{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T19:03:45Z","timestamp":1788030225801,"version":"build-2784847793"},"reference-count":0,"publisher":"African Journals Online (AJOL)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Afr H. Sci."],"abstract":"<jats:p>Background: Systemic inflammatory response (SIR) occurs in normal pregnancy and is exacerbated in pre-eclampsia (PE). Most markers of SIR are expensive to measure, require trained personnel, and thus are limited for routine application in resource-limited settings. Thus, we aim to determine the clinical utility of hematologic markers of systemic inflammatory response in Preeclampsia in a resource limited setting.\r\nMethods: A cross-sectional comparative study was conducted in Enugu from April to October 2021. Forty-five women with pre-eclampsia (PE) and 45 matched normotensive (NT) pregnant women were recruited. Hematological markers of systemic inflammatory response (red cell distribution width (RDW), neutrophil-lymphocyte ratio (NLR), platelet lymphocyte ratio (PLR), monocyte lymphocyte ratio (MLR), and platelet indices) were measured using the automated Mythic 22 Orphee hematology analyzer. Statistical analysis was by student T-test, receiver operating characteristics (ROC) curve, and Pearson correlation test. A P value of &lt; 0.05 was considered significant.\r\nResults: The age difference between the groups was not significant (P = 0.76). Pregnant women with preeclampsia had significantly higher RDWS (P=0.02) and NLR (P &lt;0.001) but a significantly lower PLR (P =0.04). The NLR had the largest area under the ROC curve (AUC 0.82, 95% CI (0.74-0.906, P &lt;0.001), cut-off &gt;2.56, sensitivity 71.1%; specificity 22.2%) followed by MLR (AUC 0.68, 95% CI (0.58-0.80, P =0.002) cut-off &gt;0.18, sensitivity 64.4%; specificity: 28.9 %;)\r\nConclusion: The NLR and MLR were good and affordable biomarkers of Systemic Inflammatory response (SIR) in Preeclampsia, thus possible alternative in resource-limited settings.\r\nKeywords: Preeclampsia; hematology markers; systemic inflammatory response; pregnancy; resource limited settings.<\/jats:p>","DOI":"10.4314\/ahs.v25i3.8","type":"journal-article","created":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T14:11:16Z","timestamp":1764771076000},"page":"51-61","source":"Crossref","is-referenced-by-count":2,"title":["Assessment of some hematologic markers of Systemic Inflammatory Response (SIR) as eliable bio\u00acmarkers in detecting preeclampsia; a comparative cross-sectional study in Enugu, Nigeria"],"prefix":"10.4314","volume":"25","author":[{"given":"Theresa","family":"Ukamaka Nwagha","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Chioma Okoye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Tochukwu Enebe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Obiora Izuka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kingsley","family":"Emeka Ekwuazi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiamaka","family":"Queenet Onyebuchukwu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Nnamdi Obi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uchenna","family":"Ifeanyi Nwagha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2895","published-online":{"date-parts":[[2025,9,30]]},"container-title":["African Health Sciences"],"original-title":[],"link":[{"URL":"https:\/\/www.ajol.info\/index.php\/ahs\/article\/download\/307122\/288751","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajol.info\/index.php\/ahs\/article\/download\/307122\/288751","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T14:11:20Z","timestamp":1764771080000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajol.info\/index.php\/ahs\/article\/view\/307122"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,30]]},"references-count":0,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2025,9,30]]}},"URL":"https:\/\/doi.org\/10.4314\/ahs.v25i3.8","relation":{},"ISSN":["1729-0503","1680-6905"],"issn-type":[{"value":"1729-0503","type":"electronic"},{"value":"1680-6905","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9,30]]}}}