{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T18:47:44Z","timestamp":1791917264278,"version":"4.3.4"},"reference-count":25,"publisher":"Galenos Yayinevi","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["tjtcs"],"DOI":"10.4274\/tjtcs.2025.26780","type":"journal-article","created":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T06:39:50Z","timestamp":1767940790000},"page":"12-18","source":"Crossref","is-referenced-by-count":1,"title":["Polymorphisms of the MMP2 and MMP9 genes in the development of aortic aneurysm in patients with bicuspid aortic valve"],"prefix":"10.4274","volume":"34","author":[{"given":"\u0130hsan","family":"Alur","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali Baran","family":"Budak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emre","family":"K\u00fclah\u00e7\u0131o\u011flu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmet Deniz","family":"Kaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tevfik","family":"G\u00fcne\u015f","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yavuz","family":"Dodurga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0130brahim","family":"G\u00f6k\u015fin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2811","published-online":{"date-parts":[[2026,1,9]]},"reference":[{"key":"ref0","unstructured":"1. Wedin J, Vedin O, St\u00e5hle E, Grinnemo KH. Bikuspid aortaklaff - vanligaste medf\u00f6dda hj\u00e4rtmissbildningen - Folksjukdom med allvarliga l\u00e5ngtidskomplikationer, samlat konsensusdokument ger nu rekommendationer [Bicuspid aortic valve - a common congenital cardiac malformation associated with serious complications]. Lakartidningen. 2019;116:FHWP. Swedish."},{"key":"ref1","doi-asserted-by":"publisher","unstructured":"2. LeMaire SA, Wang X, Wilks JA, Carter SA, Wen S, Won T, et al. Matrix metalloproteinases in ascending aortic aneurysms: bicuspid versus trileaflet aortic valves. J Surg Res. 2005;123:40-8. doi: 10.1016\/j.jss.2004.06.007.","DOI":"10.1016\/j.jss.2004.06.007"},{"key":"ref2","unstructured":"3. Alur \u0130, Tetik A, Dodurga Y, G\u00fcne\u015f T, G\u00f6k\u015fin \u0130. Literature-based evaluation of matrix metalloproteinase gene polymorphisms in patients with the bicuspid aortic valve and ascending aortic aneurysm patients. Izm Univ Med J. 2015;2:17-21."},{"key":"ref3","doi-asserted-by":"publisher","unstructured":"4. Nagase H, Visse R, Murphy G. Structure and function of matrix metalloproteinases and TIMPs. Cardiovasc Res. 2006;69:562-73. doi: 10.1016\/j.cardiores.2005.12.002.","DOI":"10.1016\/j.cardiores.2005.12.002"},{"key":"ref4","doi-asserted-by":"publisher","unstructured":"5. Sattari M, Hassanzad M, Jamaldini SH, Najafi A, Imani M, Mohammadhassani M, et al. Association between matrix metaloproteinases 2-1306C\/T polymorphism and the risk of coronary artery disease in Iranian population. Pathophysiology. 2017;24:185-9. doi: 10.1016\/j.pathophys.2017.05.001.","DOI":"10.1016\/j.pathophys.2017.05.001"},{"key":"ref5","doi-asserted-by":"publisher","unstructured":"6. Mizon-G\u00e9rard F, de Groote P, Lamblin N, Hermant X, Dallongeville J, Amouyel P, et al. Prognostic impact of matrix metalloproteinase gene polymorphisms in patients with heart failure according to the aetiology of left ventricular systolic dysfunction. Eur Heart J. 2004;25:688-93. doi: 10.1016\/j.ehj.2004.01.015.","DOI":"10.1016\/j.ehj.2004.01.015"},{"key":"ref6","doi-asserted-by":"publisher","unstructured":"7. Kose T, Antal A, Gunel T. Expression of MMP2, MMP9, TIMP2 and TIMP3 genes in aortic dissection. Exp Ther Med. 2024;28:360. doi: 10.3892\/etm.2024.12649.","DOI":"10.3892\/etm.2024.12649"},{"key":"ref7","doi-asserted-by":"publisher","unstructured":"8. Nataatmadja M, West M, West J, Summers K, Walker P, Nagata M, et al. Abnormal extracellular matrix protein transport associated with increased apoptosis of vascular smooth muscle cells in marfan syndrome and bicuspid aortic valve thoracic aortic aneurysm. Circulation. 2003 108(Suppl 1):II329-34. doi: 10.1161\/01.cir.0000087660.82721.15.","DOI":"10.1161\/01.cir.0000087660.82721.15"},{"key":"ref8","doi-asserted-by":"publisher","unstructured":"9. Bilgen F. Ascending aorta replacement in bicuspid aortic valve: when?. Turk J Thorac Cardiovasc Surg. 2011;19. doi: 10.5606\/tgkdc.dergisi.2011.03Suppl2.","DOI":"10.5606\/tgkdc.dergisi.2011.03Suppl2"},{"key":"ref9","doi-asserted-by":"publisher","unstructured":"10. Ashworth JL, Murphy G, Rock MJ, Sherratt MJ, Shapiro SD, Shuttleworth CA, et al. Fibrillin degradation by matrix metalloproteinases: implications for connective tissue remodelling. Biochem J. 1999;340(Pt 1)(Pt 1):171-81.","DOI":"10.1042\/bj3400171"},{"key":"ref10","doi-asserted-by":"publisher","unstructured":"11. Jackson ZS, Gotlieb AI, Langille BL. Wall tissue remodeling regulates longitudinal tension in arteries. Circ Res. 2002;90:918-25. doi: 10.1161\/01.res.0000016481.87703.cc.","DOI":"10.1161\/01.RES.0000016481.87703.CC"},{"key":"ref11","doi-asserted-by":"publisher","unstructured":"12. Magid R, Murphy TJ, Galis ZS. Expression of matrix metalloproteinase-9 in endothelial cells is differentially regulated by shear stress. Role of c-Myc. J Biol Chem. 2003;278:32994-9. doi: 10.1074\/jbc.M304799200.","DOI":"10.1074\/jbc.M304799200"},{"key":"ref12","doi-asserted-by":"publisher","unstructured":"13. Golledge J. Abdominal aortic aneurysm: update on pathogenesis and medical treatments. Nat Rev Cardiol. 2019;16:225-42. doi: 10.1038\/s41569-018-0114-9.","DOI":"10.1038\/s41569-018-0114-9"},{"key":"ref13","doi-asserted-by":"publisher","unstructured":"14. Choke E, Cockerill GW, Dawson J, Wilson RW, Jones A, Loftus IM, et al. Increased angiogenesis at the site of abdominal aortic aneurysm rupture. Ann N Y Acad Sci. 2006;1085:315-9. doi: 10.1196\/annals.1383.007.","DOI":"10.1196\/annals.1383.007"},{"key":"ref14","doi-asserted-by":"publisher","unstructured":"15. Cho MJ, Lee MR, Park JG. Aortic aneurysms: current pathogenesis and therapeutic targets. Exp Mol Med. 2023;55:2519-30. doi: 10.1038\/s12276-023-01130-w.","DOI":"10.1038\/s12276-023-01130-w"},{"key":"ref15","doi-asserted-by":"publisher","unstructured":"16. Castro MM, Rizzi E, Prado CM, Rossi MA, Tanus-Santos JE, Gerlach RF. Imbalance between matrix metalloproteinases and tissue inhibitor of metalloproteinases in hypertensive vascular remodeling. Matrix Biol. 2010;29:194-201. doi: 10.1016\/j.matbio.2009.11.005.","DOI":"10.1016\/j.matbio.2009.11.005"},{"key":"ref16","doi-asserted-by":"publisher","unstructured":"17. Fedak PW, de Sa MP, Verma S, Nili N, Kazemian P, Butany J, et al. Vascular matrix remodeling in patients with bicuspid aortic valve malformations: implications for aortic dilatation. J Thorac Cardiovasc Surg. 2003;126:797-806. doi: 10.1016\/s0022-5223(03)00398-2.","DOI":"10.1016\/S0022-5223(03)00398-2"},{"key":"ref17","doi-asserted-by":"publisher","unstructured":"18. Boyum J, Fellinger EK, Schmoker JD, Trombley L, McPartland K, Ittleman FP, et al. Matrix metalloproteinase activity in thoracic aortic aneurysms associated with bicuspid and tricuspid aortic valves. J Thorac Cardiovasc Surg. 2004;127:686-91. doi: 10.1016\/j.jtcvs.2003.11.049.","DOI":"10.1016\/j.jtcvs.2003.11.049"},{"key":"ref18","doi-asserted-by":"publisher","unstructured":"19. Phillippi JA, Green BR, Eskay MA, Kotlarczyk MP, Hill MR, Robertson AM, et al. Mechanism of aortic medial matrix remodeling is distinct in patients with bicuspid aortic valve. J Thorac Cardiovasc Surg. 2014;147:1056-64. doi: 10.1016\/j.jtcvs.2013.04.028.","DOI":"10.1016\/j.jtcvs.2013.04.028"},{"key":"ref19","doi-asserted-by":"publisher","unstructured":"20. Wang Y, Wu B, Dong L, Wang C, Wang X, Shu X. Circulating matrix metalloproteinase patterns in association with aortic dilatation in bicuspid aortic valve patients with isolated severe aortic stenosis. Heart Vessels. 2016;31:189-97. doi: 10.1007\/s00380-014-0593-5.","DOI":"10.1007\/s00380-014-0593-5"},{"key":"ref20","doi-asserted-by":"publisher","unstructured":"21. Abaci O, Kocas C, Kilickesmez KO, Uner S, Kucukoglu S. Matrix metalloproteinase-2 and -9 levels in patients with dilated ascending aorta and bicuspid aortic valve. Echocardiography. 2013;30:121-6. doi: 10.1111\/echo.12004.","DOI":"10.1111\/echo.12004"},{"key":"ref21","doi-asserted-by":"publisher","unstructured":"22. Rabkin SW. Differential expression of MMP-2, MMP-9 and TIMP proteins in thoracic aortic aneurysm - comparison with and without bicuspid aortic valve: a meta-analysis. Vasa. 2014;43:433-42. doi: 10.1024\/0301-1526\/a000390.","DOI":"10.1024\/0301-1526\/a000390"},{"key":"ref22","doi-asserted-by":"publisher","unstructured":"23. Li T, Jiang B, Li X, Sun HY, Li XT, Jing JJ, et al. Serum matrix metalloproteinase-9 is a valuable biomarker for identification of abdominal and thoracic aortic aneurysm: a case-control study. BMC Cardiovasc Disord. 2018;18:202. doi: 10.1186\/s12872-018-0931-0.","DOI":"10.1186\/s12872-018-0931-0"},{"key":"ref23","doi-asserted-by":"publisher","unstructured":"24. Freestone T, Turner RJ, Coady A, Higman DJ, Greenhalgh RM, Powell JT. Inflammation and matrix metalloproteinases in the enlarging abdominal aortic aneurysm. Arterioscler Thromb Vasc Biol. 1995;15:1145-51. doi: 10.1161\/01.atv.15.8.1145.","DOI":"10.1161\/01.ATV.15.8.1145"},{"key":"ref24","doi-asserted-by":"publisher","unstructured":"25. McMillan WD, Tamarina NA, Cipollone M, Johnson DA, Parker MA, Pearce WH. Size matters: the relationship between MMP-9 expression and aortic diameter. Circulation. 1997;96:2228-32. doi: 10.1161\/01.cir.96.7.2228.","DOI":"10.1161\/01.CIR.96.7.2228"}],"container-title":["Turkish Journal of Thoracic and Cardiovascular Surgery"],"original-title":[],"deposited":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T13:53:00Z","timestamp":1782222780000},"score":1,"resource":{"primary":{"URL":"https:\/\/tjtcvs.org\/articles\/polymorphisms-of-the-lessemgreatermmp2lessemgreater-and-lessemgreatermmp9lessemgreater-genes-in-the-development-of-aortic-aneurysm-in-patients-with-bicuspid-aortic-valve\/doi\/tjtcs.2025.26780"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,9]]},"references-count":25,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,1,9]]}},"URL":"https:\/\/doi.org\/10.4274\/tjtcs.2025.26780","relation":{},"ISSN":["1301-5680","1301-5680"],"issn-type":[{"value":"1301-5680","type":"print"},{"value":"1301-5680","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,9]]}}}