{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T15:11:52Z","timestamp":1785337912699,"version":"3.55.0"},"reference-count":25,"publisher":"Baishideng Publishing Group Inc.","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World J Gastrointest Pharmacol Ther"],"abstract":"<jats:p>BACKGROUND<\/jats:p>\n                  <jats:p>Approval of teduglutide is an important addition to the limited treatment options for short bowel syndrome (SBS). However, real-world evidence on teduglutide therapy for SBS in Latin America is scarce.<\/jats:p>\n                  <jats:p>AIM<\/jats:p>\n                  <jats:p>To investigate the effectiveness and safety of teduglutide in clinical practice in Argentina with a 24-week follow-up.<\/jats:p>\n                  <jats:p>METHODS<\/jats:p>\n                  <jats:p>This non-interventional multicentre cohort study included consecutive patients (aged \u2265 1 years) with SBS who were dependent on parenteral support (PS) and received \u2265 1 dose of teduglutide according to currently approved indications.<\/jats:p>\n                  <jats:p>RESULTS<\/jats:p>\n                  <jats:p>The study population (n  = 45) included 21 adult and 24 pediatric patients. The proportion of adult and pediatric patients who showed clinical response (defined as a \u2265 20% reduction in weekly PS volume) after 24 weeks of treatment was 90.4% [95% confidence interval (CI): 69.6%-98.8%] and 83.3% (95%CI: 62.6%-95.2%), respectively. Overall, 12 patients (26.6%; 95%CI: 14.6-41.9) were weaned from PS support at the 24-week assessment, 6 (28.5%; 95%CI: 11.5-52.1) in the adult cohort, and 6 (25%; 95%CI: 9.7-46.7) in the pediatric cohort. Only baseline PS requirement was inversely associated with weaning from PS (P  = 0.025). The most frequently reported treatment-emergent adverse events (TEAEs) were mild to moderate abdominal pain and abdominal distension (16.6%; and 9.5%, respectively). None of the reported TEAEs led to treatment discontinuation.<\/jats:p>\n                  <jats:p>CONCLUSION<\/jats:p>\n                  <jats:p>This prospective real-world study demonstrated the effectiveness and safety of teduglutide in adult and pediatric patients with SBS in Argentina. The clinical response observed in both adults and pediatric patients was greater than that reported in phase 3 trials and was consistent with the results of other real-world studies.<\/jats:p>","DOI":"10.4292\/wjgpt.v16.i4.110642","type":"journal-article","created":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T03:29:21Z","timestamp":1764905361000},"source":"Crossref","is-referenced-by-count":2,"title":["Real-world effectiveness and safety of teduglutide in adult and pediatric patients with short bowel syndrome in Argentina"],"prefix":"10.4292","volume":"16","author":[{"given":"H\u00e9ctor","family":"Solar Mu\u00f1iz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ver\u00f3nica","family":"Busoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda In\u00e9s","family":"Mart\u00ednez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Rumbo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"De Barrio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carola","family":"Saure","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mart\u00edn","family":"Balacco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mart\u00edn Gonzalo","family":"Buncuga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corina","family":"Dlugoszweski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandra","family":"Manzur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorena","family":"Rudi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Dolores","family":"Matoso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Cosentino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Ussher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Manzur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Demarchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Malaver","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Brion","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Ungar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2060","published-online":{"date-parts":[[2025,12,5]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2004.30345.x"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1054\/clnu.1999.0021"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2004.01.036"},{"key":"B4","doi-asserted-by":"crossref","unstructured":"Parrish CR, DiBaise JK. 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