{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T23:26:10Z","timestamp":1775863570335,"version":"3.50.1"},"reference-count":0,"publisher":"African Journals Online (AJOL)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["gmj"],"abstract":"<jats:p>Objective: To assess the performance of the Sex Hormone-Binding Globulin (SHBG) assay as a diagnostic indicator of Gestational Diabetes Mellitus (GDM) in the study population.Design: Analytical cross-sectional studySetting: Hospital-based, Benue State University Teaching Hospital (BSUTH), Makurdi, Nigeria.Participants: Women with singleton pregnancies at 24 to 28 weeks gestational age attending Antenatal care at BSUTH, Makurdi.Intervention: Serum SHBG levels were assayed by ELISA during a diagnostic 75-gram Oral Glucose Tolerance Test (OGTT) for assessment of GDM in the cohort of consecutively selected participants who met the inclusion criteria.Main Outcome Measures: Serum levels of SHBG and presence of GDM in the participants.Result: Serum SHBG was significantly negatively correlated (rpb = - 0.534, p-value &lt; 0.001) with the presence of GDM. It had an area under the ROC curve of 0.897 (95% Confidence Interval = 0.858\u20130.935; p-value &lt; 0.001). A cut-off value of 452.0 nmol\/L indicative of GDM had a diagnostic odds ratio of 21.4 in the study population.Conclusion: SHBG is a valuable diagnostic indicator for GDM in the study population.<\/jats:p>","DOI":"10.4314\/gmj.v58i1.8","type":"journal-article","created":{"date-parts":[[2024,3,28]],"date-time":"2024-03-28T06:00:44Z","timestamp":1711605644000},"page":"53-59","source":"Crossref","is-referenced-by-count":6,"title":["Sex hormone-binding globulin is a valuable diagnostic indicator of gestational diabetes mellitus"],"prefix":"10.4314","volume":"58","author":[{"given":"Basil","family":"Bruno","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Myke-Mbata","family":"K. Blessing","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mba","family":"N. Izuchukwu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gbaa","family":"T. Terry","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dogoh","family":"Faeren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2895","published-online":{"date-parts":[[2024,3,25]]},"container-title":["Ghana Medical Journal"],"original-title":[],"link":[{"URL":"https:\/\/www.ajol.info\/index.php\/gmj\/article\/download\/267454\/252348","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajol.info\/index.php\/gmj\/article\/download\/267454\/252348","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,28]],"date-time":"2024-03-28T06:02:32Z","timestamp":1711605752000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajol.info\/index.php\/gmj\/article\/view\/267454"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,25]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,3,25]]}},"URL":"https:\/\/doi.org\/10.4314\/gmj.v58i1.8","relation":{},"ISSN":["0016-9560"],"issn-type":[{"value":"0016-9560","type":"print"}],"subject":[],"published":{"date-parts":[[2024,3,25]]}}}