{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T02:07:30Z","timestamp":1788833250871,"version":"build-2803163510"},"reference-count":52,"publisher":"Baishideng Publishing Group Inc.","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World J Gastrointest Pathophysiol"],"abstract":"<jats:p>Carbohydrate antigen 72-4 (CA72-4) is a serum tumor marker linked to tumor-associated glycoprotein 72 (TAG-72), a high-molecular-weight mucin-like antigen identified during the monoclonal-antibody era. Although developed later than CA19-9 and most closely associated with gastric cancer, CA72-4 has since attracted broader interest across gastrointestinal oncology, peritoneal disease, malignant effusions, cytology, benign false-positive states and TAG-72-directed translational research. This review examines the history, biology, clinical utility, diagnostic limitations and future applications of CA72-4 and TAG-72, using gastric cancer as the principal clinical anchor while considering wider esophagogastric, colorectal, appendiceal, pancreaticobiliary, peritoneal and fluid-based applications. Current evidence supports CA72-4 as an adjunctive biomarker rather than a population screening test or stand-alone diagnostic tool. Its most defensible clinical roles are in gastric cancer risk stratification, peritoneal disease assessment, selected multimarker panels and malignant effusion work-up. Looking ahead, TAG-72 may ultimately prove more clinically consequential than serum CA72-4 itself if imaging, cytology-based diagnostics and targeted therapeutic platforms continue to mature.<\/jats:p>","DOI":"10.4291\/wjgp.125464","type":"journal-article","created":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T08:45:38Z","timestamp":1788252338000},"source":"Crossref","is-referenced-by-count":0,"title":["Carbohydrate antigen 72-4 and tumor-associated glycoprotein 72 - tumor marker: Past, present and future"],"prefix":"10.4291","volume":"17","author":[{"given":"Rui-Kyi","family":"Ng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vishal G","family":"Shelat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2060","published-online":{"date-parts":[[2026,9,22]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.4240\/wjgs.v12.i12.468"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3982"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1251"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.78.5.3199"},{"key":"B5","unstructured":"Johnson VG, Schlom J, Paterson AJ, Bennett J, Magnani JL, Colcher D. 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