{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T14:10:53Z","timestamp":1762524653306,"version":"build-2065373602"},"reference-count":0,"publisher":"African Journals Online (AJOL)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Afr H. Sci."],"abstract":"<jats:p>Background: In Nigeria, HIV\/AIDS contributes to leading causes of morbidity and mortality and children living with HIV on HAART tend to live longer therefore, they are more likely to develop kidney diseases.Objective: This study aimed to evaluate the prevalence of kidney diseases in HIV-infected children and identify potential risk factors with a specific focus on antiretroviral regimens.Methods: A cross-sectional study conducted in a cohort of 121 consecutive children with HIV\/AIDS on HAART. Serum creatinine level was determined and the estimated GFR was calculated using modified Schwartz formula. Kidney disease was defined as eGFR &lt;90 mL\/min\/1.73 m2 and or dipstick proteinuria \u22651+.Results: This study included 65 (53.7%) females and 56 (46.3%) males with mean age of 10.8 \u00b1 4.3 years. The children were all on antiretroviral medication. Proteinuria was observed in 7 (5.8%) of the participants, 6 (5.0%) had mild reduction of eGFR, and 1 (0.8%) each had moderately and severely reduced eGFR. A statistically significant association was observed between renal disease and high viral load, as well as the use of an abacavir or tenofovir-based regimen.Conclusion: These findings emphasize the importance of regular kidney function monitoring and tailored antiretroviral therapy selection in the management of HIV-infected children.\r\nKeywords: HIV; kidney disease; HAART; Nigeria.<\/jats:p>","DOI":"10.4314\/ahs.v25i1.11","type":"journal-article","created":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T11:43:38Z","timestamp":1753875818000},"source":"Crossref","is-referenced-by-count":0,"title":["Kidney Disease in HIV Infected Children on HAART in Nigeria"],"prefix":"10.4314","volume":"25","author":[{"given":"Marcia","family":"M Ihekaike","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maryam","family":"Shehu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ikechukwu","family":"O Mbah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patience","family":"U Kanhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hassan","family":"Shehu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"O Isichei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2895","published-online":{"date-parts":[[2025,5,9]]},"container-title":["African Health Sciences"],"original-title":[],"link":[{"URL":"https:\/\/www.ajol.info\/index.php\/ahs\/article\/download\/294976\/277568","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajol.info\/index.php\/ahs\/article\/download\/294976\/277568","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T14:06:31Z","timestamp":1762524391000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajol.info\/index.php\/ahs\/article\/view\/294976"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,9]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,5,9]]}},"URL":"https:\/\/doi.org\/10.4314\/ahs.v25i1.11","relation":{},"ISSN":["1729-0503","1680-6905"],"issn-type":[{"type":"electronic","value":"1729-0503"},{"type":"print","value":"1680-6905"}],"subject":[],"published":{"date-parts":[[2025,5,9]]}}}