{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T08:04:14Z","timestamp":1784793854826,"version":"3.55.0"},"reference-count":0,"publisher":"African Journals Online (AJOL)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Afr H. Sci."],"abstract":"<jats:p>Background: The prevalence of first-line ART failure in Bulawayo City, Zimbabwe's second-largest city for the year 2016 was 6.6% higher than the national average of 3.3%. We assessed the association between non-adherence and first-line ART failure persons on ART in Bulawayo City.\r\nMethods: A 1:1 case-control study was done to measure the association between adherence and other risk factors for treatment failure among 169 cases and 169 controls. The Morisky Medication adherence 8-item scale was used to assess self-reported adherence, and non-adherence was defined as having a self-reported score of 1 to 8. Epi info 7 was used for univariate, bivariate, and multivariate analysis.\r\nResults: Persons who were non-adherent to ART were 5 times more likely to experience treatment failure than those who adhered association between non-adherence and treatment failure (OR=5.1, 95% CI 2.9-8.9). The study established that 58% of the cases had good knowledge of adherence to ART compared to 85% of the controls. Stopping medication when feeling worse (AOR=3.5, 95% CI 1.8-7.0) was the most significant independent risk factor for treatment failure.\r\nConclusions: The study found a strong association between non-adherence and treatment failure. Routine monitoring at every clinic visit of clients on ART should be done to monitor the client's adherence to medication.\r\nKeywords: Non-adherence; First line Antiretroviral Therapy Failure; Bulawayo City.<\/jats:p>","DOI":"10.4314\/ahs.v26i2.4","type":"journal-article","created":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T07:28:33Z","timestamp":1784791713000},"page":"23-30","source":"Crossref","is-referenced-by-count":0,"title":["Non-Adherence and First Line Antiretroviral Therapy failure among people living  with HIV on Antiretroviral Therapy in Bulawayo city, 2016"],"prefix":"10.4314","volume":"26","author":[{"given":"Martin","family":"Tatenda Dzimbanhete","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerald","family":"Shambira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mufuta","family":"Tshimanga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Notion","family":"Tafara Gombe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zanele","family":"Hwalima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiedza","family":"Sibanda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cleophas","family":"Chimbetete","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2895","published-online":{"date-parts":[[2026]]},"container-title":["African Health Sciences"],"original-title":[],"link":[{"URL":"https:\/\/www.ajol.info\/index.php\/ahs\/article\/download\/327803\/308311","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajol.info\/index.php\/ahs\/article\/download\/327803\/308311","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T07:28:40Z","timestamp":1784791720000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajol.info\/index.php\/ahs\/article\/view\/327803"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.4314\/ahs.v26i2.4","relation":{},"ISSN":["1729-0503","1680-6905"],"issn-type":[{"value":"1729-0503","type":"electronic"},{"value":"1680-6905","type":"print"}],"subject":[],"published":{"date-parts":[[2026]]}}}