{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T17:58:26Z","timestamp":1781373506541,"version":"3.54.1"},"reference-count":88,"publisher":"Baishideng Publishing Group Inc.","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["WJGPT"],"published-print":{"date-parts":[[2016]]},"DOI":"10.4292\/wjgpt.v7.i3.361","type":"journal-article","created":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T03:05:45Z","timestamp":1470020745000},"page":"361","source":"Crossref","is-referenced-by-count":39,"title":["Infertility in men with inflammatory bowel disease"],"prefix":"10.4292","volume":"7","author":[{"given":"Takeshi","family":"Shin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Okada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2060","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S33961"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2009.09.009"},{"key":"ref3","doi-asserted-by":"crossref","unstructured":"Rossato M, Foresta C. Antisperm antibodies in inflammatory bowel disease. Arch Intern Med 2004;164:2283.","DOI":"10.1001\/archinte.164.20.2283"},{"key":"ref4","doi-asserted-by":"crossref","unstructured":"Moody GA, Probert C, Jayanthi V, Mayberry JF. The effects of chronic ill health and treatment with sulphasalazine on fertility amongst men and women with inflammatory bowel disease in Leicestershire. Int J Colorectal Dis 1997;12:220-224.","DOI":"10.1007\/s003840050093"},{"key":"ref5","doi-asserted-by":"crossref","unstructured":"Narendranathan M, Sandler RS, Suchindran CM, Savitz DA. Male infertility in inflammatory bowel disease. J Clin Gastroenterol 1989;11:403-406.","DOI":"10.1097\/00004836-198908000-00011"},{"key":"ref6","doi-asserted-by":"crossref","unstructured":"Moody GA, Mayberry JF. Perceived sexual dysfunction amongst patients with inflammatory bowel disease. Digestion 1993;54:256-260.","DOI":"10.1159\/000201046"},{"key":"ref7","doi-asserted-by":"crossref","unstructured":"Heetun ZS, Byrnes C, Neary P, O’Morain C. Review article: Reproduction in the patient with inflammatory bowel disease. Aliment Pharmacol Ther 2007;26:513-533.","DOI":"10.1111\/j.1365-2036.2007.03397.x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12478"},{"key":"ref9","unstructured":"Wexner SD, Rosen L, Lowry A, Roberts PL, Burnstein M, Hicks T, Kerner B, Oliver GC, Robertson HD, Robertson WG. Practice parameters for the treatment of mucosal ulcerative colitis--supporting documentation. The Standards Practice Task Force. The American Society of Colon and Rectal Surgeons. Dis Colon Rectum 1997;40:1277-1285."},{"key":"ref10","doi-asserted-by":"crossref","unstructured":"Berg DF, Bahadursingh AM, Kaminski DL, Longo WE. Acute surgical emergencies in inflammatory bowel disease. Am J Surg 2002;184:45-51.","DOI":"10.1016\/S0002-9610(02)00879-6"},{"key":"ref11","doi-asserted-by":"crossref","unstructured":"Gardiner KR, Dasari BV. Operative management of small bowel Crohn’s disease. Surg Clin North Am 2007;87:587-610.","DOI":"10.1016\/j.suc.2007.03.011"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1159\/000434664"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1159\/000438955"},{"key":"ref14","doi-asserted-by":"crossref","unstructured":"Hwang JM, Varma MG. Surgery for inflammatory bowel disease. World J Gastroenterol 2008;14:2678-2690.","DOI":"10.3748\/wjg.14.2678"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2008.90"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i23.7123"},{"key":"ref17","unstructured":"Slors FJ, van Zuijlen PP, van Dijk GJ. Sexual and bladder dysfunction after total mesorectal excision for benign diseases. Scand J Gastroenterol Suppl 2000;48-51."},{"key":"ref18","doi-asserted-by":"crossref","unstructured":"Hueting WE, Buskens E, van der Tweel I, Gooszen HG, van Laarhoven CJ. Results and complications after ileal pouch anal anastomosis: a meta-analysis of 43 observational studies comprising 9,317 patients. Dig Surg 2005;22:69-79.","DOI":"10.1159\/000085356"},{"key":"ref19","doi-asserted-by":"crossref","unstructured":"Berndtsson I, Oresland T, Hultén L. Sexuality in patients with ulcerative colitis before and after restorative proctocolectomy: a prospective study. Scand J Gastroenterol 2004;39:374-379.","DOI":"10.1080\/00365520310008449"},{"key":"ref20","doi-asserted-by":"crossref","unstructured":"Hueting WE, Gooszen HG, van Laarhoven CJ. Sexual function and continence after ileo pouch anal anastomosis: a comparison between a meta-analysis and a questionnaire survey. Int J Colorectal Dis 2004;19:215-218.","DOI":"10.1007\/s00384-003-0543-7"},{"key":"ref21","doi-asserted-by":"crossref","unstructured":"Gorgun E, Remzi FH, Montague DK, Connor JT, O’Brien K, Loparo B, Fazio VW. Male sexual function improves after ileal pouch anal anastomosis. Colorectal Dis 2005;7:545-550.","DOI":"10.1111\/j.1463-1318.2005.00895.x"},{"key":"ref22","doi-asserted-by":"crossref","unstructured":"Farouk R, Pemberton JH, Wolff BG, Dozois RR, Browning S, Larson D. Functional outcomes after ileal pouch-anal anastomosis for chronic ulcerative colitis. Ann Surg 2000;231:919-926.","DOI":"10.1097\/00000658-200006000-00017"},{"key":"ref23","doi-asserted-by":"crossref","unstructured":"Michelassi F, Stella M, Block GE. Prospective assessment of functional results after ileal J pouch-anal restorative proctocolectomy. Arch Surg 1993;128:889-894; discussion 894-895.","DOI":"10.1001\/archsurg.1993.01420200063011"},{"key":"ref24","doi-asserted-by":"crossref","unstructured":"Damgaard B, Wettergren A, Kirkegaard P. Social and sexual function following ileal pouch-anal anastomosis. Dis Colon Rectum 1995;38:286-289.","DOI":"10.1007\/BF02055604"},{"key":"ref25","doi-asserted-by":"crossref","unstructured":"Lindsey I, George BD, Kettlewell MG, Mortensen NJ. Impotence after mesorectal and close rectal dissection for inflammatory bowel disease. Dis Colon Rectum 2001;44:831-835.","DOI":"10.1007\/BF02234703"},{"key":"ref26","doi-asserted-by":"crossref","unstructured":"Lindsey I, George B, Kettlewell M, Mortensen N. Randomized, double-blind, placebo-controlled trial of sildenafil (Viagra) for erectile dysfunction after rectal excision for cancer and inflammatory bowel disease. Dis Colon Rectum 2002;45:727-732.","DOI":"10.1007\/s10350-004-6287-9"},{"key":"ref27","doi-asserted-by":"crossref","unstructured":"Hultén L. Proctocolectomy and ileostomy to pouch surgery for ulcerative colitis. World J Surg 1998;22:335-341.","DOI":"10.1007\/s002689900393"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13142"},{"key":"ref29","doi-asserted-by":"crossref","unstructured":"Levi AJ, Fisher AM, Hughes L, Hendry WF. Male infertility due to sulphasalazine. Lancet 1979;2:276-278.","DOI":"10.1016\/S0140-6736(79)90292-7"},{"key":"ref30","unstructured":"Taffet SL, Das KM. Sulfasalazine. Adverse effects and desensitization. Dig Dis Sci 1983;28:833-842."},{"key":"ref31","doi-asserted-by":"crossref","unstructured":"O'Moráin C, Smethurst P, Doré CJ, Levi AJ. Reversible male infertility due to sulphasalazine: studies in man and rat. Gut 1984;25:1078-1084.","DOI":"10.1136\/gut.25.10.1078"},{"key":"ref32","doi-asserted-by":"crossref","unstructured":"Birnie GG, McLeod TI, Watkinson G. Incidence of sulphasalazine-induced male infertility. Gut 1981;22:452-455.","DOI":"10.1136\/gut.22.6.452"},{"key":"ref33","doi-asserted-by":"crossref","unstructured":"Toovey S, Hudson E, Hendry WF, Levi AJ. Sulphasalazine and male infertility: reversibility and possible mechanism. Gut 1981;22:445-451.","DOI":"10.1136\/gut.22.6.445"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1016\/j.reprotox.2006.10.003"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1016\/j.reprotox.2008.10.007"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1517\/14740338.2011.529898"},{"key":"ref37","doi-asserted-by":"crossref","unstructured":"Wu FC, Aitken RJ, Ferguson A. Inflammatory bowel disease and male infertility: effects of sulfasalazine and 5-aminosalicylic acid on sperm-fertilizing capacity and reactive oxygen species generation. Fertil Steril 1989;52:842-845.","DOI":"10.1016\/S0015-0282(16)53050-7"},{"key":"ref38","doi-asserted-by":"crossref","unstructured":"Cosentino MJ, Chey WY, Takihara H, Cockett AT. The effects of sulfasalazine on human male fertility potential and seminal prostaglandins. J Urol 1984;132:682-686.","DOI":"10.1016\/S0022-5347(17)49824-7"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1136\/"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1007\/BF01536639"},{"key":"ref41","doi-asserted-by":"crossref","unstructured":"Zelissen PM, van Hattum J, Poen H, Scholten P, Gerritse R, te Velde ER. Influence of salazosulphapyridine and 5-aminosalicylic acid on seminal qualities and male sex hormones. Scand J Gastroenterol 1988;23:1100-1104.","DOI":"10.3109\/00365528809090175"},{"key":"ref42","doi-asserted-by":"crossref","unstructured":"Chermesh I, Eliakim R. Mesalazine-induced reversible infertility in a young male. Dig Liver Dis 2004;36:551-552.","DOI":"10.1016\/j.dld.2003.11.030"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.3109\/19396368.2014.952391"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.1016\/j.reprotox.2007.11.010"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2010.224154"},{"key":"ref46","doi-asserted-by":"crossref","unstructured":"Lerman SA, Miller GK, Bohlman K, Albaladejo V, Léonard JF, Devas V, Clark RL. Effects of corticosterone on reproduction in male Sprague-Dawley rats. Reprod Toxicol 1997;11:799-805.","DOI":"10.1016\/S0890-6238(97)00063-4"},{"key":"ref47","doi-asserted-by":"crossref","unstructured":"Roberts AC, McClure RD, Weiner RI, Brooks GA. Overtraining affects male reproductive status. Fertil Steril 1993;60:686-692.","DOI":"10.1016\/S0015-0282(16)56223-2"},{"key":"ref48","doi-asserted-by":"crossref","unstructured":"Burnell D, Mayberry J, Calcraft BJ, Morris JS, Rhodes J. Male fertility in Crohn’s disease. Postgrad Med J 1986;62:269-272.","DOI":"10.1136\/pgmj.62.726.269"},{"key":"ref49","doi-asserted-by":"crossref","unstructured":"Dejaco C, Mittermaier C, Reinisch W, Gasche C, Waldhoer T, Strohmer H, Moser G. Azathioprine treatment and male fertility in inflammatory bowel disease. Gastroenterology 2001;121:1048-1053.","DOI":"10.1053\/gast.2001.28692"},{"key":"ref50","doi-asserted-by":"publisher","DOI":"10.1016\/j.trim.2009.10.001"},{"key":"ref51","doi-asserted-by":"crossref","unstructured":"Ligumsky M, Badaan S, Lewis H, Meirow D. Effects of 6-mercaptopurine treatment on sperm production and reproductive performance: a study in male mice. Scand J Gastroenterol 2005;40:444-449.","DOI":"10.1080\/00365520510011597"},{"key":"ref52","doi-asserted-by":"crossref","unstructured":"Rajapakse RO, Korelitz BI, Zlatanic J, Baiocco PJ, Gleim GW. Outcome of pregnancies when fathers are treated with 6-mercaptopurine for inflammatory bowel disease. Am J Gastroenterol 2000;95:684-688.","DOI":"10.1111\/j.1572-0241.2000.01846.x"},{"key":"ref53","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2004.01889.x"},{"key":"ref54","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2003.50014"},{"key":"ref55","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2010.138"},{"key":"ref56","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.22948"},{"key":"ref57","doi-asserted-by":"crossref","unstructured":"Saxena AK, Dhungel S, Bhattacharya S, Jha CB, Srivastava AK. Effect of chronic low dose of methotrexate on cellular proliferation during spermatogenesis in rats. Arch Androl 2004;50:33-35.","DOI":"10.1080\/01485010490250533"},{"key":"ref58","unstructured":"Shrestha S, Dhungel S, Saxena AK, Bhattacharya S, Maskey D. Effect of methotrexate (MTX) administration on spermatogenesis: an experimental on animal model. Nepal Med Coll J 2007;9:230-233."},{"key":"ref59","doi-asserted-by":"crossref","unstructured":"Sussman A, Leonard JM. Psoriasis, methotrexate, and oligospermia. Arch Dermatol 1980;116:215-217.","DOI":"10.1001\/archderm.1980.01640260091025"},{"key":"ref60","doi-asserted-by":"crossref","unstructured":"El-Beheiry A, El-Mansy E, Kamel N, Salama N. Methotrexate and fertility in men. Arch Androl 1979;3:177-179.","DOI":"10.3109\/01485017908985067"},{"key":"ref61","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ket390"},{"key":"ref62","doi-asserted-by":"publisher","DOI":"10.1002\/ anr.1780321029"},{"key":"ref63","unstructured":"Riba N, Moreno F, Costa J, Olive A. [Appearance of impotence in relation to the use of methotrexate]. Med Clin (Barc) 1996;106:558."},{"key":"ref64","unstructured":"Thomas E, Koumouvi K, Blotman F. Impotence in a patient with rheumatoid arthritis treated with methotrexate. J Rheumatol 2000;27:1821-1822."},{"key":"ref65","doi-asserted-by":"publisher","DOI":"10.1007\/s00795-003-0213-4"},{"key":"ref66","doi-asserted-by":"crossref","unstructured":"Bouloux PM, Wass JA, Parslow JM, Hendry WF, Besser GM. Effect of cyclosporin A in male autoimmune infertility. Fertil Steril 1986;46:81-85.","DOI":"10.1016\/S0015-0282(16)49462-8"},{"key":"ref67","doi-asserted-by":"publisher","DOI":"10.1097\/00005392-199805000-00103"},{"key":"ref68","doi-asserted-by":"crossref","unstructured":"Haberman J, Karwa G, Greenstein SM, Soberman R, Glicklich D, Tellis V, Melman A. Male fertility in cyclosporine-treated renal transplant patients. J Urol 1991;145:294-296.","DOI":"10.1016\/S0022-5347(17)38318-0"},{"key":"ref69","doi-asserted-by":"crossref","unstructured":"Treacy G. Using an analogous monoclonal antibody to evaluate the reproductive and chronic toxicity potential for a humanized anti-TNFalpha monoclonal antibody. Hum Exp Toxicol 2000;19:226-228.","DOI":"10.1191\/096032700678815765"},{"key":"ref70","doi-asserted-by":"publisher","DOI":"10.1097\/01.MIB.0000164023.10848.c4"},{"key":"ref71","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2009.127423"},{"key":"ref72","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2013.10.048"},{"key":"ref73","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.080554"},{"key":"ref74","unstructured":"Puchner R, Danninger K, Puchner A, Pieringer H. Impact of TNF-blocking agents on male sperm characteristics and pregnancy outcomes in fathers exposed to TNF-blocking agents at time of conception. Clin Exp Rheumatol 2012;30:765-767."},{"key":"ref75","doi-asserted-by":"publisher","DOI":"10.2741\/e223"},{"key":"ref76","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2006.10.018"},{"key":"ref77","doi-asserted-by":"crossref","unstructured":"El-Tawil AM. Zinc deficiency in men with Crohn’s disease may contribute to poor sperm function and male infertility. Andrologia 2003;35:337-341.","DOI":"10.1046\/j.0303-4569.2003.00588.x"},{"key":"ref78","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v22.i3.895"},{"key":"ref79","doi-asserted-by":"publisher","DOI":"10.1016\/j.alcohol.2009.10.019"},{"key":"ref80","doi-asserted-by":"crossref","unstructured":"Jowett SL, Seal CJ, Pearce MS, Phillips E, Gregory W, Barton JR, Welfare MR. Influence of dietary factors on the clinical course of ulcerative colitis: a prospective cohort study. Gut 2004;53:1479-1484.","DOI":"10.1136\/gut.2003.024828"},{"key":"ref81","unstructured":"Kalyani R, Basavaraj PB, Kumar ML. Factors influencing quality of semen: a two year prospective study. Indian J Pathol Microbiol 2007;50:890-895."},{"key":"ref82","unstructured":"Emanuele MA, Emanuele NV. Alcohol’s effects on male reproduction. Alcohol Health Res World 1998;22:195-201."},{"key":"ref83","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7827-11-66"},{"key":"ref84","doi-asserted-by":"crossref","unstructured":"Cosnes J. Tobacco and IBD: relevance in the understanding of disease mechanisms and clinical practice. Best Pract Res Clin Gastroenterol 2004;18:481-496.","DOI":"10.1016\/j.bpg.2003.12.003"},{"key":"ref85","doi-asserted-by":"crossref","unstructured":"Zenzes MT. Smoking and reproduction: gene damage to human gametes and embryos. Hum Reprod Update 2000;6:122-131.","DOI":"10.1093\/humupd\/6.2.122"},{"key":"ref86","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2016.04.010"},{"key":"ref87","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-5994.2009.02110.x"},{"key":"ref88","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.20839"}],"container-title":["World Journal of Gastrointestinal Pharmacology and Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.wjgnet.com\/2150-5349\/full\/v7\/i3\/361.htm","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,11]],"date-time":"2019-09-11T20:27:23Z","timestamp":1568233643000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.wjgnet.com\/2150-5349\/full\/v7\/i3\/361.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":88,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016]]}},"URL":"https:\/\/doi.org\/10.4292\/wjgpt.v7.i3.361","relation":{},"ISSN":["2150-5349"],"issn-type":[{"value":"2150-5349","type":"print"}],"subject":[],"published":{"date-parts":[[2016]]}}}