{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T08:04:13Z","timestamp":1784793853634,"version":"3.55.0"},"reference-count":0,"publisher":"African Journals Online (AJOL)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Afr H. Sci."],"abstract":"<jats:p>Background: Hypocholesterolaemia in pulmonary tuberculosis(TB) patients is disregarded but is a predictor of poor survival.\r\nObjectives: To determine serum lipid profile differences at diagnosis and various times of medication based on sex, HIV(human immune virus) and wasting status and factors associated with hypocholesterolaemia.\r\nMethods: A repeated cross-sectional study was conducted to assess triglyceride(TG), total cholesterol (TC), high-density lipoprotein(HDL) and low-density lipoprotein(LDL) among 414 participants.\r\nResults: Majority of the participants were males(239\/414)(58%), with a median age of 28years. TB patients showed significantly lower lipid profile at diagnosis regardless of HIV-status and sex. Presence of anaemia among HIV-seropositive participants with TB, prevalence ratio(PR):2.6, 95%confidence interval(CI):1.0-7.1, p&lt;0.05) and HIV-seronegative participants with TB(PR:2.5, 95%CI:1.1-5.5, p&lt;0.05), moderate\/severe TB(PR:2.5,95%CI:1.1-5.5, p&lt;0.05) and CD4 cells&gt;200(PR:0.3 95%CI:0.1-0.8, p&lt;0.05) among HIV-seropositive participants with TB were associated with HDL-hypocholesterolaemia. Male sex, moderate\/severe TB, body wasting, dyspnoea and chest pain were independently associated with TC-hypocholesterolaemia. Regardless of sex and wasting status, the pattern of cholesterol recovery was similar at varying times.\r\nConclusion: We envisage that hypocholesterolemia is a marker of clinical TB-disease severity and its recovery indicates treatment response.\r\nKeywords: Tuberculosis; Wasting; Hypocholesterolemia.<\/jats:p>","DOI":"10.4314\/ahs.v26i2.2","type":"journal-article","created":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T07:28:33Z","timestamp":1784791713000},"page":"1-11","source":"Crossref","is-referenced-by-count":0,"title":["Clinical severity of pulmonary Tuberculosis (TB) is associated with Hypocholesterolemia among adult patients in Uganda"],"prefix":"10.4314","volume":"26","author":[{"given":"Edirisa","family":"Kibuuka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Mukisa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ezekiel","family":"Mupere","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2895","published-online":{"date-parts":[[2026]]},"container-title":["African Health Sciences"],"original-title":[],"link":[{"URL":"https:\/\/www.ajol.info\/index.php\/ahs\/article\/download\/327786\/308283","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajol.info\/index.php\/ahs\/article\/download\/327786\/308283","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T07:28:40Z","timestamp":1784791720000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajol.info\/index.php\/ahs\/article\/view\/327786"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.4314\/ahs.v26i2.2","relation":{},"ISSN":["1729-0503","1680-6905"],"issn-type":[{"value":"1729-0503","type":"electronic"},{"value":"1680-6905","type":"print"}],"subject":[],"published":{"date-parts":[[2026]]}}}