{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,4,5]],"date-time":"2024-04-05T00:46:08Z","timestamp":1712277968512},"reference-count":0,"publisher":"African Journals Online (AJOL)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Afr H. Sci."],"abstract":"<jats:p>Introduction: The causative agent of COVID-19 (Coronavirus Disease 2019) is an enveloped RNA (ribonucleic acid) virus of the SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus-2) family. The effects of SARS-CoV-2 on the differentiation and maturation of blood cells have been the subject of several studies, we report our experience of an investigation of the morphologic abnormalities of leukocytes observed during COVID-19.Patients and methods: This is a prospective study of 5 months, from February 2021 to June 2021. Forty COVID-19 patients and 20 healthy controls were included in this study. We performed complete blood count and peripheral blood smear of all patients and control samples. Leukocytes abnormalities were quantified as a percentage of 100 leukocytes of the same lineage.Results: The morphological abnormalities of the leukocytes found in percentage of patients have been mainly neutrophils bilobed 72,5%, hypogranulation 45%, acquired pseudo Pelger-Huet 35%, vacuolated neutrophils 42,5%, Apoptotic neutrophils 35,5 %, neutrophils with toxic granulations 30%, myelemia 45%, atypical lymphocytes 52,5%, lymphoplasmocytes 60% and vacuolated monocytes 27, 5%.Conclusion: Our study revealed several morphological abnormalities of the different cells of the leukocyte lineage. The presence of toxic granulations in the cytoplasm of the myelocytes was specific to this study.<\/jats:p>","DOI":"10.4314\/ahs.v23i4.13","type":"journal-article","created":{"date-parts":[[2024,4,4]],"date-time":"2024-04-04T10:22:53Z","timestamp":1712226173000},"page":"102-107","source":"Crossref","is-referenced-by-count":0,"title":["Morphological abnormalities of leukocytes in SARS-CoV-2 infection"],"prefix":"10.4314","volume":"23","author":[{"given":"Amine","family":"Moueden","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reda","family":"Messaoudi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mokhtar","family":"Derouiche","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2895","published-online":{"date-parts":[[2023,12,27]]},"container-title":["African Health Sciences"],"original-title":[],"link":[{"URL":"https:\/\/www.ajol.info\/index.php\/ahs\/article\/download\/261317\/246671","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajol.info\/index.php\/ahs\/article\/download\/261317\/246671","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,4]],"date-time":"2024-04-04T10:25:50Z","timestamp":1712226350000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajol.info\/index.php\/ahs\/article\/view\/261317"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,27]]},"references-count":0,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2023,12,27]]}},"URL":"https:\/\/doi.org\/10.4314\/ahs.v23i4.13","relation":{},"ISSN":["1729-0503","1680-6905"],"issn-type":[{"value":"1729-0503","type":"electronic"},{"value":"1680-6905","type":"print"}],"subject":[],"published":{"date-parts":[[2023,12,27]]}}}