{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T04:04:02Z","timestamp":1749009842131,"version":"3.41.0"},"reference-count":51,"publisher":"Baishideng Publishing Group Inc.","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World J Gastrointest Pharmacol Ther"],"abstract":"<jats:p>Functional constipation (FC) in elderly individuals is a significant health issue that adversely affects their quality of life, with recent studies indicating a close relationship between this condition and gut microbiota dysbiosis. This review aims to explore the role of the gut microbiota in FC in elderly individuals, analyze the mechanisms of the gut-brain axis, and evaluate the potential use of microecological agents, including probiotics and prebiotics, in modulating the gut microbiota and alleviating constipation symptoms. By integrating the latest research findings, this study seeks to provide new perspectives and intervention strategies for the management of FC in elderly individuals.<\/jats:p>","DOI":"10.4292\/wjgpt.v16.i2.105242","type":"journal-article","created":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T04:03:22Z","timestamp":1748923402000},"source":"Crossref","is-referenced-by-count":0,"title":["Probiotics and prebiotics in the treatment of functional constipation in the elderly individuals"],"prefix":"10.4292","volume":"16","author":[{"given":"Li","family":"Xu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian-Tang","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming-He","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen","family":"Mo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2060","published-online":{"date-parts":[[2025,6,5]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1093\/gastro\/goab035"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.3390\/nu15081965"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodres.2020.109858"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1007\/s10482-020-01474-7"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-024-10097-4"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.3760\/cma.j.cn441530-20210921-00377"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.3168\/jds.2019-18003"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2023.e19888"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1007\/s12602-024-10395-0"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1590\/1984-3143-AR2023-0082"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.12998\/wjcc.v12.i24.5476"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.4082\/kjfm.18.0182"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1007\/164_2016_111"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1159\/000542156"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1248\/yakushi.20-00176"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/j.cger.2020.08.007"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000001039"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2020.557515"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.20524\/aog.2023.0851"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1007\/s00253-022-12197-2"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2019.00019"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.3390\/nu15214502"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232314928"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2024.110403"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnesp.2022.08.025"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1007\/s12664-023-01435-8"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.40293"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1055\/s-0043-1771470"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.2174\/0118715249271548231115071021"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25073669"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2023.1253874"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.14728"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1038\/s41430-022-01189-0"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.18632\/aging.204266"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2023.e18306"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000027696"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1159\/000063075"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1007\/s12603-020-1494-1"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0244680"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000002028"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114522003853"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1007\/s00394-023-03292-9"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjms.2016.09.014"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1093\/gastro\/goae101"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000039624"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.5056\/jnm20210"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-020-0344-2"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1089\/jmf.2019.4407"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.4103\/jcrt.jcrt_1444_22"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1016\/bs.afnr.2020.06.002"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1016\/bs.afnr.2020.08.001"}],"container-title":["World Journal of Gastrointestinal Pharmacology and Therapeutics"],"original-title":[],"link":[{"URL":"https:\/\/www.wjgnet.com\/2150-5349\/full\/v16\/i2\/105242.htm","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.wjgnet.com\/2150-5349\/full\/v16\/i2\/105242.htm","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T04:03:31Z","timestamp":1748923411000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.wjgnet.com\/2150-5349\/full\/v16\/i2\/105242.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,5]]},"references-count":51,"journal-issue":{"issue":"2"},"alternative-id":["105242"],"URL":"https:\/\/doi.org\/10.4292\/wjgpt.v16.i2.105242","relation":{},"ISSN":["2150-5349"],"issn-type":[{"value":"2150-5349","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6,5]]}}}