{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T13:13:41Z","timestamp":1771334021021,"version":"3.50.1"},"reference-count":0,"publisher":"African Journals Online (AJOL)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ethiop J Health Sci"],"abstract":"<jats:p>BACKGROUND: Neural tube defects (NTDs) occur as a result of incomplete closure of the neural tube by the embryonic age of 26 to 28 days. Addressing factors associated with NTDs would help to identify and prioritize high-risk women, which in turn guides the preventive strategy. The study aimed to identify factors associated with NTDs among women who gave birth or had a second-trimester abortion at Adama Hospital Medical College, from January 1st to December 31st, 2019.\r\nMETHODS:\u00a0Hospital based unmatched case-control study was conducted on 344 women. Data were analyzed with SPSS 20. Descriptive statistics were computed. Binary logistic regression analysis was performed to determine factors associations with NTDs.\r\nRESULTS:\u00a0The odds of having a fetus with NTDs were 2.19 times higher among women who are not in a marital relationship (AOR = 2.19; 95% CI: 1.13, 4.25). Women with a previous history of Abortion or stillbirth had 3 fold increased risk of having a fetus with NTDs (AOR = 3.05; 95% CI: 1.58, 5.88). Inadequate housing condition nearly doubles the odds of having a fetus with NTDs (AOR = 1.91; 95% CI: 1.20, 3.04). Folic acid or multivitamin supplementation early in pregnancy reduced the odds of having a fetus with NTDs by 43% (AOR = 0.57; 95% CI: 0.35, 0.91)\u00a0\u00a0\r\nCONCLUSION:\u00a0Being not in a marital relationship, previous history of abortion or stillbirth, and living in inadequate housing conditions were risk factors for NTDs, while multivitamins or folic acid supplementation was a protective factor.<\/jats:p>","DOI":"10.4314\/ejhs.v33i4.9","type":"journal-article","created":{"date-parts":[[2024,7,24]],"date-time":"2024-07-24T09:31:39Z","timestamp":1721813499000},"source":"Crossref","is-referenced-by-count":1,"title":["Factors Associated with Neural Tube Defects among Women Who Gave Birth at Adama Hospital Medical College, Adama, Ethiopia: A Case Control Study"],"prefix":"10.4314","volume":"33","author":[{"family":"Dereje Tegene","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Ephrem Mannekulih","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2895","published-online":{"date-parts":[[2023,8,17]]},"container-title":["Ethiopian Journal of Health Sciences"],"original-title":[],"link":[{"URL":"https:\/\/www.ajol.info\/index.php\/ejhs\/article\/download\/253096\/239149","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajol.info\/index.php\/ejhs\/article\/download\/253096\/239149","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,24]],"date-time":"2024-07-24T09:32:01Z","timestamp":1721813521000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajol.info\/index.php\/ejhs\/article\/view\/253096"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,17]]},"references-count":0,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2023,10,10]]}},"URL":"https:\/\/doi.org\/10.4314\/ejhs.v33i4.9","relation":{},"ISSN":["2413-7170","1029-1857"],"issn-type":[{"value":"2413-7170","type":"electronic"},{"value":"1029-1857","type":"print"}],"subject":[],"published":{"date-parts":[[2023,8,17]]}}}