Angiology. 2001;52(4):273-278.","journal-title":"Angiology"},{"issue":"11","key":"ref2","doi-asserted-by":"publisher","first-page":"838","DOI":"10.7326\/0003-4819-131-11-199912070-00007","article-title":"Systemic amyloidosis presenting with angina pector-is","volume":"131","author":"Al Suwaidi","year":"1999","unstructured":"3. Al Suwaidi J, Velianou JL, Gertz MA, et al. Systemic amyloidosis presenting with angina pector-is. Ann Intern Med. 1999;131(11):838-841.","journal-title":"Ann Intern Med"},{"key":"ref3","doi-asserted-by":"publisher","unstructured":"4. Whitaker DC, Tungekar MF, Dussek JE. Angina with a normal coronary angiogram caused by amyloidosis. Heart. 2004;90(9):e54.","DOI":"10.1136\/hrt.2004.038984"},{"issue":"12","key":"ref4","doi-asserted-by":"publisher","first-page":"2948","DOI":"10.1002\/ejhf.3481","article-title":"Microvascular obstruction in cardiac amyloido-sis","volume":"27","author":"Netti","year":"2025","unstructured":"5. Netti L, Ioannou A, Martinez-Naharro A, et al. Microvascular obstruction in cardiac amyloido-sis. Eur J Heart Fail. 2025;27(12):2948-2951.","journal-title":"Eur J Heart Fail"},{"issue":"4","key":"ref5","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1016\/j.jchf.2014.03.009","article-title":"Coronary microvascular dysfunction is related to ab-normalities in myocardial structure and function in cardiac amyloidosis","volume":"2","author":"Dorbala","year":"2014","unstructured":"6. Dorbala S, Vangala D, Bruyere J Jr, et al. Coronary microvascular dysfunction is related to ab-normalities in myocardial structure and function in cardiac amyloidosis. JACC Heart Fail. 2014;2(4):358-367.","journal-title":"JACC Heart Fail"},{"issue":"3","key":"ref6","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1016\/j.jacc.2003.08.043","article-title":"Noninvasive diagnosis of biopsy-proven cardiac am-yloidosis","volume":"43","author":"Rahman","year":"2004","unstructured":"7. Rahman JE, Helou EF, Gelzer-Bell R, et al. Noninvasive diagnosis of biopsy-proven cardiac am-yloidosis. J Am Coll Cardiol. 2004;43(3):410-415.","journal-title":"J Am Coll Cardiol"},{"issue":"12","key":"ref7","doi-asserted-by":"publisher","first-page":"1323","DOI":"10.1016\/j.jacc.2016.06.053","article-title":"AL (Light-Chain) Cardiac Amyloidosis: a review of diagnosis and therapy","volume":"68","author":"Falk","year":"2016","unstructured":"8. Falk RH, Alexander KM, Liao R, Dorbala S. AL (Light-Chain) Cardiac Amyloidosis: a review of diagnosis and therapy. J Am Coll Cardiol. 2016;68(12):1323-1341.","journal-title":"J Am Coll Cardiol"},{"issue":"21","key":"ref8","doi-asserted-by":"publisher","first-page":"2451","DOI":"10.1016\/j.jacc.2015.09.075","article-title":"Diagnosis, prognosis, and therapy of transthyretin amy-loidosis","volume":"66","author":"Gertz","year":"2015","unstructured":"9. Gertz MA, Benson MD, Dyck PJ, et al. Diagnosis, prognosis, and therapy of transthyretin amy-loidosis. J Am Coll Cardiol. 2015;66(21):2451-2466.","journal-title":"J Am Coll Cardiol"},{"issue":"4","key":"ref9","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1161\/hc0402.102975","article-title":"A statement for healthcare professionals from the Cardiac Imaging Committee of the Council on Clinical Cardiology of the American Heart Association","volume":"105","author":"Cerqueira","year":"2002","unstructured":"10. Cerqueira MD, Weissman NJ, Dilsizian V, et al. Standardized myocardial segmentation and nomenclature for tomographic imaging of the heart. A statement for healthcare professionals from the Cardiac Imaging Committee of the Council on Clinical Cardiology of the American Heart Association. Circulation. 2002;105(4):539-542.","journal-title":"Circulation"},{"issue":"5","key":"ref10","doi-asserted-by":"publisher","first-page":"1187","DOI":"10.1007\/s12350-016-0522-3","article-title":"ASNC imaging guidelines\/SNMMI procedure standard for positron emission tomography (PET) nuclear cardiology procedures","volume":"23","author":"Dilsizian","year":"2016","unstructured":"11. Dilsizian V, Bacharach SL, Beanlands RS, et al. ASNC imaging guidelines\/SNMMI procedure standard for positron emission tomography (PET) nuclear cardiology procedures. J Nucl Cardi-ol. 2016;23(5):1187-1226.","journal-title":"J Nucl Cardi-ol"},{"key":"ref11","unstructured":"12. Goss-Sampson M. Statistical Analysis in JASP - A Students Guide v0.10.2. [Internet]. figshare; 2019."},{"issue":"2","key":"ref12","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1016\/j.jacc.2009.02.069","article-title":"Long-term prognostic value of 13N-ammonia myocar-dial perfusion positron emission tomography added value of coronary flow reserve","volume":"54","author":"Herzog","year":"2009","unstructured":"13. Herzog BA, Husmann L, Valenta I, et al. Long-term prognostic value of 13N-ammonia myocar-dial perfusion positron emission tomography added value of coronary flow reserve. J Am Coll Cardiol. 2009;54(2):150-156.","journal-title":"J Am Coll Cardiol"},{"issue":"8","key":"ref13","doi-asserted-by":"publisher","first-page":"1230","DOI":"10.2967\/jnumed.111.101840","article-title":"Diagnostic value of 13N-ammonia myocardial perfu-sion PET: added value of myocardial flow reserve","volume":"53","author":"Fiechter","year":"2012","unstructured":"14. Fiechter M, Ghadri JR, Gebhard C, et al. Diagnostic value of 13N-ammonia myocardial perfu-sion PET: added value of myocardial flow reserve. J Nucl Med. 2012;53(8):1230-1234.","journal-title":"J Nucl Med"},{"issue":"4","key":"ref14","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1016\/j.jcmg.2009.11.013","article-title":"Prognostic significance of strain Doppler imaging in light-chain amyloido-sis","volume":"3","author":"Koyama","year":"2010","unstructured":"15. Koyama J, Falk RH. Prognostic significance of strain Doppler imaging in light-chain amyloido-sis. JACC Cardiovasc Imaging. 2010;3(4):333-342.","journal-title":"JACC Cardiovasc Imaging"},{"issue":"3","key":"ref15","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/S0002-9343(00)00471-X","article-title":"Symptomatic ischemic heart disease resulting from ob-structive intramural coronary amyloidosis","volume":"109","author":"Mueller","year":"2000","unstructured":"16. Mueller PS, Edwards WD, Gertz MA. Symptomatic ischemic heart disease resulting from ob-structive intramural coronary amyloidosis. Am J Med. 2000;109(3):181-188.","journal-title":"Am J Med"}],"container-title":["Diagnostic and Interventional Radiology"],"original-title":[],"deposited":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T07:08:51Z","timestamp":1789628931000},"score":1,"resource":{"primary":{"URL":"https:\/\/dirjournal.org\/articles\/microvascular-dysfunction-in-patients-with-transthyretin-cardiac-amyloidosis-evaluated-by-13n-ammonia-positron-emission-tomography-computed-tomography-is-it-an-early-marker-of-the-disease\/doi\/dir.2026.263687"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,4]]},"references-count":16,"URL":"https:\/\/doi.org\/10.4274\/dir.2026.263687","relation":{},"ISSN":["1305-3825","1305-3612"],"issn-type":[{"value":"1305-3825","type":"print"},{"value":"1305-3612","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,4]]}}}