{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T21:12:28Z","timestamp":1781557948050,"version":"3.54.5"},"reference-count":27,"publisher":"Galenos Yayinevi","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["tjod"],"published-print":{"date-parts":[[2023,6,1]]},"DOI":"10.4274\/tjod.galenos.2023.15098","type":"journal-article","created":{"date-parts":[[2023,6,2]],"date-time":"2023-06-02T05:57:31Z","timestamp":1685685451000},"page":"142-153","source":"Crossref","is-referenced-by-count":5,"title":["Efficacy and safety of rectal misoprostol versus intravenous oxytocin on reducing blood loss in cesarean section: A PRISMA-compliant systematic review and meta-analysis of randomized clinical trials"],"prefix":"10.4274","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1244-7769","authenticated-orcid":false,"given":"Ebraheem","family":"Albazee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3964-3778","authenticated-orcid":false,"given":"Ahmed","family":"Soliman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1462-4204","authenticated-orcid":false,"given":"Khaled","family":"Albakri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4386-5322","authenticated-orcid":false,"given":"Mohamed","family":"Elbanna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0133-0525","authenticated-orcid":false,"given":"Nada Alaa","family":"Moussa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4485-6735","authenticated-orcid":false,"given":"Hazem Metwally","family":"Faragalla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2811","published-online":{"date-parts":[[2023,6,1]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"1. Adane D, Belay G, Arega A, Wassihun B, Gedefaw G, Gebayehu K. Practice and factors associated with active management of third stage of labor among obstetric care providers in Amhara region referral hospitals, North Ethiopia, 2018: A cross sectional study. PLoS One 2019;14:e0222843.","DOI":"10.1371\/journal.pone.0222843"},{"key":"ref1","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.ejogrb.2015.12.012","article-title":"Postpartum hemorrhage: guidelines for clinical practice from the French College of Gynaecologists and Obstetricians (CNGOF): in collaboration with the French Society of Anesthesiology and Intensive Care (SFAR)","volume":"198","author":"Sentilhes","year":"2016","unstructured":"2. Sentilhes L, Vayssi\u00e8re C, Deneux-Tharaux C, Aya AG, Bayoumeu F, Bonnet MP, et al. Postpartum hemorrhage: guidelines for clinical practice from the French College of Gynaecologists and Obstetricians (CNGOF): in collaboration with the French Society of Anesthesiology and Intensive Care (SFAR). Eur J Obstet Gynecol Reprod Biol 2016;198:12-21.","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1186\/1756-0500-6-236","article-title":"\"Post partum hemorrhage: causes and management\"","volume":"6","author":"Edhi","year":"2013","unstructured":"3. Edhi MM, Aslam HM, Naqvi Z, Hashmi H. \"Post partum hemorrhage: causes and management\". BMC Res Notes 2013;6:236.","journal-title":"BMC Res Notes"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1111\/j.1365-3016.2007.00786.x","article-title":"Rates of caesarean section: analysis of global, regional and national estimates","volume":"21","author":"Betr\u00e1n","year":"2007","unstructured":"4. Betr\u00e1n AP, Merialdi M, Lauer JA, Bing-Shun W, Thomas J, Van Look P, Wagner M. Rates of caesarean section: analysis of global, regional and national estimates. Paediatr Perinat Epidemiol 2007;21:98-113.","journal-title":"Paediatr Perinat Epidemiol"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1097\/01.SMJ.0000163309.53317.B8","article-title":"Postpartum hemorrhage after cesarean delivery: an analysis of risk factors","volume":"98","author":"Magann","year":"2005","unstructured":"5. Magann EF, Evans S, Hutchinson M, Collins R, Lanneau G, Morrison JC. Postpartum hemorrhage after cesarean delivery: an analysis of risk factors. South Med J 2005;98:681-5.","journal-title":"South Med J"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1034\/j.1600-0412.2001.080003245.x","article-title":"A randomized, controlled trial comparing effect of oral misoprostol and intravenous syntocinon on intra-operative blood loss during cesarean section","volume":"80","author":"Acharya","year":"2001","unstructured":"6. Acharya G, Al-Sammarai MT, Patel N, Al-Habib A, Kiserud T. A randomized, controlled trial comparing effect of oral misoprostol and intravenous syntocinon on intra-operative blood loss during cesarean section. Acta Obstet Gynecol Scand 2001;80:245-50.","journal-title":"Acta Obstet Gynecol Scand"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"102358","DOI":"10.1016\/j.jogoh.2022.102358","article-title":"Efficacy of oxytocics on reducing intraoperative blood loss during abdominal myomectomy: A systematic review and meta-analysis of randomized placebo-controlled trials","volume":"51","author":"Albazee","year":"2022","unstructured":"7. Albazee E, Sayad R, Elrashedy AA, Samy Z, Faraag E, Baradwan S, Samy A. Efficacy of oxytocics on reducing intraoperative blood loss during abdominal myomectomy: A systematic review and meta-analysis of randomized placebo-controlled trials. J Gynecol Obstet Hum Reprod 2022;51:102358.","journal-title":"J Gynecol Obstet Hum Reprod"},{"key":"ref7","doi-asserted-by":"publisher","unstructured":"8. Conde-Agudelo A, Nieto A, Rosas-Bermudez A, Romero R. Misoprostol to reduce intraoperative and postoperative hemorrhage during cesarean delivery: a systematic review and metaanalysis. Am J Obstet Gynecol 2013;209:40.e1-40.e17.","DOI":"10.1016\/j.ajog.2013.03.015"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1111\/1471-0528.12134","article-title":"Effect of misoprostol versus oxytocin during caesarean section: a systematic review and meta-analysis","volume":"120","author":"Hua","year":"2013","unstructured":"9. Hua J, Chen G, Xing F, Scott M, Li Q. Effect of misoprostol versus oxytocin during caesarean section: a systematic review and meta-analysis. BJOG 2013;120:531-40.","journal-title":"BJOG"},{"key":"ref9","doi-asserted-by":"publisher","unstructured":"10. Khan RU, El-Refaey H. Pharmacokinetics and adverse-effect profile of rectally administered misoprostol in the third stage of labor. Obstet Gynecol 2003;101:968-74.","DOI":"10.1016\/S0029-7844(03)00174-1"},{"key":"ref10","doi-asserted-by":"publisher","unstructured":"11. Cumpston M, Li T, Page MJ, Chandler J, Welch VA, Higgins JP, Thomas J. Updated guidance for trusted systematic reviews: a new edition of the Cochrane Handbook for Systematic Reviews of Interventions. Cochrane Database Syst Rev 2019;10:ED000142.","DOI":"10.1002\/14651858.ED000142"},{"key":"ref11","doi-asserted-by":"publisher","unstructured":"12. Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ 2021;372:n71.","DOI":"10.1136\/bmj.n71"},{"key":"ref12","doi-asserted-by":"publisher","unstructured":"13. Higgins JP, Altman DG, G\u00f8tzsche PC, J\u00fcni P, Moher D, Oxman AD, et al. The Cochrane Collaboration's tool for assessing risk of bias in randomised trials. BMJ 2011;343:d5928.","DOI":"10.1136\/bmj.d5928"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1136\/bmj.315.7109.629","article-title":"Bias in meta-analysis detected by a simple, graphical test","volume":"315","author":"Egger","year":"1997","unstructured":"14. Egger M, Davey Smith G, Schneider M, Minder C. Bias in meta-analysis detected by a simple, graphical test. BMJ 1997;315:629-34.","journal-title":"BMJ"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"34","DOI":"10.3126\/njog.v8i2.9767","article-title":"Comparative study of rectal misoprostol to oxytocin infusion in preventing postpartum haemorrhage after caesarean section","volume":"8","author":"Adanikin","year":"2013","unstructured":"15. Adanikin AI, Orji E, Adanikin PO, Olaniyan O. Comparative study of rectal misoprostol to oxytocin infusion in preventing postpartum haemorrhage after caesarean section. Nepal j obstet gynaecol 2013;8:34-7.","journal-title":"Nepal j obstet gynaecol"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.ijgo.2009.11.009","article-title":"Rectally administered misoprostol versus intravenous oxytocin infusion during cesarean delivery to reduce intraoperative and postoperative blood loss","volume":"109","author":"Chaudhuri","year":"2010","unstructured":"16. Chaudhuri P, Banerjee GB, Mandal A. Rectally administered misoprostol versus intravenous oxytocin infusion during cesarean delivery to reduce intraoperative and postoperative blood loss. Int J Gynaecol Obstet 2010;109:25-9.","journal-title":"Int J Gynaecol Obstet"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"2023","DOI":"10.1111\/jog.12464","article-title":"Rectally administrated misoprostol as an alternative to intravenous oxytocin infusion for preventing post-partum hemorrhage after cesarean delivery","volume":"40","author":"Chaudhuri","year":"2014","unstructured":"17. Chaudhuri P, Mandi S, Mazumdar A. Rectally administrated misoprostol as an alternative to intravenous oxytocin infusion for preventing post-partum hemorrhage after cesarean delivery. J Obstet Gynaecol Res 2014;40:2023-30.","journal-title":"J Obstet Gynaecol Res"},{"key":"ref17","unstructured":"18. Fazel MR, Mansoure-Samimi, Esmaeil-Fakharian. A comparison of rectal misoprostol and intravenous oxytocin on hemorrhage and homeostatic changes during cesarean section. Middle East J Anaesthesiol 2013;22:41-6."},{"key":"ref18","doi-asserted-by":"publisher","first-page":"37","DOI":"10.22146\/jkr.48773","article-title":"Efikasi Misoprostol Rektal Intraoperasi Seksio Cesarea Versus Oksitosin dalam Mengurangi Jumlah Perdarahan untuk Mencegah Perdarahan Post Partum","volume":"6","author":"Milhan","year":"2019","unstructured":"19. Milhan M, Soejoenoes A, Prawitasari S. Efikasi Misoprostol Rektal Intraoperasi Seksio Cesarea Versus Oksitosin dalam Mengurangi Jumlah Perdarahan untuk Mencegah Perdarahan Post Partum. Jurnal Kesehatan Reproduksi 2019;6:37.","journal-title":"Jurnal Kesehatan Reproduksi"},{"key":"ref19","unstructured":"20. Shah M, Urooj H, Shazma Shah, Rahim R. Efficacy of rectal misoprostol vs intravenous oxytocin in preventing postpartum hemorrhage following elective caesarean section. JPMI 2021."},{"key":"ref20","doi-asserted-by":"publisher","unstructured":"21. Ozori ES, Isa I A, Nuvie O, Oweisi P W, Zakaa Z, Ochuko A M, et al. Intraoperative Blood Loss Reduction During Caesarean Delivery- Rectal Misoprostol Versus Oxytocin Infusion- A Randomized Controlled Trial. JBEMi 2022;9.","DOI":"10.14738\/jbemi.94.12760"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"2038","DOI":"10.1111\/jog.15318","article-title":"A systematic review and meta-analysis","volume":"48","author":"Maged","year":"2022","unstructured":"22. Maged AM, Wali AA, Metwally AA, Salah N. The efficacy of misoprostol in reducing intraoperative blood loss in women undergoing elective cesarean section. A systematic review and meta-analysis. J Obstet Gynaecol Res 2022;48:2038-70.","journal-title":"J Obstet Gynaecol Res"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.ijgo.2012.03.038","article-title":"Impact of preoperative rectal misoprostol on blood loss during and after elective cesarean delivery","volume":"118","author":"Elsedeek","year":"2012","unstructured":"23. Elsedeek MS. Impact of preoperative rectal misoprostol on blood loss during and after elective cesarean delivery. Int J Gynaecol Obstet 2012;118:149-52.","journal-title":"Int J Gynaecol Obstet"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1002\/ijgo.12836","article-title":"A systematic review of the cost-effectiveness of uterotonic agents for the prevention of postpartum hemorrhage","volume":"146","author":"Lawrie","year":"2019","unstructured":"24. Lawrie TA, Rogozi\u0144ska E, Sobiesuo P, Vogel JP, Ternent L, Oladapo OT. A systematic review of the cost-effectiveness of uterotonic agents for the prevention of postpartum hemorrhage. Int J Gynaecol Obstet 2019;146:56-64.","journal-title":"Int J Gynaecol Obstet"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"644","DOI":"10.1111\/j.1471-0528.1972.tb14215.x","article-title":"The circulating levels of oxytocin following intravenous and intramuscular administration of Syntometrine","volume":"79","author":"Gibbens","year":"1972","unstructured":"25. Gibbens D, Boyd NR, Crocker S, Baumber S, Chard T. The circulating levels of oxytocin following intravenous and intramuscular administration of Syntometrine. J Obstet Gynaecol Br Commonw 1972;79:644-6.","journal-title":"J Obstet Gynaecol Br Commonw"},{"key":"ref25","doi-asserted-by":"publisher","unstructured":"26. Albazee E, Sadan M, Alenezi AM, Almutairi AN, Alenezi MM, Almonayea LE. Efficacy and Safety of Carbetocin Versus Misoprostol in Cesarean Section: A Systematic Review and Meta-Analysis. Cureus 2022;14:e32901.","DOI":"10.7759\/cureus.32901"},{"key":"ref26","doi-asserted-by":"publisher","unstructured":"27. Albazee E, Alrashidi H, Laqwer R, Elmokid SR, Alghamdi WA, Almahmood H, et al. Intravenous Carbetocin Versus Rectal Misoprostol for the Active Management of the Third Stage of Labor: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Cureus 2022;14:e30229.","DOI":"10.7759\/cureus.30229"}],"container-title":["Journal of Turkish Society of Obstetric and Gynecology"],"original-title":[],"deposited":{"date-parts":[[2024,6,6]],"date-time":"2024-06-06T13:09:31Z","timestamp":1717679371000},"score":1,"resource":{"primary":{"URL":"https:\/\/tjoddergisi.org\/articles\/doi\/tjod.galenos.2023.15098"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,1]]},"references-count":27,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2023,6,1]]},"published-print":{"date-parts":[[2023,6,1]]}},"URL":"https:\/\/doi.org\/10.4274\/tjod.galenos.2023.15098","relation":{},"ISSN":["1307-699X","2149-9330"],"issn-type":[{"value":"1307-699X","type":"print"},{"value":"2149-9330","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,1]]}}}