{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T22:39:30Z","timestamp":1789684770748,"version":"4.0.1"},"reference-count":0,"publisher":"African Journals Online (AJOL)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Afr H. Sci."],"abstract":"<jats:p>Background and Objective: Chronic inflammation is the typical sign of gastritis that may shift into gastric cancer. IL- 17A and IL-17F as a novel inflammatory cytokines subset of CD4+Th play the main role in inflammation. A key cytokine receptor in the inflammatory IL-17\/IL-23 axis, the interleukin 23 receptor (IL23R), may be related to gastritis. We evaluated the correspondence between IL-17A G197A, IL-17F A7488G and IL23R+2199 A\/C polymorphisms with TGF-\u03b21, IL-6, IL-17, IL-21 and IL-23 mucosal mRNAs expression in uninfected H. Pylori (HP) chronic gastritis patients.\r\nMaterials and Methods: Total RNA and genomic DNA were separated from gastric biopsies of 44 patients with gastritis. Subsequently, mucosal mRNAs expression of TGF-\u03b21, IL-6, IL-17, IL-21 and IL-23 were assessed by real-time PCR. To polymorphisms determination of IL-17A G197A, IL-17F A7488G and IL-23R +2199A\/C the PCR-RFLP was used in gastric biopsies.\r\nResults: Results point that IL-17A G197A, IL-17F A7488G and IL23R +2199A\/C polymorphisms did not influence the mucosal expression of TGF-\u03b21, IL-6, IL-17 and IL-21 (p&gt; 0.05). In an opposite result, we don\u2019t find a correspondence between IL-17A G197A, IL-17F A7488G polymorphisms and mucosal expression of IL-23 (p&gt; 0.05). In a contrary, we found a correlation between IL23R +2199A\/C polymorphism and mucosal expression of IL-23 in patients with chronic gastritis (p&lt; 0.05).\r\nConclusion: These findings propose that IL23R +2199A\/C polymorphism may change the mucosal expression of IL-23 pattern in patients with gastritis disease in the absence of HP, but to support the conclusion, more research may be required.\r\nKeywords: Cytokines; polymorphism; gastritis; IL-23, IL-17.<\/jats:p>","DOI":"10.4314\/ahs.v20i3.51","type":"journal-article","created":{"date-parts":[[2020,10,9]],"date-time":"2020-10-09T11:17:55Z","timestamp":1602242275000},"page":"1452-1462","source":"Crossref","is-referenced-by-count":4,"title":["From genes polymorphisms to mucosal expression of cytokines: evaluating IL-23\/IL-17 axis in adult patients with gastritis"],"prefix":"10.4314","volume":"20","author":[{"given":"Fatemeh","family":"Azadegan-Dehkordi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ardeshir","family":"Abbasi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amin","family":"Talebi Bezmin Abadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khaled","family":"Minooie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parya","family":"Aslani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Razieh","family":"Sadat Hosseini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farid","family":"Zandi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2895","published-online":{"date-parts":[[2020,10,7]]},"container-title":["African Health Sciences"],"original-title":[],"link":[{"URL":"https:\/\/www.ajol.info\/index.php\/ahs\/article\/download\/200353\/188954","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajol.info\/index.php\/ahs\/article\/download\/200353\/188954","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,9]],"date-time":"2020-10-09T11:18:00Z","timestamp":1602242280000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajol.info\/index.php\/ahs\/article\/view\/200353"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,7]]},"references-count":0,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2020,10,7]]}},"URL":"https:\/\/doi.org\/10.4314\/ahs.v20i3.51","relation":{},"ISSN":["1680-6905"],"issn-type":[{"value":"1680-6905","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,7]]}}}