{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T04:53:37Z","timestamp":1784091217712,"version":"3.55.0"},"reference-count":149,"publisher":"Baishideng Publishing Group Inc.","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["WJGP"],"published-print":{"date-parts":[[2021,9,22]]},"DOI":"10.4291\/wjgp.v12.i5.84","type":"journal-article","created":{"date-parts":[[2021,9,15]],"date-time":"2021-09-15T03:35:41Z","timestamp":1631676941000},"page":"84-105","source":"Crossref","is-referenced-by-count":12,"title":["Cholangiocarcinoma and liver transplantation: What we know so far?"],"prefix":"10.4291","volume":"12","author":[{"given":"Ali Reza","family":"Safarpour","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hassan","family":"Askari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farshid","family":"Ejtehadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asaad","family":"Azarnezhad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ehsan","family":"Raeis-Abdollahi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir","family":"Tajbakhsh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Foad","family":"Abazari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Firoozeh","family":"Tarkesh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alireza","family":"Shamsaeefar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramin","family":"Niknam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gholam Reza","family":"Sivandzadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamran Bagheri","family":"Lankarani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fardad","family":"Ejtehadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2060","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2013.10.013"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2015-0446"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpg.2011.10.002"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26565"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1080\/003655202760373434"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0b013e3283554bbf"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djj234"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000179678.13285.fa"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-200110000-00010"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.08.046"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1002\/lt.24955"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpg.2015.02.006"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/j.path.2018.02.005"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1097\/MOG.0000000000000611"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.4254\/wjh.v2.i12.419"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2016.51"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1111\/liv.14093"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1002\/hep.25587"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3375"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-17-0245"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2011-0386"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-020-0310-z"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-17-0368"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2013.01.001"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1111\/liv.14102"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.010561"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1055\/s-0034-1394144"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1002\/jhbp.66"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.02.033"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2012.617"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28431"},{"key":"B32","doi-asserted-by":"crossref","unstructured":"Isomoto H. Epigenetic alterations associated with cholangiocarcinoma (review). Oncol Rep 2009; 22: 227-232","DOI":"10.3892\/or_00000428"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.2007.01624.x"},{"key":"B34","unstructured":"Limpaiboon T. Epigenetic aberrations in cholangiocarcinoma: potential biomarkers and promising target for novel therapeutic strategies. Asian Pac J Cancer Prev 2012; 13 Suppl: 41-45"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2017.06.014"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.7150\/jca.21785"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2016.03.010"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.15721"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1097\/MOG.0000000000000333"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-006-9681-4"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1016\/s0168-8278(01)00288-4"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-020-01663-1"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2017.02.038"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.3109\/00365521.2015.1036359"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2012.09.009"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24351"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2001.25087"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2011.11.015"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2011-301748"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.28312"},{"key":"B51","doi-asserted-by":"crossref","unstructured":"Shaib Y, El-Serag HB.   The epidemiology of cholangiocarcinoma. Proceedings of the Seminars in liver disease; 2004. New York: Thieme Medical Publishers, 2004: 115-125","DOI":"10.1055\/s-2004-828889"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2012.02.022"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1016\/j.suc.2010.04.011"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2013.05.021"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2003.11.030"},{"key":"B56","unstructured":"Mouzas IA, Dimoulios P, Vlachonikolis IG, Skordilis P, Zoras O, Kouroumalis E. Increasing incidence of cholangiocarcinoma in Crete 1992-2000. Anticancer Res 2002; 22: 3637-3641"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1055\/s-2004-828889"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.2006.01350.x"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2004.12.048"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-008-9933-y"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)61903-0"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1007\/s005340070002"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.3978\/j.issn.2078-6891.2015.117"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-200004270-00019"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2012.04.008"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000108702.45715.81"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1016\/s0002-9610(05)80696-8"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1002\/lt.22307"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1097\/MOG.0b013e32835d9dea"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2019.11.020"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1007\/s11605-007-0335-4"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199603143341104"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v18.i1.1"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1007\/s11605-020-04721-4"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1002\/lt.24975"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2020.12244"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1097\/01.tp.0000253551.43583.d1"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1111\/hpb.12082"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2015.01.064"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.6618"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1111\/hpb.12450"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000002574"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000002716"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2019.12.037"},{"key":"B85","unstructured":"Edge SB, Byrd DR, Carducci MA, Compton CC, Fritz A, Greene F. AJCC cancer staging manual.  New York: Springer, 2010"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1055\/s-2004-828896"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-020-09001-8"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.1159\/000324688"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.1159\/000212990"},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2019.06.007"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.1002\/jso.10024"},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.1097\/00008469-200506000-00008"},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21964"},{"key":"B94","unstructured":"Ko KH, Kim NK, Yim DJ, Hong SP, Park PW, Rim KS, Kim S, Hwang SG. Polymorphisms of 5,10-methylenetetrahydrofolate reductase (MTHFR C677T) and thymidylate synthase enhancer region (TSER) as a risk factor of cholangiocarcinoma in a Korean population. Anticancer Res 2006; 26: 4229-4233"},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgi314"},{"key":"B96","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgm247"},{"key":"B97","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2005.05.020"},{"key":"B98","unstructured":"Gong Y, Qi M, Chen J, Fang R, Mai C, Chen T, Tang H, Tang Y. XRCC1 Arg194Trp and Arg399Gln polymorphisms and risk of extrahepatic cholangiocarcinoma: a hospital-based case-control study in China. Int J Clin Exp Med 2015; 8: 19339-19345"},{"key":"B99","unstructured":"Kang YK, Kim WH, Lee HW, Lee HK, Kim YI. Mutation of p53 and K-ras, and loss of heterozygosity of APC in intrahepatic cholangiocarcinoma. Lab Invest 1999; 79: 477-483"},{"key":"B100","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgz179"},{"key":"B101","doi-asserted-by":"publisher","DOI":"10.3109\/07357900903095714"},{"key":"B102","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2020.01292"},{"key":"B103","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2013-0352"},{"key":"B104","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-11-3596"},{"key":"B105","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00296.2019"},{"key":"B106","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-020-06804-6"},{"key":"B107","doi-asserted-by":"publisher","DOI":"10.1136\/gut.47.5.721"},{"key":"B108","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2019.10904"},{"key":"B109","doi-asserted-by":"publisher","DOI":"10.1111\/his.13234"},{"key":"B110","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2010.06.009"},{"key":"B111","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-014-3828-x"},{"key":"B112","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-20-2769"},{"key":"B113","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v11.i9.1333"},{"key":"B114","doi-asserted-by":"publisher","DOI":"10.1097\/MOG.0b013e3283523c7e"},{"key":"B115","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.ccr-1137-3"},{"key":"B116","doi-asserted-by":"publisher","DOI":"10.5858\/2007-131-923-MPOMCI"},{"key":"B117","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3800287"},{"key":"B118","unstructured":"Liu XF, Zhu SG, Zhang H, Xu Z, Su HL, Li SJ, Zhou XT. The methylation status of the TMS1\/ASC gene in cholangiocarcinoma and its clinical significance. Hepatobiliary Pancreat Dis Int 2006; 5: 449-453"},{"key":"B119","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.2005.01174.x"},{"key":"B120","doi-asserted-by":"publisher","DOI":"10.1016\/s0168-8278(02)00269-6"},{"key":"B121","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64262-9"},{"key":"B122","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2004.tb03254.x"},{"key":"B123","doi-asserted-by":"publisher","DOI":"10.1245\/ASO.2005.07.020"},{"key":"B124","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.20944"},{"key":"B125","doi-asserted-by":"publisher","DOI":"10.3892\/etm_00000060"},{"key":"B126","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2011.102"},{"key":"B127","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2012.03.045"},{"key":"B128","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2016.10.021"},{"key":"B129","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v13.i48.6465"},{"key":"B130","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23381"},{"key":"B131","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2012.06.049"},{"key":"B132","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2006.02.057"},{"key":"B133","doi-asserted-by":"publisher","DOI":"10.1080\/15592294.2016.1227899"},{"key":"B134","doi-asserted-by":"publisher","DOI":"10.1002\/mc.21864"},{"key":"B135","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2012.08618.x"},{"key":"B136","doi-asserted-by":"publisher","DOI":"10.1159\/000477319"},{"key":"B137","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.01.061"},{"key":"B138","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-016-0348-0"},{"key":"B139","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.04.015"},{"key":"B140","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2018.08.174"},{"key":"B141","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2017.05.061"},{"key":"B142","unstructured":"Jiang XM, Li ZL, Li JL, Zheng WY, Li XH, Cui YF, Sun DJ. LncRNA CCAT1 as the unfavorable prognostic biomarker for cholangiocarcinoma. Eur Rev Med Pharmacol Sci 2017; 21: 1242-1247"},{"key":"B143","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2017.07.025"},{"key":"B144","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-018-0768-6"},{"key":"B145","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.25862"},{"key":"B146","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.06.112"},{"key":"B147","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.21884"},{"key":"B148","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-018-0747-x"},{"key":"B149","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2016-312278"}],"container-title":["World Journal of Gastrointestinal Pathophysiology"],"original-title":[],"link":[{"URL":"https:\/\/www.wjgnet.com\/2150-5330\/full\/v12\/i5\/84.htm","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,15]],"date-time":"2021-09-15T08:26:22Z","timestamp":1631694382000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.wjgnet.com\/2150-5330\/full\/v12\/i5\/84.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,22]]},"references-count":149,"journal-issue":{"issue":"5"},"URL":"https:\/\/doi.org\/10.4291\/wjgp.v12.i5.84","relation":{},"ISSN":["2150-5330"],"issn-type":[{"value":"2150-5330","type":"print"}],"subject":[],"published":{"date-parts":[[2021,9,22]]}}}