{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T19:07:10Z","timestamp":1790276830515,"version":"4.1.0"},"reference-count":0,"publisher":"African Journals Online (AJOL)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Afr H. Sci."],"abstract":"<jats:p>Background: HBeAg\u2013negative chronic hepatitis B infection has a divergent clinical course from that of HBeAg-positive infection.\r\nObjectives: To analyze the frequency and to compare the different features of HBeAg-negative and HBeAg-positive chron- ic hepatitis B patients.\r\nMethods: One hundred and twenty one Egyptian patients with chronic hepatitis B (CHB), underwent laboratory investiga- tions and transient elastography (TE). Comparisons according to HBeAg status were conducted regarding their demograph- ic, liver biochemical and virologic characters.\r\nResults: 97 patients (80.2%) were HBeAg-negative while 24 patients (19.8%) were HBeAg-positive. HBeAg-negative pa- tients were significantly older in age than CHBeAg-positive patients (p=0.001). ALT levels in HBeAg-negative patients were significantly lower than those in HBeAg-positive patients (p=0.02), whereas serum albumin was lower in the HBeAg-posi- tive group (p=0.03). The percentage of HBV DNA higher than 20000 IU\/mL in HBeAg-negative patients was lower than those in HBeAg-positive patients (p=0.24). Stages of fibrosis by TE showed that 30.9% of HBeAg-negative and 41.7% of HBeAg-positive had a fibrosis score &gt;F2. Four patients (3.3%) were diagnosed with HCC; all of whom were HBeAg-neg- ative.\r\nConclusion: HBeAg-negative patients compared with HBeAg-positive patients had older age, lower ALT and serum HBV- DNA levels, but more incidence of HCC.\r\nKeywords: Hepatitis B; HBeAg; fibrosis; Egypt.<\/jats:p>","DOI":"10.4314\/ahs.v20i2.13","type":"journal-article","created":{"date-parts":[[2020,9,8]],"date-time":"2020-09-08T08:52:08Z","timestamp":1599555128000},"page":"649-655","source":"Crossref","is-referenced-by-count":12,"title":["Analysis of clinical and virologic features in Hepatitis B e Antigen (HbeAg)-negative and HbeAg-positive Egyptian chronic Hepatitis B patients"],"prefix":"10.4314","volume":"20","author":[{"given":"Rabab","family":"Fouad","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sherief","family":"Musa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dina","family":"Sabry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad","family":"Salama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shereen","family":"Abdel Alem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mira","family":"Atef","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naglaa","family":"Zayed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2895","published-online":{"date-parts":[[2020,7,22]]},"container-title":["African Health Sciences"],"original-title":[],"link":[{"URL":"https:\/\/www.ajol.info\/index.php\/ahs\/article\/download\/197835\/186580","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajol.info\/index.php\/ahs\/article\/download\/197835\/186580","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,8]],"date-time":"2020-09-08T08:52:42Z","timestamp":1599555162000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajol.info\/index.php\/ahs\/article\/view\/197835"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,22]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2020,7,23]]}},"URL":"https:\/\/doi.org\/10.4314\/ahs.v20i2.13","relation":{},"ISSN":["1680-6905"],"issn-type":[{"value":"1680-6905","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,22]]}}}