{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T03:21:56Z","timestamp":1787800916472,"version":"build-2784847793"},"reference-count":0,"publisher":"African Journals Online (AJOL)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Afr H. Sci."],"abstract":"<jats:p>Background: In this study, we aimed to investigate the added prognostic value of fat attenuation index (FAI) and CT-derivedfractional flow (CT-FFR) over plaque burden in suspected coronary artery disease (CAD) patients without standard modifiablerisk factors (SMuRFs).\r\nMethodology: A total of 260 consecutive suspected CAD subjects without SMuRFs who underwent first coronary computed tomography angiography (CCTA) were retrospectively collected. We calculated FAI, CT-FFR, and segment involvement score (SIS) from CCTA images. Cox regression models were used to assess the incremental prognostic value of FAI and CT-FFR.\r\nResults: During a median follow-up of 25.00 months, major adverse cardiovascular events (MACE) were observed in 40 (15.4%) patients. FAI \u2265 \u221270.1, CT-FFR \u2264 0.80, and SIS \u2265 4.5 were associated with the increased rate of MACE (P &lt; 0.0001). FAI did not provide incremental prognostic value over SIS (P = 0.169). Likewise, CT-FFR did not enhance risk prediction (P = 0.159). Combining FAI and CT-FFR added incremental prediction value and improved risk discrimination (P = 0.032; Absolute integrate discrimination improvement (IDI) = 0.070, P &lt; 0.001).\r\nConclusion: In suspected CAD patients without SMuRFs, neither FAI nor CT-FFR independently added incremental prognostic value over plaque burden. Combining FAI and CT-FFR had added prognostic value and improved cardiovascular risk stratification.\r\nKeywords: Coronary artery disease; CT-derived fractional flow reserve; fat attenuation index; plaque burden; standard cardiovascularrisk factor; prognosis.<\/jats:p>","DOI":"10.4314\/ahs.v24i3.49","type":"journal-article","created":{"date-parts":[[2024,10,15]],"date-time":"2024-10-15T12:54:09Z","timestamp":1728996849000},"page":"444-452","source":"Crossref","is-referenced-by-count":5,"title":["Added prognostic value of fat attenuation index and CT-derived fractional flow reserve over plaque burden in suspected CAD patients without standard modifiable risk factors"],"prefix":"10.4314","volume":"24","author":[{"given":"Yang","family":"Yu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuqian","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yicheng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjun","family":"Bao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caiying","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2895","published-online":{"date-parts":[[2024,10,6]]},"container-title":["African Health Sciences"],"original-title":[],"link":[{"URL":"https:\/\/www.ajol.info\/index.php\/ahs\/article\/download\/280082\/264177","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajol.info\/index.php\/ahs\/article\/download\/280082\/264177","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,15]],"date-time":"2024-10-15T12:54:17Z","timestamp":1728996857000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajol.info\/index.php\/ahs\/article\/view\/280082"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,6]]},"references-count":0,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2024,10,6]]}},"URL":"https:\/\/doi.org\/10.4314\/ahs.v24i3.49","relation":{},"ISSN":["1729-0503","1680-6905"],"issn-type":[{"value":"1729-0503","type":"electronic"},{"value":"1680-6905","type":"print"}],"subject":[],"published":{"date-parts":[[2024,10,6]]}}}