{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T13:06:29Z","timestamp":1792069589471,"version":"4.4.0"},"reference-count":0,"publisher":"African Journals Online (AJOL)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Afr H. Sci."],"abstract":"<jats:p>Background: The present study focused on evaluating serum cytokines in SCD cases and understanding these mediators' interplay with immune cells and their impact on disease severity score(DSscore).Methods: The study population of eighty-eight participants comprised twenty-one SCD cases with DSscore&gt;5, thirty-seven SCD cases with DSscore\u22645, and thirty control group. Blood samples were analyzed for T cell markers by flowcytometry and serum IL10, TNF\u03b1, IFN\u03b3, and glutathione.Results: Serum IFN\u03b3 and IL10 levels were significantly higher in cases than control(p&lt;0.05). The median(IQR) TNF\u03b1, 100.51(66.8) was higher in cases DSscore&gt;5 than those with DSscore\u22645(p=0.04). Both cases showed a significant rise in IFN\u03b3 compared to the control group(p&lt;0.05). Similarly, median(IQR) IL10, 7.9(13.3) was elevated in cases DSscore&gt;5(p=0.001) than control group. IL10 recorded a significant linear relationship with Tc-exhausted (CD8+CD279+) cells(r= 0.327,p=0.012) and Th-exhausted (CD4+CD279+) cells(r=0.265,p=0.045). A linear association(r=0.292,p=0.026) was observed between IFN\u03b3 and Tc Naive\/Effector cell ratio (CD8+NECR). Similarly, TNF\u03b1 was positively associated with the total T cell Naive\/Effector cell ratio (TNECR) (r=0.307,p=0.019). Serum glutathione levels correlatedh exhausted (CD4+CD279+) cell (r=0.393,p=0.002) and IL10 (r=0.589,p&lt;0.001). Conclusion: Cytokine profiling in SCD patients might provide insight into the underlying clinical course and vulnerability toward crisis events.\r\nKeywords: TNF\u03b1; IFN\u03b3; IL10.<\/jats:p>","DOI":"10.4314\/ahs.v25i1.36","type":"journal-article","created":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T11:43:38Z","timestamp":1753875818000},"source":"Crossref","is-referenced-by-count":2,"title":["Cytokine and immune cell interaction in immune-inflammatory response during crisis event in sickle cell disease"],"prefix":"10.4314","volume":"25","author":[{"given":"Suprava","family":"Patel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saurav","family":"Nayak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diksha","family":"Chandrakar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Preetam","family":"N Wasnik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tushar","family":"B Jagzape","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eli","family":"Mohapatra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachita","family":"Nanda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seema","family":"Shah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2895","published-online":{"date-parts":[[2025,5,9]]},"container-title":["African Health Sciences"],"original-title":[],"link":[{"URL":"https:\/\/www.ajol.info\/index.php\/ahs\/article\/download\/295261\/277810","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajol.info\/index.php\/ahs\/article\/download\/295261\/277810","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T14:06:25Z","timestamp":1762524385000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajol.info\/index.php\/ahs\/article\/view\/295261"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,9]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,5,9]]}},"URL":"https:\/\/doi.org\/10.4314\/ahs.v25i1.36","relation":{},"ISSN":["1729-0503","1680-6905"],"issn-type":[{"value":"1729-0503","type":"electronic"},{"value":"1680-6905","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5,9]]}}}