{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T20:11:48Z","timestamp":1793045508562,"version":"4.5.0"},"reference-count":39,"publisher":"Baishideng Publishing Group Inc.","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World J Gastrointest Pathophysiol"],"abstract":"<jats:p>Diverticular disease (DD) represents a prevalent clinical challenge, especially in the aging population. The sigmoid colon is the most frequently affected area. However, the presence of DD in the upper gastrointestinal tract, including the duodenum and jejunum, underscores the need for comprehensive understanding and management. In this minireview we analyzed the epidemiology, pathogenesis, clinical presentation, diagnosis, and management of DD with a specific focus on jejunal diverticulosis. Although the incidence of gastrointestinal DD increases with age, the male and female prevalence is the same. Clinical presentation is either asymptomatic or with unclear abdominal symptoms. However, complications such as perforation and bleeding can occur in a subset of patients and demand urgent diagnosis and surgical treatment. Imaging alternatives, including CT and enteroscopy, play key roles in diagnosis. Surgical management is warranted in cases with persistent bleeding or more complicated acute abdomen. Jejunal diverticulosis (JD) is a less common condition and poses a unique diagnostic and therapeutic challenge. Bleeding has been reported as the most important complication in JD. Therefore, early diagnosis and management are critical to improve patient outcomes and reduce morbidity and mortality. This article highlighted the importance of considering JD in the differential diagnosis of gastrointestinal bleeding, especially in patients with concurrent colon diverticulosis in which the bleeding source remains unidentified. Therefore, current challenges in JD are better understanding the etiopathology and optimal management strategies.<\/jats:p>","DOI":"10.4291\/wjgp.v16.i3.109103","type":"journal-article","created":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T01:44:59Z","timestamp":1758246299000},"source":"Crossref","is-referenced-by-count":3,"title":["Jejunal diverticular disease: A gastrointestinal bleeding enigma"],"prefix":"10.4291","volume":"16","author":[{"given":"Roberto","family":"Anaya-Prado","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor J","family":"Avalos-Herrera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aldo A","family":"Silva-Esparza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria J","family":"Alvarez-Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Salazar-Hernandez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Anaya-Fern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan F","family":"Garcia-Ramirez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle Marie","family":"Anaya-Fernandez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Consuelo C","family":"Azcona-Ramirez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean C","family":"Orendain-Luna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norma L","family":"Anaya-Romero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boris","family":"Derechin-Finkel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose E","family":"Alcocer-Escobar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2060","published-online":{"date-parts":[[2025,9,22]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1186\/s13073-024-01374-9"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/795241"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.14744\/nci.2018.23540"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1159\/000381867"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1002\/ccr3.6570"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1186\/1749-7922-6-17"},{"key":"B7","unstructured":"Akhrass R, Yaffe MB, Fischer C, Ponsky J, Shuck JM. Small-bowel diverticulosis: perceptions and reality. J Am Coll Surg 1997; 383-388"},{"key":"B8","doi-asserted-by":"crossref","unstructured":"Ardelt M, Rauchfuss F, Fahrner R, Dondorf F, Hallof G, Ludewig S, Lopatta E, Settmacher U. Complicated Jejunal Diverticulosis: A Retrospective Single-Center Evaluation and a Possible Explanation of Pathogenesis. Am Surg 2017; e455-e458","DOI":"10.1177\/000313481708301114"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1007\/BF02048119"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0b013e3181919261"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1159\/000492069"},{"key":"B12","unstructured":"Amin SK, Antunes C.   Lower Gastrointestinal Bleeding. 2023 Jul 17. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1186\/s40792-020-00929-3"},{"key":"B14","unstructured":"Linzay CD, Pandit S.   Acute Diverticulitis(Archived). 2023 Aug 8. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.4103\/1319-3767.84502"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.14.5916"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.1998.00605.x"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23126698"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.2147\/CEG.S340929"},{"key":"B20","doi-asserted-by":"crossref","unstructured":"Krishnamurthy S, Kelly MM, Rohrmann CA, Schuffler MD. Jejunal diverticulosis. A heterogenous disorder caused by a variety of abnormalities of smooth muscle or myenteric plexus. Gastroenterology 1983; 538-547","DOI":"10.1016\/0016-5085(83)90005-7"},{"key":"B21","unstructured":"Chaussade S, Akue-Goeh K, Grandjouan S, Lemann M, Flourie B, Couturier D, Guerre J. [Intestinal motility in patients with small bowel diverticulosis]. Gastroenterol Clin Biol 1991; 16-21"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1136\/gut.4.2.115"},{"key":"B23","unstructured":"Tsiotos GG, Farnell MB, Ilstrup DM. Nonmeckelian jejunal or ileal diverticulosis: an analysis of 112 cases. Surgery 1994; 726-31; discussion 731"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.21330"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1055\/s-2002-33446"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1055\/s-0028-1109384"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i37.13620"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.23750\/abm.v89i9-S.7924"},{"key":"B29","unstructured":"Piscopo N, Ellul P. Diverticular Disease: A Review on Pathophysiology and Recent Evidence. Ulster Med J 2020; 83-88"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.22516\/25007440.957"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-198811000-00013"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2025.03.002"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.3390\/nu17081365"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0212509"},{"key":"B35","unstructured":"Ibrarullah M, Sikora SS, Saxena R, Kapoor VK, Kackcer L, Awasthi S. Diverticular disease of colon; Indian variant. Trop Gastroenterol 1991; 87-90"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1016\/j.disamonth.2023.101543"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.75127"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-025-03975-z"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1007\/s11547-025-02012-z"}],"container-title":["World Journal of Gastrointestinal Pathophysiology"],"original-title":[],"link":[{"URL":"https:\/\/www.wjgnet.com\/2150-5330\/full\/v16\/i3\/109103.htm","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.wjgnet.com\/2150-5330\/full\/v16\/i3\/109103.htm","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T01:45:28Z","timestamp":1758246328000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.wjgnet.com\/2150-5330\/full\/v16\/i3\/109103.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,22]]},"references-count":39,"journal-issue":{"issue":"3"},"alternative-id":["109103"],"URL":"https:\/\/doi.org\/10.4291\/wjgp.v16.i3.109103","relation":{},"ISSN":["2150-5330"],"issn-type":[{"value":"2150-5330","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9,22]]}}}