{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T02:51:19Z","timestamp":1786675879221,"version":"build-2736575974"},"reference-count":26,"publisher":"Galenos Yayinevi","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["tjod"],"DOI":"10.4274\/tjod.galenos.2024.80439","type":"journal-article","created":{"date-parts":[[2024,9,4]],"date-time":"2024-09-04T06:58:29Z","timestamp":1725433109000},"page":"135-141","source":"Crossref","is-referenced-by-count":1,"title":["Might retrigger with human chorionic gonadotropin be a solution for empty follicle syndrome after gonadotropin releasing hormone agonist trigger?"],"prefix":"10.4274","author":[{"given":"Zeynep Ece","family":"Utkan Korun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ay\u015fen","family":"Y\u00fccet\u00fcrk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d6zge","family":"Karaosmano\u011flu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi\u011fit","family":"\u00c7ak\u0131ro\u011flu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00fclent","family":"T\u0131ra\u015f","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2811","published-online":{"date-parts":[[2024,9,4]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"1. Orvieto R. Triggering final follicular maturation: hCG, GnRH-agonist, or both, when and to whom? J Assist Reprod Genet. 2017;34:1231-2.","DOI":"10.1007\/s10815-017-0982-7"},{"key":"ref1","doi-asserted-by":"publisher","first-page":"1051","DOI":"10.1016\/S0015-0282(03)00173-0","article-title":"Use of recombinant human chorionic gonadotropin in ovulation induction","volume":"79","author":"Ludwig","year":"2003","unstructured":"2. Ludwig M, Doody KJ, Doody KM. Use of recombinant human chorionic gonadotropin in ovulation induction. Fertil Steril. 2003;79:1051-9.","journal-title":"Fertil Steril"},{"key":"ref2","doi-asserted-by":"publisher","unstructured":"3. Orvieto R. Can we eliminate severe ovarian hyperstimulation syndrome? Human Reprod. 2005;20:320-2.","DOI":"10.1093\/humrep\/deh613"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1351","DOI":"10.1093\/humrep\/des049","article-title":"Circulating luteinizing hormone level after triggering oocyte maturation with GnRH agonist may predict oocyte yield in flexible GnRH antagonist protocol","volume":"27","author":"Chen","year":"2012","unstructured":"4. Chen SL, Ye DS, Chen X, Yang XH, Zheng HY, Tang Y, et al. Circulating luteinizing hormone level after triggering oocyte maturation with GnRH agonist may predict oocyte yield in flexible GnRH antagonist protocol. Human Reprod. 2012;27:1351-6.","journal-title":"Human Reprod"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"1356","DOI":"10.1016\/j.fertnstert.2016.07.1068","article-title":"Dual trigger for final oocyte maturation improves the oocyte retrieval rate of suboptimal responders to gonadotropin-releasing hormone agonist","volume":"106","author":"Lu","year":"2016","unstructured":"5. Lu X, Hong Q, Sun L, Chen Q, Fu Y, Ai A, et al. Dual trigger for final oocyte maturation improves the oocyte retrieval rate of suboptimal responders to gonadotropin-releasing hormone agonist. Fertil Steril. 2016;106:1356-62.","journal-title":"Fertil Steril"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.fertnstert.2003.05.032","article-title":"Luteolysis induced by a gonadotropin-releasing hormone agonist is the key to prevention of ovarian hyperstimulation syndrome","volume":"81","author":"Kol","year":"2004","unstructured":"6. Kol S. Luteolysis induced by a gonadotropin-releasing hormone agonist is the key to prevention of ovarian hyperstimulation syndrome. Fertil Steril. 2004;81:1-5.","journal-title":"Fertil Steril"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1016\/j.ejogrb.2011.03.002","article-title":"Failure of triggering oocyte maturation with a GnRH agonist in polycystic ovary syndrome: two case reports","volume":"157","author":"Honnma","year":"2011","unstructured":"7. Honnma H, Hashiba Y, Asada Y, Endo T. Failure of triggering oocyte maturation with a GnRH agonist in polycystic ovary syndrome: two case reports. Eur J Obstet Gynecol Reprod Biol. 2011;157:239-40.","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1007\/s10815-011-9704-8","article-title":"Empty follicle syndrome after GnRHa triggering versus hCG triggering in COS","volume":"29","author":"Castillo","year":"2012","unstructured":"8. Castillo JC, Garcia-Velasco J, Humaidan P. Empty follicle syndrome after GnRHa triggering versus hCG triggering in COS. J Assist Reprod Genet. 2012;29:249-53.","journal-title":"J Assist Reprod Genet"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1007\/s10815-013-9966-4","article-title":"Failure of GnRH agonist-triggered oocyte maturation: its cause and management","volume":"30","author":"Asada","year":"2013","unstructured":"9. Asada Y, Itoi F, Honnma H, Takiguchi S, Fukunaga N, Hashiba Y, et al. Failure of GnRH agonist-triggered oocyte maturation: its cause and management. J Assist Reprod Genet. 2013;30:581-5.","journal-title":"J Assist Reprod Genet"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"248","DOI":"10.3109\/14647273.2015.1071500","article-title":"Rescue hCG to treat empty follicle syndrome after the use of a GnRH agonist as oocyte maturation trigger: first report on fresh embryo transfer and clinical pregnancy","volume":"18","author":"Christopoulos","year":"2015","unstructured":"10. Christopoulos G, Vlismas A, Barsoum-Derias E, El-Shawarby S, Trew G, Lavery S. Rescue hCG to treat empty follicle syndrome after the use of a GnRH agonist as oocyte maturation trigger: first report on fresh embryo transfer and clinical pregnancy. Hum Fertil. 2015;18:248-52.","journal-title":"Hum Fertil"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"764299","DOI":"10.3389\/frph.2021.764299","article-title":"HCG trigger after failed GnRH agonist trigger resulted in two consecutive live births: A case report","volume":"3","author":"Liest","year":"2021","unstructured":"11. Liest S, Riishede Christiansen I, Pr\u00e6torius L, Bogstad J, Freiesleben N la C, Pinborg A, et al. HCG trigger after failed GnRH agonist trigger resulted in two consecutive live births: A case report. Front Reprod Health. 2021;3:764299.","journal-title":"Front Reprod Health"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1016\/S0015-0282(16)54124-7","article-title":"Failure of oocyte retrieval during in vitro fertilization: a sporadic event rather than a syndrome","volume":"55","author":"Ben-Shlomo","year":"1991","unstructured":"12. Ben-Shlomo I, Schiff E, Levran D, Ben-Rafael Z, Mashiach S, Dor J. Failure of oocyte retrieval during in vitro fertilization: a sporadic event rather than a syndrome. Fertil Steril. 1991;55:324-7.","journal-title":"Fertil Steril"},{"key":"ref12","doi-asserted-by":"publisher","unstructured":"13. Awonuga A, Govindbhai J, Zierke S, Schnauffer K. Continuing the debate on empty follicle syndrome: can it be associated with normal bioavailability of beta-human chorionic gonadotrophin on the day of oocyte recovery? Hum Reprod. 1998;13:1281-4.","DOI":"10.1093\/humrep\/13.5.1281"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"999","DOI":"10.1093\/humrep\/15.5.999","article-title":"Empty follicle syndrome: evidence for recurrence","volume":"15","author":"Zreik","year":"2000","unstructured":"14. Zreik TG, Garcia-Velasco JA, Vergara TM, Arici A, Olive D, Jones EE. Empty follicle syndrome: evidence for recurrence. Human Reprod. 2000;15:999-1002.","journal-title":"Human Reprod"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"2262","DOI":"10.1093\/oxfordjournals.humrep.a136281","article-title":"Endocrinology: The empty follicle syndrome: a pharmaceutical industry syndrome","volume":"10","author":"Zegers-Hochschild","year":"1995","unstructured":"15. Zegers-Hochschild F, Fernandez E, Mackenna A, Fabres C, Altieri E, Lopez T. Endocrinology: The empty follicle syndrome: a pharmaceutical industry syndrome. Human Reprod. 1995;10:2262-5.","journal-title":"Human Reprod"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1097\/GCO.0000000000000701","article-title":"Suboptimal response to GnRH agonist trigger: causes and practical management","volume":"33","author":"Humaidan","year":"2021","unstructured":"16. Humaidan P, Kol S. Suboptimal response to GnRH agonist trigger: causes and practical management. Curr Opin Obstet Gynecol. 2021;33:213-7.","journal-title":"Curr Opin Obstet Gynecol"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1016\/j.fertnstert.2007.07.1312","article-title":"Empty follicle syndrome: the reality of a controversial syndrome, a systematic review","volume":"90","author":"TL","year":"2008","unstructured":"17. Stevenson TL, Lashen H. Empty follicle syndrome: the reality of a controversial syndrome, a systematic review. Fertil Steril. 2008;90:691-8.","journal-title":"Fertil Steril"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"792","DOI":"10.1210\/jcem-57-4-792","article-title":"Hormonal dynamics at midcycle: a reevaluation","volume":"57","author":"Hoff","year":"1983","unstructured":"18. Hoff JD, Quigley ME, Yen SSC. Hormonal dynamics at midcycle: a reevaluation. J Clin Endocrinol Metab. 1983;57:792-6.","journal-title":"J Clin Endocrinol Metab"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/S0015-0282(16)54474-4","article-title":"Induction of preovulatory luteinizing hormone surge and prevention of ovarian hyperstimulation syndrome by gonadotropin-releasing hormone agonist","volume":"56","author":"Itskovitz","year":"1991","unstructured":"19. Itskovitz J, Boldes R, Levron J, Erlik Y, Kahana L, Brandes JM. Induction of preovulatory luteinizing hormone surge and prevention of ovarian hyperstimulation syndrome by gonadotropin-releasing hormone agonist. Fertil Steril. 1991;56:213-20.","journal-title":"Fertil Steril"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1016\/S0015-0282(16)60906-8","article-title":"Disappearance of exogenously administered human chorionic gonadotropin","volume":"52","author":"Damewood","year":"1989","unstructured":"20. Damewood MD, Shen W, Zacur HA, Schlaff WD, Rock JA, Wallach EE. Disappearance of exogenously administered human chorionic gonadotropin. Fertil Steril. 1989;52:398-400.","journal-title":"Fertil Steril"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"273","DOI":"10.3109\/09513599609012319","article-title":"Human chorionic gonadotropin: pharmacokinetics of subcutaneous administration","volume":"10","author":"Weissinan","year":"1996","unstructured":"21. Weissinan A, Lurie S, Zalel Y, Goldchmit R, Shoham Z. Human chorionic gonadotropin: pharmacokinetics of subcutaneous administration. Gynecol Endocrinol. 1996;10:273-6.","journal-title":"Gynecol Endocrinol"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"1093","DOI":"10.1016\/j.fertnstert.2016.06.013","article-title":"Assessing the adequacy of gonadotropin-releasing hormone agonist leuprolide to trigger oocyte maturation and management of inadequate response","volume":"106","author":"Chang","year":"2016","unstructured":"22. Chang FE, Beall SA, Cox JM, Richter KS, DeCherney AH, Levy MJ. Assessing the adequacy of gonadotropin-releasing hormone agonist leuprolide to trigger oocyte maturation and management of inadequate response. Fertil Steril. 2016;106:1093-100.","journal-title":"Fertil Steril"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1002\/rmb2.12359","article-title":"Gonadotropin levels at the start of ovarian stimulation predict normal fertilization after hCG re\u2010trigger in GnRH antagonist cycles","volume":"20","author":"Kitasaka","year":"2021","unstructured":"23. Kitasaka H, Tokoro M, Kojima M, Fukunaga N, Asada Y. Gonadotropin levels at the start of ovarian stimulation predict normal fertilization after hCG re\u2010trigger in GnRH antagonist cycles. Reprod Med Biol. 2021;20:96-107.","journal-title":"Reprod Med Biol"},{"key":"ref23","unstructured":"24. Deepika K, Sindhuma D, Kiran B, Ravishankar N, Gautham P, Kamini R. Empty follicle syndrome following GnRHa trigger in PCOS patients undergoing IVF cycles. J Reprod Infertil. 2018;19:16."},{"key":"ref24","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1210\/jcem.87.2.8197","article-title":"Endocrine profiles after triggering of final oocyte maturation with GnRH agonist after cotreatment with the GnRH antagonist ganirelix during ovarian hyperstimulation for in vitro fertilization","volume":"87","author":"Fauser","year":"2002","unstructured":"25. Fauser BC, de Jong D, Olivennes F, Wramsby H, Tay C, Itskovitz-Eldor J, et al. Endocrine profiles after triggering of final oocyte maturation with GnRH agonist after cotreatment with the GnRH antagonist ganirelix during ovarian hyperstimulation for in vitro fertilization. J Clin Endocrinol Metab. 2002;87:709-15.","journal-title":"J Clin Endocrinol Metab"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1093\/humrep\/des361","article-title":"Predicting successful induction of oocyte maturation after gonadotropin-releasing hormone agonist (GnRHa) trigger","volume":"28","author":"Kummer","year":"2013","unstructured":"26. Kummer NE, Feinn RS, Griffin DW, Nulsen JC, Benadiva CA, Engmann LL. Predicting successful induction of oocyte maturation after gonadotropin-releasing hormone agonist (GnRHa) trigger. Human Reprod. 2013;28:152-9.","journal-title":"Human Reprod"}],"container-title":["Journal of Turkish Society of Obstetric and Gynecology"],"original-title":[],"deposited":{"date-parts":[[2024,9,13]],"date-time":"2024-09-13T06:42:30Z","timestamp":1726209750000},"score":1,"resource":{"primary":{"URL":"https:\/\/tjoddergisi.org\/articles\/might-retrigger-with-human-chorionic-gonadotropin-be-a-solution-for-empty-follicle-syndrome-after-gonadotropin-releasing-hormone-agonist-trigger\/doi\/tjod.galenos.2024.80439"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,4]]},"references-count":26,"URL":"https:\/\/doi.org\/10.4274\/tjod.galenos.2024.80439","relation":{},"ISSN":["1307-699X","2149-9330"],"issn-type":[{"value":"1307-699X","type":"print"},{"value":"2149-9330","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,4]]}}}