{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:45:33Z","timestamp":1787168733932,"version":"build-2736575974"},"reference-count":0,"publisher":"African Journals Online (AJOL)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Afr H. Sci."],"abstract":"<jats:p>Background: Type 2 diabetes mellitus (T2DM) is significantly influenced by the Elabela hormone, Elabela has been discovered to be a new endogenous apelin receptor (APJ) ligand.\r\nObjective: To detect the potential changes of Elabela-21 and Elabela-11 levels in recently developed T2DM.\r\nMaterials and Methods: A recent cross-sectional study with 180 participants was conducted. The participants were divided into three groups based on WHO classifications: T2DM patients, prediabetic cases, and healthy controls. Five milliliters of blood samples were collected in the morning during 9-12 hours of fasting. Tests were carried out for each patient and control involving glucose and lipid profile using the enzymatic methods by a biochemical auto-analyzer, glycated hemoglobin using the ion exchange high-performance liquid chromatography (HPLC), Elabela-21, and Elabela-11 using an ELISA technique.\r\nResults: Serum Elabela-21 level in T2DM patients was (803.2067 \u00b1 11.47459 pg\/mL), and in prediabetic cases, it was (641.2417 \u00b1 3.216256 pg\/mL), which was higher than the value of the healthy controls (542.6983 \u00b1 3.59739 pg\/mL), and the differences were statistically significant (P &lt; 0.001). Also, serum Elabela-11 level was significantly higher in people with T2DM and prediabetic cases (502.6683 \u00b1 11.51197 and 339.25 \u00b1 3.452898 pg\/mL, P &lt; 0.001), respectively, compared to the healthy controls (140.83 \u00b1 3.603656 pg\/mL). These differences were statistically significant (P &lt; 0.001).\r\nConclusion: Elabela-21 and Elabela-11 levels in the blood gradually increased from prediabetes to recently developed T2DM. They were positively correlated with body mass index, glycemic, and lipid profile and negatively associated with HDL.\r\nKeywords: Lipid profile; Prediabetes; Elabela; Glycated hemoglobin; Glucose.<\/jats:p>","DOI":"10.4314\/ahs.v25i3.18","type":"journal-article","created":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T14:11:16Z","timestamp":1764771076000},"page":"136-144","source":"Crossref","is-referenced-by-count":2,"title":["Circulating Elabela-21 and Elabela-11 levels as predictive biomarkers in individuals with recently developed type 2 diabetes"],"prefix":"10.4314","volume":"25","author":[{"given":"Abdullah","family":"Abbas Hamzah Al-Rubaye","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walaa","family":"Esmail Jasim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"A Mohsin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2895","published-online":{"date-parts":[[2025,9,30]]},"container-title":["African Health Sciences"],"original-title":[],"link":[{"URL":"https:\/\/www.ajol.info\/index.php\/ahs\/article\/download\/307209\/288834","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajol.info\/index.php\/ahs\/article\/download\/307209\/288834","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T14:11:17Z","timestamp":1764771077000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajol.info\/index.php\/ahs\/article\/view\/307209"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,30]]},"references-count":0,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2025,9,30]]}},"URL":"https:\/\/doi.org\/10.4314\/ahs.v25i3.18","relation":{},"ISSN":["1729-0503","1680-6905"],"issn-type":[{"value":"1729-0503","type":"electronic"},{"value":"1680-6905","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9,30]]}}}