{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T14:19:57Z","timestamp":1772461197460,"version":"3.50.1"},"reference-count":0,"publisher":"African Journals Online (AJOL)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Afr H. Sci."],"abstract":"<jats:p>Background: Hypoxia is the hallmark of iron deficiency anemia (IDA) and in hypoxic environment, significant changes are observed in malignancy-related microRNAs (miRNA). Our aim is to examine whether there is any difference in the levels of miR-210, miR-373 and let-7, which are directly related to malignancies in patients with IDA.\r\nMethods: Thirty-five female patients with IDA between the ages of 18-65 and 10 healthy controls were included in the study. Patients who received oral iron therapy, who had inflammatory disease, and who were pregnant were excluded from the study. Student t Test was used for comparing variables with normal distribution in two independent groups, and Mann-Whitney U Test was used for variables without normal distribution. Comparison of categorical data was made using the chi-square test.\r\nResults: The mean hemoglobin and ferritin level were 10,78\u00b10,93 and 6.28\u00b15,76 respectively. Plasma miR-210 expression were found as -7.27\u00b12.23 and -6.15\u00b10,88 in IDA and control group respectively (p = 0.022). Plasma miRNA-373 were -7.36\u00b12,58 and -6,96\u00b11,93 and let-7 expression were 2.14\u00b12,15 and 3,57\u00b12,21 in IDA and control group. (p = 0.65 and p = 0.20, respectively).\r\nConclusions: Plasma miR-210 expression was significantly up-regulated and miR-373 and let-7 expression was down-regulated, though insignificantly, in IDA group.\r\nKeywords: miRNA; iron deficiency anemia; malignancy.<\/jats:p>","DOI":"10.4314\/ahs.v23i3.30","type":"journal-article","created":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T14:38:44Z","timestamp":1697121524000},"source":"Crossref","is-referenced-by-count":1,"title":["Malignancy-related mir-210, mir-373 and let-7 levels are affected in iron deficiency anemia"],"prefix":"10.4314","volume":"23","author":[{"given":"Ruveyda","family":"Sak","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Demircan","family":"Ozbalci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emine","family":"Guchan Alanoglu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kuyas","family":"Hekimler Ozturk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2895","published-online":{"date-parts":[[2023,10,11]]},"container-title":["African Health Sciences"],"original-title":[],"link":[{"URL":"https:\/\/www.ajol.info\/index.php\/ahs\/article\/download\/256897\/242666","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajol.info\/index.php\/ahs\/article\/download\/256897\/242666","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T14:40:18Z","timestamp":1697121618000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajol.info\/index.php\/ahs\/article\/view\/256897"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,11]]},"references-count":0,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2023,10,11]]}},"URL":"https:\/\/doi.org\/10.4314\/ahs.v23i3.30","relation":{},"ISSN":["1729-0503","1680-6905"],"issn-type":[{"value":"1729-0503","type":"electronic"},{"value":"1680-6905","type":"print"}],"subject":[],"published":{"date-parts":[[2023,10,11]]}}}