{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T12:04:04Z","timestamp":1785240244884,"version":"3.55.0"},"reference-count":0,"publisher":"African Journals Online (AJOL)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Afr H. Sci."],"abstract":"<jats:p>Setting-Objective: In this study, it was aimed to reveal the incidence of tuberculosis development in patients receiving tumor necrosis factor-alpha (TNF-\u03b1) blocker therapy, despite tuberculosis chemoprophylaxis.\r\nDesign: 520 patients who were receiving anti TNF-\u03b1 treatment in the last 3 years were evaluated retrospectively. Radiological imaging tuberculin skin test (TST), history of tuberculosis, BCG vaccine, chemoprophylaxis administration, used anti TNF-\u03b1 drugs were recorded.\r\nResults: There were 265(51.0%) of the patients with ankylosing spondylitis (AS), 175(33.7%) with rheumatoid arthritis, 35(6.7%) with Crohn's, 10(1.9%) with ulcerative colitis (UC), 21(4.0%) with psoriatic arthritis, 14(2.7%) with psoriasis vulgaris. In total, 455 (79.6%) patients were given INH prophylaxis. Active tuberculosis development was observed in five patients (4: pulmonary,1: extrapulmonary; 3: UC, 2:AS) who all received anti TNF-\u03b1 treatment (0.96%), infliximab. Three patients had tuberculosis disease in the 6th month, and the other 2 patients in the 5th and 24th month of their anti TNF-\u03b1 treatments, and two had 9-month, and 1 had 6-month chemoprophylaxis history.\r\nConclusion: The incidence of tuberculosis development in patients treated with anti TNF-\u03b1 was found to be higher than the general population. In our country, where tuberculosis is still prevalent, patients receiving Anti TNF-\u03b1 treatment (especially infliximab) should be carefully questioned and examined about tuberculosis.\r\nKeywords: Anti-TNF-alpha; tuberculosis; tuberculin skin test.<\/jats:p>","DOI":"10.4314\/ahs.v23i2.14","type":"journal-article","created":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T14:38:34Z","timestamp":1697121514000},"page":"128-32","source":"Crossref","is-referenced-by-count":6,"title":["Frequency of latent tuberculosis in patients receiving Anti-TNF-Alpha therapy"],"prefix":"10.4314","volume":"23","author":[{"given":"\u0130pek","family":"Co\u015fkunol","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Onur","family":"Turan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aysegul","family":"Baysak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dilek","family":"Solmaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ger\u00e7ek","family":"Can","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2895","published-online":{"date-parts":[[2023,7,13]]},"container-title":["African Health Sciences"],"original-title":[],"link":[{"URL":"https:\/\/www.ajol.info\/index.php\/ahs\/article\/download\/250617\/236939","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajol.info\/index.php\/ahs\/article\/download\/250617\/236939","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T14:40:49Z","timestamp":1697121649000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajol.info\/index.php\/ahs\/article\/view\/250617"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,13]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2023,7,13]]}},"URL":"https:\/\/doi.org\/10.4314\/ahs.v23i2.14","relation":{},"ISSN":["1729-0503","1680-6905"],"issn-type":[{"value":"1729-0503","type":"electronic"},{"value":"1680-6905","type":"print"}],"subject":[],"published":{"date-parts":[[2023,7,13]]}}}