{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,2]],"date-time":"2022-04-02T06:19:44Z","timestamp":1648880384101},"reference-count":0,"publisher":"African Journals Online (AJOL)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Afr H. Sci."],"abstract":"<jats:p>Background: Co-infection of High Risk Human Papillomavirus (HR-HPV) and HIV is thought to favour initiation of intraepithelial squamous cell lesion and subsequent progression to cervical carcinoma.&#x0D;\nObjectives: Evaluation of cytological physiognomies in relation to possible age influence and the genotype distribution of human papillomaviruses among HPV\/HIV co-infected and HPV monoinfected women in Kisii, Kenya.&#x0D;\nMethods: The case-control study enrolled 42 HPV\/HIV co-infected and 42 HPV monoinfected women. Cervical swabs were collected in ThinPrep vials for HPV tying and cytological analysis. HPV subtypes were assayed by Xpert\u00ae HPV system (GXHPV-CE-10).&#x0D;\nResults: Mono-infected women aged 30-39 years had the highest proportion of low grade squamous intraepithelial lesion (LSIL) at 14 (16.67%) while the co-infected aged 50-59 years had the highest proportion of high grade squamous intraepi- thelial lesion (HSIL) at 9 (10.71%). HPV-16 genotype was the most predominant and it increased with age rise. Older coin- fected and mono-infected women (&gt;40 years) had HSIL and LSIL as the most predominant cytological grade respectively.&#x0D;\nConclusion: The predominance of HPV-16 and HPV-18\/45 genotypes in the study setting is a consideration that would benefit targeted prophylactic vaccination programs. HPV testing and cervical cancer screening for young and older women on a regular basis ought to be reinforced.&#x0D;\nKeywords: Human immunodeficiency virus (HIV); Human Papillomavirus (HPV); co-infection; genotype; cytology.<\/jats:p>","DOI":"10.4314\/ahs.v21i1.33","type":"journal-article","created":{"date-parts":[[2021,4,19]],"date-time":"2021-04-19T13:18:29Z","timestamp":1618838309000},"page":"254-62","source":"Crossref","is-referenced-by-count":0,"title":["Cytological physiognomies and genotype distribution of human papillomaviruses among HPV\/HIV co-infected and HPV mono-infected women"],"prefix":"10.4314","volume":"21","author":[{"given":"Lucy","family":"Wanja Karani","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stanslaus","family":"Musyoki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Orina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"Khayeka-Wandabwa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benuel","family":"Nyagaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2895","published-online":{"date-parts":[[2021,4,16]]},"container-title":["African Health Sciences"],"original-title":[],"link":[{"URL":"https:\/\/www.ajol.info\/index.php\/ahs\/article\/download\/206065\/194308","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajol.info\/index.php\/ahs\/article\/download\/206065\/194308","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,27]],"date-time":"2021-05-27T08:45:40Z","timestamp":1622105140000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajol.info\/index.php\/ahs\/article\/view\/206065"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,16]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2021,4,16]]}},"URL":"https:\/\/doi.org\/10.4314\/ahs.v21i1.33","relation":{},"ISSN":["1680-6905"],"issn-type":[{"value":"1680-6905","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,16]]}}}