{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T17:10:27Z","timestamp":1770225027924,"version":"3.49.0"},"reference-count":0,"publisher":"African Journals Online (AJOL)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["gmj"],"abstract":"<jats:p>Objective: This study determined the occurrence and distribution of Extended Spectrum \u03b2-Lactamase (ESBL) genotypes of E. coli isolates in Ho Teaching Hospital, Ghana.Design: A cross-sectional study.Setting: A single centre study was conducted at Ho Teaching Hospital of Ghana.Participants: Patients who visited Ho Teaching Hospital Laboratory with the request for culture and susceptibility testing.Main outcome measure: Escherichia coli were isolated, and Extended-Spectrum \u03b2-Lactamase genes were detected.Results: Of the 135 isolates, 56(41.5%,95% CI: 33.1% \u2013 50.3%) were ESBL producers. More males, 14(58.3%), produced ESBL than females, 42(37.8%). The ESBL prevalence was highest among the elderly who were 80 years and above 3(100.0%), with the least prevalence among patients within 50-59 years and 0-9 years age bracket, representing 4(25.0%) and 3(27.3%), respectively. The total prevalence of ESBL was marginally higher among out-patients (41.8% 95% CI: 31.9% - 52.2%) compared to in-patients [40.5% 95% CI: 24.8% - 57.9]. BlaTEM-1 was the predominant ESBL genotype obtained from 83.9% (47\/56) of the confirmed ESBL producing isolates, with the least being TOHO-1 4(7.1%). The co-existence of 2 different ESBL genes occurred in 19(33.9%) of the isolates. The single and quadruple carriage were 16(28.6%) and 3(5.4%), respectively. The highest co-existence of the ESBL genotypes was recorded for blaTEM-1 and blaCTXM-1 15(26.8%), followed by blaTEM-1, blaCTXM-1 and blaSHV-73 [12(21.4%)].Conclusion: The high prevalence of ESBL-producing E. coli isolates with multiple resistant gene carriage is a threat to healthcare in the study area.<\/jats:p>","DOI":"10.4314\/gmj.v55i4.11","type":"journal-article","created":{"date-parts":[[2022,1,26]],"date-time":"2022-01-26T13:08:00Z","timestamp":1643202480000},"page":"298-307","source":"Crossref","is-referenced-by-count":18,"title":["Occurrence and distribution of extended-spectrum \u03b2-lactamase in clinical Escherichia coli isolates at Ho Teaching Hospital in Ghana."],"prefix":"10.4314","volume":"55","author":[{"given":"John","family":"G. Deku","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kwabena","family":"O. Duedu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emmanuel","family":"Ativi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Godsway","family":"E. Kpene","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"K. Feglo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2895","published-online":{"date-parts":[[2021,12,1]]},"container-title":["Ghana Medical Journal"],"original-title":[],"link":[{"URL":"https:\/\/www.ajol.info\/index.php\/gmj\/article\/download\/220069\/207662","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajol.info\/index.php\/gmj\/article\/download\/220069\/207662","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,26]],"date-time":"2022-01-26T13:08:22Z","timestamp":1643202502000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajol.info\/index.php\/gmj\/article\/view\/220069"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,1]]},"references-count":0,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2022,1,15]]}},"URL":"https:\/\/doi.org\/10.4314\/gmj.v55i4.11","relation":{},"ISSN":["0016-9560"],"issn-type":[{"value":"0016-9560","type":"print"}],"subject":[],"published":{"date-parts":[[2021,12,1]]}}}