{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T15:58:07Z","timestamp":1783180687367,"version":"3.54.6"},"reference-count":0,"publisher":"African Journals Online (AJOL)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Afr H. Sci."],"abstract":"<jats:p>Objective: Vitamin D (Vit D) deficiency correlates women reproductive pathophysiology. We analyzed Vit D deficiency biomarkers in infertile women.\r\nPatients &amp; method: This case-control study enrolled 80 infertile women polycystic ovary syndrome (PCOS), and other etiologies; anovulation and unexplained and 25 controls. Serum calcidiol and calcitriol were determined by ELISA and their direct ratio was calculated.\r\nResults: 72% of controls and 92.5% of patients had Vit D deficiency\/insufficiency (calcidiol mean \u00b1 SDM of 33.50\u00b122.10 vs 20.26\u00b15.226 ng\/mL and an AUC of 0.808\u00b10.048). Calcitriol had an AUC of 0.909\u00b10.031 that more effectively distinguished patients and etiologies (53.49\u00b123.30 pg\/mL) from controls (114.0\u00b143.20 pg\/mL; P&lt;0.001). 4 other etiology cases and 17 controls had calcitriol levels \u2265100 pg\/mL. 64% of controls (4.090\u00b10.020) and 16.25% of patients [2.634\u00b10.855, P&lt;0.04; 5 PCOS (3 primary\/2 secondary), 3 secondary unexplained, and 5 others (one primary tubal, one primary\/one secondary peritoneal, one primary\/one cervical and one primary tubal had a normal ratio \u22653.333 at an AUC of 0.740\u00b10.065. All biomarkers revealed patient levels ~50% lower than controls; lowest in PCOS and unexplained etiologies.\r\nConclusion: Vit D levels are significantly reduced in infertile women; lowest in PCOS and unexplained etiology, for all biomarkers, where calcitriol was the optimal predictor of both infertility and etiology.\r\nKeywords: Female infertility, Polycystic ovary syndrome; unexplained infertility; Vitamin D; 25-Hydroxy-cholecalceferol, 1; 25-Dihydroxyl-cholecalceferol.<\/jats:p>","DOI":"10.4314\/ahs.v24i3.30","type":"journal-article","created":{"date-parts":[[2024,10,15]],"date-time":"2024-10-15T12:54:09Z","timestamp":1728996849000},"page":"259-273","source":"Crossref","is-referenced-by-count":2,"title":["Women\u2019s fertility and vitamin D: Could hypovitaminosis D biomarkers correlate with  the disease, and explain the unexplained female factor infertility?"],"prefix":"10.4314","volume":"24","author":[{"given":"Albahlol","family":"Ibrahim A","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alshaikh","family":"Ahmed Baker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Almaeen","family":"Abdulrahman H","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alduraywish","family":"Abdulrahman A","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dar","family":"Umar Farooq","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"El-Metwally","family":"Tarek H","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2895","published-online":{"date-parts":[[2024,10,6]]},"container-title":["African Health Sciences"],"original-title":[],"link":[{"URL":"https:\/\/www.ajol.info\/index.php\/ahs\/article\/download\/280059\/264158","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajol.info\/index.php\/ahs\/article\/download\/280059\/264158","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,15]],"date-time":"2024-10-15T12:54:30Z","timestamp":1728996870000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajol.info\/index.php\/ahs\/article\/view\/280059"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,6]]},"references-count":0,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2024,10,6]]}},"URL":"https:\/\/doi.org\/10.4314\/ahs.v24i3.30","relation":{},"ISSN":["1729-0503","1680-6905"],"issn-type":[{"value":"1729-0503","type":"electronic"},{"value":"1680-6905","type":"print"}],"subject":[],"published":{"date-parts":[[2024,10,6]]}}}