{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T05:33:29Z","timestamp":1787031209071,"version":"build-2736575974"},"reference-count":0,"publisher":"African Journals Online (AJOL)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Afr H. Sci."],"abstract":"<jats:p>Background: The prevalence of allergic diseases is gradually increasing worldwide. The most common such allergic disease is allergic rhinitis (AR).\r\nObjective: The present study investigated the possible relationship between seasonal AR and the thiol-disulfide balance and zinc and copper levels in adult individuals.\r\nStudy Design and Methods: 130 male and female adults were included in the study. The participants\u2019 serum thiol-disulfide balance and zinc and copper levels were measured spectrophotometrically using commercial kits. Statistical significance was accepted as p &lt; 0.05 between the groups.\r\nResults: The serum copper (p = 0.001), native thiol (p = 0.006), reduced thiol (p &lt; 0.001), and thiol oxidation reduction ratio (p &lt; 0.001) levels were significantly lower in the seasonal AR group than in the control group.\r\nConclusion: In AR patients, the low level of copper, which is an important trace element, the deterioration of the thiol-disulfide balance, which represents a unique indicator of the oxidant-antioxidant balance, the increased disulfide level caused by oxidative stress, and the decreased native thiol level can all serve as important biochemical markers.\r\nKeywords: Seasonal allergic rhinitis; native thiol; disulfide; oxidative stress; copper.<\/jats:p>","DOI":"10.4314\/ahs.v22i3.34","type":"journal-article","created":{"date-parts":[[2022,11,15]],"date-time":"2022-11-15T08:21:53Z","timestamp":1668500513000},"page":"322-328","source":"Crossref","is-referenced-by-count":5,"title":["Thiol\u2013disulfide balance and trace element levels in patients with seasonal allergic rhinitis"],"prefix":"10.4314","volume":"22","author":[{"given":"Hasan","family":"Basri Savas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huseyin","family":"Gunizi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2895","published-online":{"date-parts":[[2022,10,28]]},"container-title":["African Health Sciences"],"original-title":[],"link":[{"URL":"https:\/\/www.ajol.info\/index.php\/ahs\/article\/download\/234924\/221927","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajol.info\/index.php\/ahs\/article\/download\/234924\/221927","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,15]],"date-time":"2022-11-15T08:23:13Z","timestamp":1668500593000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajol.info\/index.php\/ahs\/article\/view\/234924"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,28]]},"references-count":0,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2022,10,28]]}},"URL":"https:\/\/doi.org\/10.4314\/ahs.v22i3.34","relation":{},"ISSN":["1729-0503","1680-6905"],"issn-type":[{"value":"1729-0503","type":"electronic"},{"value":"1680-6905","type":"print"}],"subject":[],"published":{"date-parts":[[2022,10,28]]}}}