{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T21:13:47Z","timestamp":1790111627033,"version":"4.0.1"},"reference-count":0,"publisher":"African Journals Online (AJOL)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Afr H. Sci."],"abstract":"<jats:p>Objective: The potential correlation between the \u03b52\/\u03b53\/\u03b54 variants of the ApoE (Apolipoprotein E) gene and the odds of mesial temporal lobe epilepsy was investigated.\r\nMethods: The database searching for eligible studies was performed in October 2020. A series of pooling analyses were conducted.\r\nResults: We enrolled a total of twelve case-control studies for pooling. Within the pooling analysis of \u03b54, there was an in- creased risk of mesial temporal lobe epilepsy in cases under the models of carrier \u03b54 vs. \u03b53, \u03b53\u03b54 vs. \u03b53\u03b53, and \u03b53\u03b54+\u03b54\u03b54 vs. \u03b53\u03b53 [P &lt; 0.05, odds ratio (OR) &gt; 1], compared with controls. Moreover, we observed similar positive results in the subgroup analyses of \u201cChina\u201d and \u201cPopulation-based control\u201d under the genetic models of \u03b54 (P &lt; 0.05, OR &gt; 1). Nevertheless, we did not detect the significant difference between the mesial temporal lobe epilepsy cases and controls in the pooling analyses of \u03b52 (all P &gt; 0.05).\r\nConclusion: The \u03b53\u03b54 genotype of ApoE seems to be linked to the risk of mesial temporal lobe epilepsy for patients in China. More sample sizes are required to confirm the potential role of ApoE isoforms in the susceptibility to diverse types of epilepsy from different origins.\r\nKeywords: Epilepsy; ApoE; isoforms; susceptibility.<\/jats:p>","DOI":"10.4314\/ahs.v21i2.48","type":"journal-article","created":{"date-parts":[[2021,8,4]],"date-time":"2021-08-04T09:26:11Z","timestamp":1628069171000},"page":"866-874","source":"Crossref","is-referenced-by-count":4,"title":["Genetic influence of Apolipoprotein E gene \u03b52\/\u03b53\/\u03b54 isoforms on odds of mesial temporal lobe epilepsy"],"prefix":"10.4314","volume":"21","author":[{"given":"Tao","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueliang","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuping","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2895","published-online":{"date-parts":[[2021,8,2]]},"container-title":["African Health Sciences"],"original-title":[],"link":[{"URL":"https:\/\/www.ajol.info\/index.php\/ahs\/article\/download\/211799\/199725","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajol.info\/index.php\/ahs\/article\/download\/211799\/199725","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,4]],"date-time":"2021-08-04T09:26:36Z","timestamp":1628069196000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajol.info\/index.php\/ahs\/article\/view\/211799"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,2]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2021,8,3]]}},"URL":"https:\/\/doi.org\/10.4314\/ahs.v21i2.48","relation":{},"ISSN":["1680-6905"],"issn-type":[{"value":"1680-6905","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,2]]}}}