{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T18:39:50Z","timestamp":1776191990965,"version":"3.50.1"},"reference-count":0,"publisher":"African Journals Online (AJOL)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Afr H. Sci."],"abstract":"<jats:p>Introduction: Sickle cell syndrome (SCS) represent a real health problem. In this work, we propose to study the epidemiological and clinical features of 66 patients with SCS.\r\nMethods: This is a retrospective descriptive cross-sectional study carried out on a population of 66 patients with SCS, (36 S\/S, 18 S\/\u03b2-thalassemia, seven S\/C and five S\/OArab), over a period of two years.\r\nResults: The average age of our population is 15.5 years \u00b1 8.4. 36 patients (55%) were born to a consanguineous marriage and 35 (53%) had siblings with SCS. The average baseline hemoglobin in our patients is 9.1g\/dL\u00b11.51. S\/C patients have significantly higher baseline hemoglobin than S\/S, S\/\u03b2-thalassemia and S\/OArab with p &lt;0.05. Jaundice, mucosal skin pallor and hepatomegaly have been observed only in S\/S, S\/\u03b2-thalassemia and S\/OArab patients. The persistence of splenomegaly is more frequent in S\/C than in S\/S, and in S\/-thalassemia than in S\/S. The most common acute complications were vaso-occlusive attacks (69.7%) and worsening of anemia (54.54%). The most common chronic complication was cholelithiasis (36.36%).\r\nConclusion: S\/C patients present the best tolerated form and were the least affected by chronic complications and therefore can lead an almost normal life.\r\nKeywords: Acute complications; chronic complications; sickle cell syndrome; steady state.<\/jats:p>","DOI":"10.4314\/ahs.v23i3.26","type":"journal-article","created":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T14:38:44Z","timestamp":1697121524000},"source":"Crossref","is-referenced-by-count":2,"title":["Epidemiological and clinical characteristics of 66 Tunisian Sickle cell syndrome patients"],"prefix":"10.4314","volume":"23","author":[{"given":"Ahlem","family":"Sahli","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Faida","family":"Ouali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rym","family":"Dabboubi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sondess","family":"Hadj Fredj","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nabila","family":"Meddeb","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naila","family":"Mzoughi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taieb","family":"Messaoud","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2895","published-online":{"date-parts":[[2023,10,11]]},"container-title":["African Health Sciences"],"original-title":[],"link":[{"URL":"https:\/\/www.ajol.info\/index.php\/ahs\/article\/download\/256878\/242647","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajol.info\/index.php\/ahs\/article\/download\/256878\/242647","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T14:40:24Z","timestamp":1697121624000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajol.info\/index.php\/ahs\/article\/view\/256878"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,11]]},"references-count":0,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2023,10,11]]}},"URL":"https:\/\/doi.org\/10.4314\/ahs.v23i3.26","relation":{},"ISSN":["1729-0503","1680-6905"],"issn-type":[{"value":"1729-0503","type":"electronic"},{"value":"1680-6905","type":"print"}],"subject":[],"published":{"date-parts":[[2023,10,11]]}}}