{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:59:27Z","timestamp":1760144367222,"version":"build-2065373602"},"reference-count":0,"publisher":"African Journals Online (AJOL)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ethiop J Health Sci"],"abstract":"<jats:p>Alport syndrome (AS) is a rare, inherited disorder affecting the basement membranes of the glomerulus, cochlea, and lens. It presents with visual and hearing deficits, as well as kidney disease, which can progress to end-stage renal failure and death. A 26-year-old male presented with a three-week history of body swelling, foamy urine, worsening hematuria, and hearing and visual impairments of 17- and 10-years\u2019 duration, respectively. Three of his siblings (two males and one female) had similar symptoms. Molecular genetic screening, involving children from the two wives, identified a pathogenic mutation in the COL4A5 gene, confirming X-linked AS in the patient and his three maternal siblings. The patient underwent maintenance hemodialysis (HD), followed by two failed living-related kidney transplants, and died in his sleep a year after the second transplant, hours after a routine dialysis session.\r\nMultiple deaths from AS within a family can contribute to grand multiparity, particularly in low-income settings.<\/jats:p>","DOI":"10.4314\/ejhs.v35i1.10","type":"journal-article","created":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:26:46Z","timestamp":1760106406000},"source":"Crossref","is-referenced-by-count":0,"title":["Alport Syndrome May contribute to Grand Multiparity in a Typical Low Income Setting"],"prefix":"10.4314","volume":"35","author":[{"family":"Victoria I Ogala-Akogwu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Peter K Uduagbamen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Emmauuel A Anteyi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Habib AGaladanci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2895","published-online":{"date-parts":[[2025,2,6]]},"container-title":["Ethiopian Journal of Health Sciences"],"original-title":[],"link":[{"URL":"https:\/\/www.ajol.info\/index.php\/ejhs\/article\/download\/288379\/271658","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajol.info\/index.php\/ejhs\/article\/download\/288379\/271658","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:26:54Z","timestamp":1760106414000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajol.info\/index.php\/ejhs\/article\/view\/288379"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,6]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,2,6]]}},"URL":"https:\/\/doi.org\/10.4314\/ejhs.v35i1.10","relation":{},"ISSN":["2413-7170","1029-1857"],"issn-type":[{"value":"2413-7170","type":"electronic"},{"value":"1029-1857","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2,6]]}}}