{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T00:38:12Z","timestamp":1793234292682,"version":"4.5.0"},"reference-count":0,"publisher":"African Journals Online (AJOL)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Afr H. Sci."],"abstract":"<jats:p>Background: Antibiotic resistance continues to be a threat to public health worldwide, with its associated increased healthcare costs and loss of human lives. Despite the increasing reports of multi-drug resistant (MDR) Klebsiella pneumoniae (K. pneumoniae), its prevalence and resistance patterns remain under-reported in several developing countries, including Ghana.\r\nObjectives: This study hence sought to investigate the prevalence and resistance patterns of K. pneumoniae isolates from five selected hospitals in the Ashanti region of Ghana.\r\nMethods: K. pneumoniae isolates were identified using biochemical tests, API 20 E and Matrix Assisted Laser Desorption Ionisation-Time of Flight Mass Spectrometry (MALDI-TOF MS). AST and ESBL production were determined phenotypically and via PCRResults: Twenty (20) K. pneumoniae isolates were confirmed from the samples. The isolates were resistant to ampicillin (100%), ciprofloxacin (76.67%), co-trimoxazole (75%), chloramphenicol (63.33%) and cephalosporins (76.67 to 55%). Eighteen of the K. pneumoniae isolates (90%) were multi-drug resistant (MDR) while 60% of the isolates (n=12) produced Extended Spectrum Beta-Lactamases (ESBL) with blaCTX-M, blaSHV and blaTEM \u03b2-lactamase resistant encoding genes confirmed in 83, 75 and 33% of the isolates respectively.Conclusion: There is low prevalence but high multidrug resistance and high production of ESBL among K. pneumoniae isolates from the selected hospitals.\r\nKeywords: ESBLs; K. pneumoniae; antibiotic resistance; Ghana.<\/jats:p>","DOI":"10.4314\/ahs.v25i2.4","type":"journal-article","created":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T09:13:21Z","timestamp":1756804401000},"page":"20-29","source":"Crossref","is-referenced-by-count":1,"title":["Low prevalence but high resistance of Extended Spectrum Beta-lactamase producing Klebsiella pneumoniae isolated from Hospitals in the Ashanti Region of Ghana"],"prefix":"10.4314","volume":"25","author":[{"given":"Elizabeth","family":"Akua Baidoo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivian","family":"Etsiapa Boamah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayford","family":"Odoi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaw","family":"Duah Boakye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Agyare","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2895","published-online":{"date-parts":[[2025,7,15]]},"container-title":["African Health Sciences"],"original-title":[],"link":[{"URL":"https:\/\/www.ajol.info\/index.php\/ahs\/article\/download\/300565\/282592","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajol.info\/index.php\/ahs\/article\/download\/300565\/282592","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T13:45:09Z","timestamp":1764769509000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajol.info\/index.php\/ahs\/article\/view\/300565"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,15]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2025,7,15]]}},"URL":"https:\/\/doi.org\/10.4314\/ahs.v25i2.4","relation":{},"ISSN":["1729-0503","1680-6905"],"issn-type":[{"value":"1729-0503","type":"electronic"},{"value":"1680-6905","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7,15]]}}}