{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T19:43:46Z","timestamp":1790451826550,"version":"4.1.0"},"reference-count":0,"publisher":"African Journals Online (AJOL)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ethiop J Health Sci"],"abstract":"<jats:p>Background: Vulvovaginal candidiasis is one of the most common vaginal infections worldwide. We conducted this systematic review\u00a0 and meta-analysis to determine the effect of probiotics in the treatment of vulvovaginal candidiasis.\r\nMethods: A comprehensive search\u00a0 of databases including PubMed, Scopus, Cochrane, Scientific Information Database (SID), IranMedex, and Google Scholar search engine\u00a0 was performed. The search was conducted from inception to 1 October 2022, to identify published English or Persian language randomized control trials (RCTs) of women with vulvovaginal candidiasis who received probiotics as medical treatment. The quality of the\u00a0 included studies was assessed using the Oxford Center for Evidence Based Medicine checklist. All statistical analyses were performed\u00a0 using Comprehensive Meta-analysis (CMA) version 2.\r\nResults: Six RCTs were included in this review. The results showed that treatment\u00a0 with probiotic was not different from placebo regarding the rate of positive culture (OR: 1.12; 95% CI: 0.390 to 3.26, P=0.825); treatment\u00a0 with probiotic was more effective compared to placebo regarding the rate of recurrence. (OR: 0.14; P= 0.01; 95 % CI: 0.028\u20130.7).\u00a0\u00a0\r\nConclusion: Probiotics have a beneficial effect in the treatment of women with vulvovaginal candidiasis. Our results provide evidence for\u00a0 an alternative treatment modality for vaginal candidiasis using probiotics.\u00a0<\/jats:p>","DOI":"10.4314\/ejhs.v33i5.18","type":"journal-article","created":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T14:58:53Z","timestamp":1695913133000},"page":"881-890","source":"Crossref","is-referenced-by-count":13,"title":["The Role of Probiotics in the Treatment of Vulvovaginal Candidiasis: A Systematic Review and Meta-Analysis"],"prefix":"10.4314","volume":"33","author":[{"given":"Tahere","family":"Zahedifard","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Talat","family":"Khadivzadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marzieh","family":"Rakhshkhorshid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2895","published-online":{"date-parts":[[2023,9,21]]},"container-title":["Ethiopian Journal of Health Sciences"],"original-title":[],"link":[{"URL":"https:\/\/www.ajol.info\/index.php\/ejhs\/article\/download\/255818\/241682","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajol.info\/index.php\/ejhs\/article\/download\/255818\/241682","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T14:59:27Z","timestamp":1695913167000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajol.info\/index.php\/ejhs\/article\/view\/255818"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,21]]},"references-count":0,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2023,9,21]]}},"URL":"https:\/\/doi.org\/10.4314\/ejhs.v33i5.18","relation":{},"ISSN":["2413-7170","1029-1857"],"issn-type":[{"value":"2413-7170","type":"electronic"},{"value":"1029-1857","type":"print"}],"subject":[],"published":{"date-parts":[[2023,9,21]]}}}