{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T05:00:12Z","timestamp":1790744412371,"version":"4.1.0"},"reference-count":0,"publisher":"African Journals Online (AJOL)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["gmj"],"abstract":"<jats:p>Objective: To determine if the number of vaso-occlusive events in SCD relates to plasma concentration of fucosyl-transferase 7 (FUT7), which catalyses the synthesis of selectin ligands.Design: A prospective, analytical study.Setting: Haematology and Chemical Pathology Departments of tertiary healthcare centersParticipants: Steady state HbSS individuals aged 13-45 years, 20 had 3 or more vaso-occlusive crises that required hospital admission in the previous year (with or without complications of SCD); 17 other HbSS persons had 0-1 vaso-occlusive crisis that required hospital admission in the previous year and no disease complications.Intervention: Steady-state plasma concentrations of FUT7 measured by ELISA were compared between SCD patients who had one vaso-occlusive crisis requiring hospital treatment in the previous year but no disease complications and those who had &gt;3 crises with or without complications.Main Outcome Measures: Plasma level of FUT7and the number of vaso-occlusive events in each HbSS patientResults: Mean + standard deviation plasma concentration of FUT7 was 8.6 + 2.7 ng\/ml in patients with &gt;3 vaso-occlusive crises in the previous year and 7.3 + 1.7 ng\/ml in those with 0-1 crisis and no complications; independent sample t-test, p &gt; 0.05, not significantly different.Conclusion: Plasma concentration of fucosyltransferase7 is not associated with the number of vaso-occlusive events in sickle cell disease.<\/jats:p>","DOI":"10.4314\/gmj.v57i3.6","type":"journal-article","created":{"date-parts":[[2024,1,8]],"date-time":"2024-01-08T10:30:44Z","timestamp":1704709844000},"page":"198-203","source":"Crossref","is-referenced-by-count":3,"title":["Plasma concentration of fucosyltransferase 7 is not associated with the number of clinically overt vaso-occlusive events in sickle cell disease"],"prefix":"10.4314","volume":"57","author":[{"given":"Iheanyi","family":"E. Okpala","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Onyinye","family":"E. Eze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chinedu","family":"A. Ezekekwu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ifeyinwa","family":"D. Nnakenyi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gladys","family":"U. Ilechukwu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chinedu","family":"O. Akpa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"I. Nwani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Collins","family":"J. Maduka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ikechukwu","family":"O. Anigbogu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ebele","family":"D. Muoghalu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ngozi","family":"I. Ugwu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ifeoma","family":"C. Ajuba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"C. Aneke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"C. Okoye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"C. Nonyelu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Augustine","family":"N. Duru","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2895","published-online":{"date-parts":[[2023,9,17]]},"container-title":["Ghana Medical Journal"],"original-title":[],"link":[{"URL":"https:\/\/www.ajol.info\/index.php\/gmj\/article\/download\/255183\/241127","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajol.info\/index.php\/gmj\/article\/download\/255183\/241127","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,8]],"date-time":"2024-01-08T10:31:18Z","timestamp":1704709878000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajol.info\/index.php\/gmj\/article\/view\/255183"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,17]]},"references-count":0,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2023,9,17]]}},"URL":"https:\/\/doi.org\/10.4314\/gmj.v57i3.6","relation":{},"ISSN":["0016-9560"],"issn-type":[{"value":"0016-9560","type":"print"}],"subject":[],"published":{"date-parts":[[2023,9,17]]}}}