{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T11:45:43Z","timestamp":1787312743936,"version":"build-2736575974"},"reference-count":0,"publisher":"African Journals Online (AJOL)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Afr H. Sci."],"abstract":"<jats:p>Background: Activation of immunological and systemic inflammation markers are common in obesity and asthma.\r\nObjective: The target of this study was to assess impact of weight reduction on immunological and systemic inflammation markers in obese asthma patients.\r\nMaterial and methods: Eighty asthmatic patients of both sex; their age and body mass index (BMI) mean were 38.72 \u00b1 7.14 year and 32.65 \u00b1 3.18 Kg\/m2 respectively. Exclusion criteria included smokers, infections, vaccinations, cancer, surgery, immune system disorders and medications that may influence immune system function as anti-inflammatory medications, analgesics and anti-depressant. All subjects were randomly enrolled in weight reduction group (group A) or control group (group B).\r\nResults: The main findings in the present study indicated that weight reducing program in group (A) was associated with significant reduction in the mean values of IL6, TNF-\u03b1, and IL8 in addition to significant increase in the mean values of CD4 and CD8 cell count . However, findings of group (B) showed no significant changes. Moreover, Comparison between both groups at the end of the study revealed significant differences.\r\nConclusion: Weight reduction improved immunological and systemic inflammation markers in obese asthma patients.\r\nKeywords: Bronchial asthma; cytokines; obesity; immune system; weight reduction.<\/jats:p>","DOI":"10.4314\/ahs.v20i2.44","type":"journal-article","created":{"date-parts":[[2020,9,8]],"date-time":"2020-09-08T04:52:08Z","timestamp":1599540728000},"page":"897-902","source":"Crossref","is-referenced-by-count":18,"title":["Weight reduction improves immune system and inflammatory cytokines in obese asthmatic patients"],"prefix":"10.4314","volume":"20","author":[{"given":"Fadwah","family":"M Al-Sharif","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shehab","family":"M Abd El-Kader","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyad","family":"A Neamatallah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Afnan","family":"M AlKhateeb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2895","published-online":{"date-parts":[[2020,7,22]]},"container-title":["African Health Sciences"],"original-title":[],"link":[{"URL":"https:\/\/www.ajol.info\/index.php\/ahs\/article\/download\/197919\/186667","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajol.info\/index.php\/ahs\/article\/download\/197919\/186667","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,8]],"date-time":"2020-09-08T04:52:21Z","timestamp":1599540741000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajol.info\/index.php\/ahs\/article\/view\/197919"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,22]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2020,7,23]]}},"URL":"https:\/\/doi.org\/10.4314\/ahs.v20i2.44","relation":{},"ISSN":["1680-6905"],"issn-type":[{"value":"1680-6905","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,22]]}}}